| # | Title | Journal | Year | Citations |
|---|
| 1 | Detection of specific sequences among DNA fragments separated by gel electrophoresis | Journal of Molecular Biology | 1975 | 35,546 |
| 2 | The assessment and analysis of handedness: The Edinburgh inventory | Neuropsychologia | 1971 | 32,207 |
| 3 | Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030 | Diabetes Care | 2004 | 12,778 |
| 4 | The Pascal Visual Object Classes (VOC) Challenge | International Journal of Computer Vision | 2010 | 12,097 |
| 5 | Bounds testing approaches to the analysis of level relationships | Journal of Applied Econometrics | 2001 | 11,119 |
| 6 | BEAST: Bayesian evolutionary analysis by sampling trees | BMC Evolutionary Biology | 2007 | 11,072 |
| 7 | Detection of Postnatal Depression | British Journal of Psychiatry | 1987 | 10,506 |
| 8 | Testing for unit roots in heterogeneous panels | Journal of Econometrics | 2003 | 9,755 |
| 9 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 10 | Q-learning | Machine Learning | 1992 | 8,093 |
| 11 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 12 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 6,753 |
| 13 | Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7 | Systematic Biology | 2018 | 6,726 |
| 14 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 15 | DNA methylation patterns and epigenetic memory | Genes and Development | 2002 | 5,932 |
| 16 | Epigenetic programming by maternal behavior | Nature Neuroscience | 2004 | 5,564 |
| 17 | Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment | Psychological Medicine | 1998 | 5,439 |
| 18 | Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals | Nature Genetics | 2003 | 5,434 |
| 19 | BEAST 2: A Software Platform for Bayesian Evolutionary Analysis | PLoS Computational Biology | 2014 | 5,301 |
| 20 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 21 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 22 | Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer | New England Journal of Medicine | 2005 | 4,601 |
| 23 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 4,468 |
| 24 | THE SEVENTH DATA RELEASE OF THE SLOAN DIGITAL SKY SURVEY | Astrophysical Journal, Supplement Series | 2009 | 4,201 |
| 25 | Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism | Nature | 1961 | 4,162 |
| 26 | The Pascal Visual Object Classes Challenge: A Retrospective | International Journal of Computer Vision | 2015 | 4,116 |
| 27 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 28 | Definition and classification of cancer cachexia: an international consensus | Lancet Oncology, The | 2011 | 4,015 |
| 29 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 30 | Cerebral organoids model human brain development and microcephaly | Nature | 2013 | 3,889 |
| 31 | The proximal origin of SARS-CoV-2 | Nature Medicine | 2020 | 3,871 |
| 32 | Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial | Lancet, The | 2005 | 3,840 |
| 33 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 34 | Simulations of the formation, evolution and clustering of galaxies and quasars | Nature | 2005 | 3,801 |
| 35 | Whatever next? Predictive brains, situated agents, and the future of cognitive science | Behavioral and Brain Sciences | 2013 | 3,782 |
| 36 | Statistical confidence for likelihood‐based paternity inference in natural populations | Molecular Ecology | 1998 | 3,771 |
| 37 | Pooled Mean Group Estimation of Dynamic Heterogeneous Panels | Journal of the American Statistical Association | 1999 | 3,720 |
| 38 | Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips | Nature Protocols | 2007 | 3,693 |
| 39 | Detection of the Baryon Acoustic Peak in the Large‐Scale Correlation Function of SDSS Luminous Red Galaxies | Astrophysical Journal | 2005 | 3,564 |
| 40 | Macrophage biology in development, homeostasis and disease | Nature | 2013 | 3,541 |
| 41 | Recovery of inter-block information when block sizes are unequal | Biometrika | 1971 | 3,289 |
| 42 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 43 | Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells | Nature Genetics | 2000 | 3,248 |
| 44 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 45 | An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias | American Journal of Respiratory and Critical Care Medicine | 2013 | 3,134 |
| 46 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 47 | Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex | Nature | 1998 | 3,102 |
| 48 | Tumor-Associated Macrophages: From Mechanisms to Therapy | Immunity | 2014 | 3,060 |
| 49 | Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 | Cell | 1998 | 3,037 |
| 50 | Broken Symmetries and the Masses of Gauge Bosons | Physical Review Letters | 1964 | 2,944 |
