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Top Articles

#TitleJournalYearCitations
1Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelinesJournal of Extracellular Vesicles20186,961
2Expert consensus document on arterial stiffness: methodological issues and clinical applicationsEuropean Heart Journal20065,012
3The Unfolded Protein Response: From Stress Pathway to Homeostatic RegulationScience20114,768
4The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature20124,708
5Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy20164,701
6Host–microbe interactions have shaped the genetic architecture of inflammatory bowel diseaseNature20124,038
7Multiple sclerosisLancet, The20083,988
8Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegenerationLancet Neurology, The20133,919
9Biological, clinical and population relevance of 95 loci for blood lipidsNature20103,249
10Induction of autophagy and inhibition of tumorigenesis by beclin 1Nature19992,991
11Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesisDiabetologia19922,938
12Correlates of physical activity: why are some people physically active and others not?Lancet, The20122,874
13Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic CancerScience20092,730
14Congenital leptin deficiency is associated with severe early-onset obesity in humansNature19972,664
15Discovery and refinement of loci associated with lipid levelsNature Genetics20132,641
16Association analyses of 249,796 individuals reveal 18 new loci associated with body mass indexNature Genetics20102,634
17TFEB Links Autophagy to Lysosomal BiogenesisScience20112,513
18Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's diseaseNature Genetics20082,422
19Fetal and infant growth and impaired glucose tolerance at age 64.BMJ: British Medical Journal19912,326
20Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility lociNature Genetics20102,284
21Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growthDiabetologia19932,271
22A Resilient, Low-Frequency, Small-World Human Brain Functional Network with Highly Connected Association Cortical HubsJournal of Neuroscience20062,211
23The thrifty phenotype hypothesisBritish Medical Bulletin20012,196
24Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseNature Genetics20042,188
25Common regions of the human frontal lobe recruited by diverse cognitive demandsTrends in Neurosciences20002,158
26Small-World Brain NetworksNeuroscientist20062,140
2710-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate CancerNew England Journal of Medicine20162,101
28Efficiency and Cost of Economical Brain Functional NetworksPLoS Computational Biology20072,100
29Albuminuria and Risk of Cardiovascular Events, Death, and Heart Failure in Diabetic and Nondiabetic IndividualsJAMA - Journal of the American Medical Association20012,067
30Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer DevelopmentCell20112,020
31Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROSNature20141,989
32New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes riskNature Genetics20101,982
33Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populationsNature Genetics20151,965
34Osteoporosis in the European Union: medical management, epidemiology and economic burdenArchives of Osteoporosis20131,932
35Magnetic resonance elastography by direct visualization of propagating acoustic strain wavesScience19951,879
36Derivation of pluripotent epiblast stem cells from mammalian embryosNature20071,842
37Defining the role of common variation in the genomic and biological architecture of adult human heightNature Genetics20141,818
38Autophagy and AgingCell20111,809
39Multiple sclerosisLancet, The20021,792
40Hundreds of variants clustered in genomic loci and biological pathways affect human heightNature20101,789
41SEMANTIC DEMENTIABrain19921,786
42Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin DeficiencyNew England Journal of Medicine19991,760
43Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetesNature Genetics20081,683
44Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein–Coupled Receptor FFAR2Diabetes20121,644
45Twelve type 2 diabetes susceptibility loci identified through large-scale association analysisNature Genetics20101,631
46The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screeningInternational Journal of Geriatric Psychiatry20061,619
47DECIPHER: Database of Chromosomal Imbalance and Phenotype in Humans Using Ensembl ResourcesAmerican Journal of Human Genetics20091,614
48`Oops!': Performance correlates of everyday attentional failures in traumatic brain injured and normal subjectsNeuropsychologia19971,603
49Regulation of Mammalian Autophagy in Physiology and PathophysiologyPhysiological Reviews20101,557
50Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesNature Genetics20091,513