| # | Title | Journal | Year | Citations |
|---|
| 1 | Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial | Lancet Oncology, The | 2009 | 5,104 |
| 2 | Poly(3,4-ethylenedioxythiophene) and Its Derivatives: Past, Present, and Future | Advanced Materials | 2000 | 3,057 |
| 3 | Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 2,771 |
| 4 | Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration | Ophthalmology | 2012 | 1,947 |
| 5 | A new approach to practical acute toxicity testing | Archives of Toxicology | 1983 | 1,932 |
| 6 | Refinement and Parametrization of COSMO-RS | Journal of Physical Chemistry A | 1998 | 1,577 |
| 7 | Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial | Lancet, The | 2014 | 1,295 |
| 8 | Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling | Molecular Cancer Therapeutics | 2008 | 1,237 |
| 9 | Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity | International Journal of Cancer | 2011 | 1,068 |
| 10 | Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing | Nature Medicine | 2018 | 1,044 |
| 11 | Molecular imaging in drug development | Nature Reviews Drug Discovery | 2008 | 1,000 |
| 12 | Poly(alkylenedioxythiophene)s—new, very stable conducting polymers | Advanced Materials | 1992 | 958 |
| 13 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial | Lancet, The | 2009 | 898 |
| 14 | Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial | Lancet Oncology, The | 2015 | 809 |
| 15 | Incorporation of solvent effects into density functional calculations of molecular energies and geometries | Journal of Chemical Physics | 1995 | 776 |
| 16 | Treatment of the outlying charge in continuum solvation models | Journal of Chemical Physics | 1996 | 771 |
| 17 | The strychnine-binding subunit of the glycine receptor shows homology with nicotinic acetylcholine receptors | Nature | 1987 | 754 |
| 18 | Efficacy and safety of sorafenib in patients with advanced hepatocellular carcinoma: Subanalyses of a phase III trial | Journal of Hepatology | 2012 | 736 |
| 19 | Mechanical properties and electrical conductivity of carbon-nanotube filled polyamide-6 and its blends with acrylonitrile/butadiene/styrene | Polymer | 2004 | 673 |
| 20 | Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial | Lancet, The | 2018 | 651 |
| 21 | COSMO Implementation in TURBOMOLE: Extension of an efficient quantum chemical code towards liquid systems | Physical Chemistry Chemical Physics | 2000 | 632 |
| 22 | CD8+ T-cell responses to adeno-associated virus capsid in humans | Nature Medicine | 2007 | 629 |
| 23 | Disease resistance results from foreign phytoalexin expression in a novel plant | Nature | 1993 | 621 |
| 24 | Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial | Lancet, The | 2018 | 619 |
| 25 | Critically evaluated rate coefficients for free-radical polymerization, 1. Propagation rate coefficient for styrene | Macromolecular Chemistry and Physics | 1995 | 617 |
| 26 | Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials | Lancet Oncology, The | 2020 | 608 |
| 27 | Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism | New England Journal of Medicine | 2017 | 577 |
| 28 | Epidemiology of uterine fibroids: a systematic review | BJOG: an International Journal of Obstetrics and Gynaecology | 2017 | 571 |
| 29 | Sorafenib or placebo plus TACE with doxorubicin-eluting beads for intermediate stage HCC: The SPACE trial | Journal of Hepatology | 2016 | 567 |
| 30 | Application of palladacycles in Heck type reactions | Journal of Organometallic Chemistry | 1999 | 563 |
| 31 | Critically evaluated rate coefficients for free-radical polymerization, 2.. Propagation rate coefficients for methyl methacrylate | Macromolecular Chemistry and Physics | 1997 | 524 |
| 32 | Statistical Investigation into the Structural Complementarity of Natural Products and Synthetic Compounds | Angewandte Chemie - International Edition | 1999 | 519 |
| 33 | NO-independent regulatory site on soluble guanylate cyclase | Nature | 2001 | 512 |
| 34 | Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma | European Journal of Cancer | 2011 | 496 |
| 35 | Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study | Lancet Neurology, The | 2011 | 491 |
| 36 | Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury | BMC Neuroscience | 2002 | 489 |
| 37 | Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C | Investigative Radiology | 2008 | 476 |
| 38 | Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration | British Journal of Ophthalmology | 2015 | 474 |
| 39 | Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the BENEFIT study | Lancet, The | 2007 | 468 |
| 40 | Prognostic factors and predictors of sorafenib benefit in patients with hepatocellular carcinoma: Analysis of two phase III studies | Journal of Hepatology | 2017 | 465 |
| 41 | 4-Aryldihydropyridines, a New Class of Highly Active Calcium Antagonists | Angewandte Chemie International Edition in English | 1981 | 443 |
| 42 | Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages | Science Translational Medicine | 2011 | 442 |
| 43 | 1,4-Dihydropyridines: Effects of Chirality and Conformation on the Calcium Antagonist and Calcium Agonist Activities | Angewandte Chemie International Edition in English | 1991 | 435 |
| 44 | Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial | Lancet, The | 2018 | 426 |
| 45 | Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking☆ | Gastroenterology | 2004 | 418 |
| 46 | Glucosidase inhibition | Die Naturwissenschaften | 1977 | 413 |
| 47 | Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 408 |
| 48 | Concordance between administrative claims and registry data for identifying metastasis to the bone: an exploratory analysis in prostate cancer | BMC Medical Research Methodology | 2014 | 403 |
| 49 | Vitamin D as an Early Predictor of Multiple Sclerosis Activity and Progression | JAMA Neurology | 2014 | 402 |
| 50 | Using OrthoMCL to Assign Proteins to OrthoMCL‐DB Groups or to Cluster Proteomes Into New Ortholog Groups | Current Protocols in Bioinformatics | 2011 | 397 |
