| # | Title | Journal | Year | Citations |
|---|
| 1 | Prednisone plus cabazitaxel or mitoxantrone for metastatic castration-resistant prostate cancer progressing after docetaxel treatment: a randomised open-label trial | Lancet, The | 2010 | 2,857 |
| 2 | Medication Compliance and Persistence: Terminology and Definitions | Value in Health | 2008 | 1,701 |
| 3 | Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions | Nature Medicine | 2001 | 1,484 |
| 4 | Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy | Nature Genetics | 2000 | 1,275 |
| 5 | Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study | Lancet, The | 2008 | 1,258 |
| 6 | Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 | Nature Medicine | 2002 | 1,008 |
| 7 | Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma | New England Journal of Medicine | 2018 | 816 |
| 8 | Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells | Science | 2009 | 797 |
| 9 | A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells | Cell | 2012 | 762 |
| 10 | Measuring normal and pathological anxiety-like behaviour in mice: a review | Behavioural Brain Research | 2001 | 753 |
| 11 | Increasing Prevalence of Atrial Fibrillation and Flutter in the United States | American Journal of Cardiology | 2009 | 746 |
| 12 | Use of Pharmacogenetic and Clinical Factors to Predict the Therapeutic Dose of Warfarin | Clinical Pharmacology and Therapeutics | 2008 | 743 |
| 13 | Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells | Nature | 2010 | 727 |
| 14 | Identification and Biological Activity of the Active Metabolite of Clopidogrel | Thrombosis and Haemostasis | 2000 | 688 |
| 15 | CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity | International Journal of Obesity | 2004 | 515 |
| 16 | Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice | American Journal of Physiology - Regulatory Integrative and Comparative Physiology | 2003 | 493 |
| 17 | Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal | Biological Psychiatry | 2008 | 482 |
| 18 | Fourth International Workgroup on Genotoxicity testing: Results of the in vivo Comet assay workgroup | Mutation Research - Genetic Toxicology and Environmental Mutagenesis | 2007 | 452 |
| 19 | A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next? | Angewandte Chemie - International Edition | 2004 | 428 |
| 20 | Prevalence of insomnia in a survey of 12 778 adults in France | Journal of Sleep Research | 2000 | 427 |
| 21 | Peripheral benzodiazepine receptors and mitochondrial function | Neurochemistry International | 2002 | 417 |
| 22 | Insomnia and the Performance of US Workers: Results from the America Insomnia Survey | Sleep | 2011 | 417 |
| 23 | Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study | Diabetologia | 2006 | 405 |
| 24 | A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity | Regulatory Toxicology and Pharmacology | 2006 | 393 |
| 25 | Prevalence and Perceived Health Associated with Insomnia Based on DSM-IV-TR; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision; and Research Diagnostic Criteria/International Classification of Sleep Disorders, Second Edition Criteria: Results from the America Insomnia Survey | Biological Psychiatry | 2011 | 390 |
| 26 | SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats | Behavioural Pharmacology | 2002 | 387 |
| 27 | Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice | Psychopharmacology | 2000 | 379 |
| 28 | Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic | Neuroscience and Biobehavioral Reviews | 2001 | 379 |
| 29 | Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders | Trends in Pharmacological Sciences | 2003 | 374 |
| 30 | Hyponatremia in cirrhosis: Results of a patient population survey | Hepatology | 2006 | 349 |
| 31 | Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression | Journal of the American Society for Mass Spectrometry | 1996 | 338 |
| 32 | Rab GTPases at a glance | Journal of Cell Science | 2007 | 331 |
| 33 | Risk assessment as an evolved threat detection and analysis process | Neuroscience and Biobehavioral Reviews | 2011 | 329 |
| 34 | The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways | Journal of Experimental Medicine | 2002 | 325 |
| 35 | Fractalkine modulates TNF-? secretion and neurotoxicity induced by microglial activation | Journal of Experimental Medicine | 2000 | 323 |
| 36 | Society of Toxicologic Pathology Position Paper: Organ Weight Recommendations for Toxicology Studies | Toxicologic Pathology | 2007 | 310 |
| 37 | How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines? | British Journal of Pharmacology | 2011 | 306 |
| 38 | Evaluation of Organ Weights for Rodent and Non-Rodent Toxicity Studies: A Review of Regulatory Guidelines and a Survey of Current Practices | Toxicologic Pathology | 2007 | 298 |
| 39 | Improvement of Glycemic Control in Subjects With Poorly Controlled Type 2 Diabetes: Comparison of two treatment algorithms using insulin glargine | Diabetes Care | 2005 | 288 |
| 40 | Hypoxia induces the expression of the pro-apoptotic gene BNIP3 | Cell Death and Differentiation | 2001 | 282 |
| 41 | Barriers to Adult Immunization | American Journal of Medicine | 2008 | 281 |
| 42 | Structure-Based Drug Design: Docking and Scoring | Current Protein and Peptide Science | 2007 | 279 |
| 43 | Multicenter evaluation of the use of venous thromboembolism prophylaxis in acutely ill medical patients in Canada | Thrombosis Research | 2007 | 257 |
| 44 | Estimated annual numbers of US acute‐care hospital patients at risk for venous thromboembolism | American Journal of Hematology | 2007 | 257 |
| 45 | 4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1, 3-thiazol-2-amine Hydrochloride (SSR125543A), a Potent and Selective Corticotrophin-Releasing Factor1 Receptor Antagonist. II. Characterization in Rodent Models of Stress-Related Disorders | Journal of Pharmacology and Experimental Therapeutics | 2002 | 242 |
| 46 | SSR180711, a Novel Selective α7 Nicotinic Receptor Partial Agonist: (II) Efficacy in Experimental Models Predictive of Activity Against Cognitive Symptoms of Schizophrenia | Neuropsychopharmacology | 2007 | 239 |
| 47 | Proliferative and Nonproliferative Lesions of the Rat and Mouse Urinary System | Toxicologic Pathology | 2012 | 239 |
| 48 | Accelerating Next-Generation Vaccine Development for Global Disease Prevention | Science | 2013 | 236 |
| 49 | The REduction of Atherothrombosis for Continued Health (REACH) Registry: An international, prospective, observational investigation in subjects at risk for atherothrombotic events-study design | American Heart Journal | 2006 | 235 |
| 50 | The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic | European Journal of Pharmacology | 2003 | 231 |
