| # | Title | Journal | Year | Citations |
|---|
| 1 | U-Net: Convolutional Networks for Biomedical Image Segmentation | Lecture Notes in Computer Science | 2015 | 27,139 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | deepTools2: a next generation web server for deep-sequencing data analysis | Nucleic Acids Research | 2016 | 5,157 |
| 4 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 5 | Function and Activation of NF-kappaB in the Immune System | Annual Review of Immunology | 1994 | 4,653 |
| 6 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 7 | Activators and target genes of Rel/NF-κB transcription factors | Oncogene | 1999 | 3,586 |
| 8 | Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs | Science | 1997 | 3,420 |
| 9 | Mindfulness-based stress reduction and health benefits | Journal of Psychosomatic Research | 2004 | 3,316 |
| 10 | Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis | New England Journal of Medicine | 2002 | 3,048 |
| 11 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,697 |
| 12 | How to perform a meta-analysis with R: a practical tutorial | Evidence-Based Mental Health | 2019 | 2,476 |
| 13 | deepTools: a flexible platform for exploring deep-sequencing data | Nucleic Acids Research | 2014 | 2,380 |
| 14 | FlowNet: Learning Optical Flow with Convolutional Networks | | 2015 | 2,361 |
| 15 | Host microbiota constantly control maturation and function of microglia in the CNS | Nature Neuroscience | 2015 | 2,340 |
| 16 | Angiotensin-converting enzyme 2 protects from severe acute lung failure | Nature | 2005 | 2,264 |
| 17 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 18 | A benchmark for the evaluation of RGB-D SLAM systems | | 2012 | 2,188 |
| 19 | A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells | Science | 2012 | 2,084 |
| 20 | An updated evolutionary classification of CRISPR–Cas systems | Nature Reviews Microbiology | 2015 | 2,081 |
| 21 | Engineering the Provitamin A (-Carotene) Biosynthetic Pathway into (Carotenoid-Free) Rice Endosperm | Science | 2000 | 2,067 |
| 22 | Innate lymphoid cells — a proposal for uniform nomenclature | Nature Reviews Immunology | 2013 | 2,054 |
| 23 | The NALP3 inflammasome is involved in the innate immune response to amyloid-β | Nature Immunology | 2008 | 2,047 |
| 24 | RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates | Science | 2006 | 1,965 |
| 25 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 26 | Quantitative sensory testing in the German Research Network on Neuropathic Pain (DFNS): Standardized protocol and reference values | Pain | 2006 | 1,939 |
| 27 | The atomic simulation environment—a Python library for working with atoms | Journal of Physics Condensed Matter | 2017 | 1,933 |
| 28 | OctoMap: an efficient probabilistic 3D mapping framework based on octrees | Autonomous Robots | 2013 | 1,932 |
| 29 | FlowNet 2.0: Evolution of Optical Flow Estimation with Deep Networks | | 2017 | 1,888 |
| 30 | DNA methylation-based classification of central nervous system tumours | Nature | 2018 | 1,872 |
| 31 | ESPEN guidelines on nutrition in cancer patients | Clinical Nutrition | 2017 | 1,855 |
| 32 | RARE imaging: A fast imaging method for clinical MR | Magnetic Resonance in Medicine | 1986 | 1,825 |
| 33 | Improved Techniques for Grid Mapping With Rao-Blackwellized Particle Filters | | 2007 | 1,766 |
| 34 | CasADi: a software framework for nonlinear optimization and optimal control | Mathematical Programming Computation | 2019 | 1,745 |
| 35 | The Physcomitrella Genome Reveals Evolutionary Insights into the Conquest of Land by Plants | Science | 2008 | 1,712 |
| 36 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 37 | Deep learning with convolutional neural networks for EEG decoding and visualization | Human Brain Mapping | 2017 | 1,656 |
| 38 | Efficacy and safety of intravenous levosimendan compared with dobutamine in severe low-output heart failure (the LIDO study): a randomised double-blind trial | Lancet, The | 2002 | 1,621 |
| 39 | Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions | Nature Neuroscience | 2019 | 1,589 |
| 40 | A reciprocal repression between ZEB1 and members of the miR‐200 family promotes EMT and invasion in cancer cells | EMBO Reports | 2008 | 1,567 |
| 41 | The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs | Nature Cell Biology | 2009 | 1,547 |
| 42 | Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma | Nature | 2007 | 1,446 |
| 43 | Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia | Cell | 1997 | 1,435 |
| 44 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 45 | Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine | Nature Reviews Neuroscience | 2011 | 1,422 |
| 46 | Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9 | Cell | 1994 | 1,417 |
| 47 | Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications | Chemical Society Reviews | 2010 | 1,366 |
| 48 | Robust Monte Carlo localization for mobile robots | Artificial Intelligence | 2001 | 1,359 |
| 49 | European guideline for the diagnosis and treatment of insomnia | Journal of Sleep Research | 2017 | 1,334 |
| 50 | Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps | Nature Genetics | 2018 | 1,331 |
