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Top Articles

#TitleJournalYearCitations
1Long Short-Term MemoryNeural Computation199758,553
2A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research200128,594
3Improved Survival with Ipilimumab in Patients with Metastatic MelanomaNew England Journal of Medicine201013,065
4The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR ExperimentsClinical Chemistry200912,487
5Immunity, Inflammation, and CancerCell20108,516
6Ecological responses to recent climate changeNature20027,926
7Phylogenetic identification and in situ detection of individual microbial cells without cultivationMicrobiological Reviews19957,112
8Global Biodiversity Scenarios for the Year 2100 Science20007,077
9Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelinesJournal of Extracellular Vesicles20186,961
10Relative expression software tool (REST(C)) for group-wise comparison and statistical analysis of relative expression results in real-time PCRNucleic Acids Research20026,443
11Many-body physics with ultracold gasesReviews of Modern Physics20086,386
12Open Babel: An open chemical toolboxJournal of Cheminformatics20116,039
13A Toll-like receptor recognizes bacterial DNANature20005,827
14ARB: a software environment for sequence dataNucleic Acids Research20045,816
15Phylogenetic identification and in situ detection of individual microbial cells without cultivation.Microbiological Reviews19955,008
16V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation20164,902
17THREE NATURAL ZIRCON STANDARDS FOR U-TH-PB, LU-HF, TRACE ELEMENT AND REE ANALYSESGeostandards and Geoanalytical Research19954,868
18Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
19Persistence of soil organic matter as an ecosystem propertyNature20114,243
20IL-17 and Th17 CellsAnnual Review of Immunology20094,231
21Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – Excel-based tool using pair-wise correlationsBiotechnology Letters20044,156
22Current Concepts in Mild Cognitive ImpairmentArchives of Neurology20014,117
23Trends in the Exchange Current for Hydrogen EvolutionJournal of the Electrochemical Society20054,054
24Host–microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseNature20124,038
25Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018Cell Death and Differentiation20184,036
26SCANPY: large-scale single-cell gene expression data analysisGenome Biology20183,958
27Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementiaBrain20113,913
28Multicomponent Reactions with IsocyanidesAngewandte Chemie - International Edition20003,733
29Iterative partial equalization of orbital electronegativity—a rapid access to atomic chargesTetrahedron19803,706
30N-Heterocyclic Carbenes: A New Concept in Organometallic CatalysisAngewandte Chemie - International Edition20023,581
31Skyrmion Lattice in a Chiral MagnetScience20093,560
32Raman microspectroscopy of soot and related carbonaceous materials: Spectral analysis and structural informationCarbon20053,468
33Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8Science20043,413
34Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trialLancet, The20163,077
35Trends in electrocatalysis on extended and nanoscale Pt-bimetallic alloy surfacesNature Materials20072,902
36Toward discovery science of human brain functionProceedings of the National Academy of Sciences of the United States of America20102,703
37The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years AfterSurgery20172,655
38Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics20102,634
39Science and technology roadmap for graphene, related two-dimensional crystals, and hybrid systemsNanoscale20152,452
40Shifting the limits in wheat research and breeding using a fully annotated reference genomeScience20182,424
41European phenological response to climate change matches the warming patternGlobal Change Biology20062,412
42Alternative Activation of Macrophages: An Immunologic Functional PerspectiveAnnual Review of Immunology20092,380
43FlowNet: Learning Optical Flow with Convolutional Networks20152,361
44Host microbiota constantly control maturation and function of microglia in the CNSNature Neuroscience20152,340
45Bias in random forest variable importance measures: Illustrations, sources and a solutionBMC Bioinformatics20072,328
46Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus PanelEuropean Heart Journal20172,292
47RGD modified polymers: biomaterials for stimulated cell adhesion and beyondBiomaterials20032,286
48Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in miceNature Cell Biology20142,241
49International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women: A 2010 Update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious DiseasesClinical Infectious Diseases20112,194
50A benchmark for the evaluation of RGB-D SLAM systems20122,188