# | Title | Journal | Year | Citations |
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1 | Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer | New England Journal of Medicine | 2004 | 4,721 |
2 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
3 | Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer | New England Journal of Medicine | 2009 | 3,543 |
4 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
5 | Meta-analyses involving cross-over trials: methodological issues | International Journal of Epidemiology | 2002 | 1,999 |
6 | Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial | Lancet, The | 2009 | 1,321 |
7 | Crystal Structure of the Extracellular Segment of Integrin αVβ3 | Science | 2001 | 1,202 |
8 | Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME | Archives of Toxicology | 2013 | 1,089 |
9 | Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial | Lancet Oncology, The | 2016 | 1,034 |
10 | On the use of vinylene carbonate (VC) as an additive to electrolyte solutions for Li-ion batteries | Electrochimica Acta | 2002 | 852 |
11 | Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy | Molecular Cell | 2014 | 849 |
12 | Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial | Lancet Oncology, The | 2014 | 800 |
13 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial | Lancet Oncology, The | 2013 | 740 |
14 | Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study | Annals of Oncology | 2011 | 696 |
15 | Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies | Drug Metabolism Reviews | 2007 | 673 |
16 | PRODRG, a program for generating molecular topologies and unique molecular descriptors from coordinates of small molecules | Journal of Computer-Aided Molecular Design | 1996 | 596 |
17 | Solid‐State Electrochemical Kinetics of Li‐Ion Intercalation into Li1 − x CoO2: Simultaneous Application of Electroanalytical Techniques SSCV, PITT, and EIS | Journal of the Electrochemical Society | 1999 | 595 |
18 | LIGSITE: automatic and efficient detection of potential small molecule-binding sites in proteins | Journal of Molecular Graphics and Modelling | 1997 | 589 |
19 | Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton | Nature Cell Biology | 2002 | 569 |
20 | Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study | Breast Cancer Research and Treatment | 2018 | 564 |
21 | Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer | JAMA Oncology | 2017 | 555 |
22 | RANTES Deposition by Platelets Triggers Monocyte Arrest on Inflamed and Atherosclerotic Endothelium | Circulation | 2001 | 536 |
23 | EGFR expression as a predictor of survival for first-line chemotherapy plus cetuximab in patients with advanced non-small-cell lung cancer: analysis of data from the phase 3 FLEX study | Lancet Oncology, The | 2012 | 526 |
24 | Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials | Lancet Oncology, The | 2009 | 519 |
25 | Combined Calcium and Vitamin D3 Supplementation in Elderly Women: Confirmation of Reversal of Secondary Hyperparathyroidism and Hip Fracture Risk: The Decalyos II Study | Osteoporosis International | 2002 | 506 |
26 | Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: Pooled analysis of the CRYSTAL and OPUS randomised clinical trials | European Journal of Cancer | 2012 | 506 |
27 | The Study of Surface Phenomena Related to Electrochemical Lithium Intercalation into Li[sub x]MO[sub y] Host Materials (M = Ni, Mn) | Journal of the Electrochemical Society | 2000 | 500 |
28 | Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010 | Archives of Toxicology | 2011 | 488 |
29 | Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System | Toxicologic Pathology | 2010 | 468 |
30 | Phytoestrogens and Their Human Metabolites Show Distinct Agonistic and Antagonistic Properties on Estrogen Receptor (ER ) and ER in Human Cells | Toxicological Sciences | 2004 | 452 |
31 | Effects of different head groups and functionalised side chains on the aquatic toxicity of ionic liquids | Green Chemistry | 2007 | 425 |
32 | Applications of silica-based monolithic HPLC columns | Journal of Separation Science | 2004 | 385 |
33 | Nematic Liquid Crystals for Active Matrix Displays: Molecular Design and Synthesis | Angewandte Chemie - International Edition | 2000 | 378 |
34 | Combining Global and Local Measures for Structure-Based Druggability Predictions | Journal of Chemical Information and Modeling | 2012 | 346 |
35 | Efficacy of modified-release versus standard prednisone to reduce duration of morning stiffness of the joints in rheumatoid arthritis (CAPRA-1): a double-blind, randomised controlled trial | Lancet, The | 2008 | 340 |
36 | Liver Hypertrophy | Toxicologic Pathology | 2012 | 336 |
37 | Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor–type integrins inhibits retinal neovascularization | Nature Medicine | 1996 | 326 |
38 | Consequences of Optimal Bond Valence on Structural Rigidity and Improved Luminescence Properties in SrxBa2–xSiO4:Eu2+ Orthosilicate Phosphors | Chemistry of Materials | 2014 | 323 |
39 | Immunohistochemical Detection of EGFR in Paraffin-embedded Tumor Tissues | Journal of Histochemistry and Cytochemistry | 2004 | 317 |
40 | Anion effects on the cytotoxicity of ionic liquids | Green Chemistry | 2006 | 312 |
41 | Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis | Journal of Experimental Medicine | 2008 | 312 |
42 | The influence of anion species on the toxicity of 1-alkyl-3-methylimidazolium ionic liquids observed in an (eco)toxicological test battery | Green Chemistry | 2007 | 309 |
43 | Merkel cell carcinoma: Epidemiology, prognosis, therapy and unmet medical needs | European Journal of Cancer | 2017 | 307 |
44 | A New Monolithic-Type HPLC Column For Fast Separations | Journal of High Resolution Chromatography | 2000 | 306 |
45 | On the capacity fading of LiCoO2 intercalation electrodes: | Electrochimica Acta | 2002 | 305 |
46 | Phase I Trial of M7824 (MSB0011359C), a Bifunctional Fusion Protein Targeting PD-L1 and TGFβ, in Advanced Solid Tumors | Clinical Cancer Research | 2018 | 304 |
47 | Efficacy and Safety of First-line Avelumab Treatment in Patients With Stage IV Metastatic Merkel Cell Carcinoma | JAMA Oncology | 2018 | 304 |
48 | Efficacy and Safety of Avelumab for Patients With Recurrent or Refractory Ovarian Cancer | JAMA Oncology | 2019 | 303 |
49 | Monolithic Silica Columns for HPLC, Micro-HPLC, and CEC | Journal of High Resolution Chromatography | 2000 | 299 |
50 | Her-2 Overexpression Increases the Metastatic Outgrowth of Breast Cancer Cells in the Brain | Cancer Research | 2007 | 299 |