| # | Title | Journal | Year | Citations |
|---|
| 1 | PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer | Breast Care | 2016 | 20,872 |
| 2 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 3 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 4 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 5 | Planck2015 results | Astronomy and Astrophysics | 2016 | 8,344 |
| 6 | Primer3—new capabilities and interfaces | Nucleic Acids Research | 2012 | 7,501 |
| 7 | Sarcopenia: revised European consensus on definition and diagnosis | Age and Ageing | 2019 | 6,824 |
| 8 | Complex heatmaps reveal patterns and correlations in multidimensional genomic data | Bioinformatics | 2016 | 5,891 |
| 9 | Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke | New England Journal of Medicine | 2008 | 5,749 |
| 10 | Hepatic platelet and leukocyte adherence during endotoxemia | Critical Care | 2006 | 5,093 |
| 11 | Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 4,751 |
| 12 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 13 | Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines | Immunity | 2014 | 4,638 |
| 14 | The 2021 WHO Classification of Tumors of the Central Nervous System: a summary | Neuro-Oncology | 2021 | 4,534 |
| 15 | HEALPix: A Framework for High‐Resolution Discretization and Fast Analysis of Data Distributed on the Sphere | Astrophysical Journal | 2005 | 4,312 |
| 16 | Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke | New England Journal of Medicine | 2015 | 4,255 |
| 17 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015 | JAMA Oncology | 2017 | 4,254 |
| 18 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 19 | The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP) | Radiocarbon | 2020 | 3,502 |
| 20 | International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma | Lancet Oncology, The | 2014 | 3,343 |
| 21 | Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia | New England Journal of Medicine | 2003 | 3,227 |
| 22 | Developmental and regional expression in the rat brain and functional properties of four NMDA receptors | Neuron | 1994 | 3,218 |
| 23 | Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II) | Lancet, The | 1998 | 3,216 |
| 24 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 25 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 26 | Anxiety Disorders in Primary Care: Prevalence, Impairment, Comorbidity, and Detection | Annals of Internal Medicine | 2007 | 3,084 |
| 27 | Comparative Analysis of Mesenchymal Stem Cells from Bone Marrow, Umbilical Cord Blood, or Adipose Tissue | Stem Cells | 2006 | 2,851 |
| 28 | circlizeimplements and enhances circular visualization in R | Bioinformatics | 2014 | 2,736 |
| 29 | Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease | Nature Genetics | 2009 | 2,697 |
| 30 | Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells | Nature Medicine | 1998 | 2,689 |
| 31 | The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After | Surgery | 2017 | 2,655 |
| 32 | Discovery and refinement of loci associated with lipid levels | Nature Genetics | 2013 | 2,641 |
| 33 | Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events | New England Journal of Medicine | 2006 | 2,582 |
| 34 | Family history of subarachnoid haemorrhage: supplemental value of scrutinizing all relatives. | Journal of Neurology, Neurosurgery and Psychiatry | 1997 | 2,568 |
| 35 | Production of infectious hepatitis C virus in tissue culture from a cloned viral genome | Nature Medicine | 2005 | 2,561 |
| 36 | Advances in molecular quantum chemistry contained in the Q-Chem 4 program package | Molecular Physics | 2015 | 2,561 |
| 37 | Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study | Lancet, The | 2007 | 2,527 |
| 38 | Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes | Science | 1992 | 2,425 |
| 39 | Transcriptional activation by tetracyclines in mammalian cells | Science | 1995 | 2,391 |
| 40 | Hsp70 chaperones: Cellular functions and molecular mechanism | Cellular and Molecular Life Sciences | 2005 | 2,356 |
| 41 | Delayed gastric emptying (DGE) after pancreatic surgery: A suggested definition by the International Study Group of Pancreatic Surgery (ISGPS) | Surgery | 2007 | 2,293 |
| 42 | Genomic correlates of response to CTLA-4 blockade in metastatic melanoma | Science | 2015 | 2,275 |
| 43 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 44 | Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression | Nature Genetics | 2018 | 2,224 |
| 45 | Environmental sensing through focal adhesions | Nature Reviews Molecular Cell Biology | 2009 | 2,205 |
| 46 | Present and Future of Surface-Enhanced Raman Scattering | ACS Nano | 2020 | 2,153 |
| 47 | Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus | Nature | 2005 | 2,136 |
| 48 | MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts | Nature | 2008 | 2,111 |
| 49 | ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition | Nature Chemical Biology | 2017 | 2,069 |
| 50 | The multiconfiguration time-dependent Hartree (MCTDH) method: a highly efficient algorithm for propagating wavepackets | Physics Reports | 2000 | 2,065 |
