| # | Title | Journal | Year | Citations |
|---|
| 1 | Ant system: optimization by a colony of cooperating agents | IEEE Transactions on Systems, Man, and Cybernetics | 1996 | 8,864 |
| 2 | Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity | NeuroSignals | 2013 | 7,097 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Ru(II) polypyridine complexes: photophysics, photochemistry, eletrochemistry, and chemiluminescence | Coordination Chemistry Reviews | 1988 | 4,615 |
| 5 | Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy | JAMA - Journal of the American Medical Association | 2020 | 4,411 |
| 6 | Inflamm‐aging: An Evolutionary Perspective on Immunosenescence | Annals of the New York Academy of Sciences | 2000 | 3,854 |
| 7 | Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial | Lancet, The | 2018 | 3,542 |
| 8 | The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP) | Radiocarbon | 2020 | 3,502 |
| 9 | Imatinib Compared with Interferon and Low-Dose Cytarabine for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia | New England Journal of Medicine | 2003 | 3,227 |
| 10 | Five-Year Follow-up of Patients Receiving Imatinib for Chronic Myeloid Leukemia | New England Journal of Medicine | 2006 | 3,212 |
| 11 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 12 | Networks on chips: a new SoC paradigm | Computer | 2002 | 3,027 |
| 13 | A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus Beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae | International Journal of Systematic and Evolutionary Microbiology | 2020 | 2,775 |
| 14 | Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial | Lancet, The | 2017 | 2,771 |
| 15 | ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion—part I: ankle, hip, and spine | Journal of Biomechanics | 2002 | 2,491 |
| 16 | Metaheuristics in combinatorial optimization | ACM Computing Surveys | 2003 | 2,445 |
| 17 | Shifting the limits in wheat research and breeding using a fully annotated reference genome | Science | 2018 | 2,424 |
| 18 | International uniform response criteria for multiple myeloma | Leukemia | 2006 | 2,332 |
| 19 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome | Hepatology | 2003 | 2,276 |
| 20 | The Global Burden of Cancer 2013 | JAMA Oncology | 2015 | 2,269 |
| 21 | Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension | New England Journal of Medicine | 2005 | 2,237 |
| 22 | Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of Cirrhosis | Gastroenterology | 2013 | 2,211 |
| 23 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 24 | Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome | Diabetes | 2001 | 2,100 |
| 25 | Management ofHelicobacter pyloriinfection—the Maastricht IV/ Florence Consensus Report | Gut | 2012 | 2,023 |
| 26 | 2020 International Society of Hypertension Global Hypertension Practice Guidelines | Hypertension | 2020 | 1,895 |
| 27 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance | Biochimica Et Biophysica Acta - Molecular Cell Research | 2007 | 1,858 |
| 28 | Market Size, Trade, and Productivity | Review of Economic Studies | 2008 | 1,847 |
| 29 | Characterization of polyploid wheat genomic diversity using a high‐density 90 000 single nucleotide polymorphism array | Plant Biotechnology Journal | 2014 | 1,828 |
| 30 | Functional impact of global rare copy number variation in autism spectrum disorders | Nature | 2010 | 1,803 |
| 31 | Surface modification of inorganic nanoparticles for development of organic–inorganic nanocomposites—A review | Progress in Polymer Science | 2013 | 1,760 |
| 32 | Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty | Nature Reviews Cardiology | 2018 | 1,760 |
| 33 | Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans | Mechanisms of Ageing and Development | 2007 | 1,759 |
| 34 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013 | Blood | 2013 | 1,743 |
| 35 | Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial | Lancet, The | 2010 | 1,713 |
| 36 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 37 | Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017 | JAMA Oncology | 2019 | 1,691 |
| 38 | The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications | Blood | 2011 | 1,681 |
| 39 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2022 | 1,679 |
| 40 | Inflammaging: a new immune–metabolic viewpoint for age-related diseases | Nature Reviews Endocrinology | 2018 | 1,643 |
| 41 | Luminescent lanthanide complexes as photochemical supramolecular devices | Coordination Chemistry Reviews | 1993 | 1,597 |
| 42 | Simplified criteria for the diagnosis of autoimmune hepatitis | Hepatology | 2008 | 1,553 |
| 43 | A test of general relativity using radio links with the Cassini spacecraft | Nature | 2003 | 1,547 |
| 44 | 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn’s Disease 2016: Part 1: Diagnosis and Medical Management | Journal of Crohn's and Colitis | 2017 | 1,547 |
| 45 | EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer—2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent | European Urology | 2021 | 1,545 |
| 46 | Clinical classification of pulmonary hypertension | Journal of the American College of Cardiology | 2004 | 1,542 |
| 47 | The Future of Energy Supply: Challenges and Opportunities | Angewandte Chemie - International Edition | 2007 | 1,534 |
| 48 | Biodegradable polymers for food packaging: a review | Trends in Food Science and Technology | 2008 | 1,534 |
| 49 | Dark Matter Search Results from a One Ton-Year Exposure of XENON1T | Physical Review Letters | 2018 | 1,517 |
| 50 | I-Mutant2.0: predicting stability changes upon mutation from the protein sequence or structure | Nucleic Acids Research | 2005 | 1,502 |
