| # | Title | Journal | Year | Citations |
|---|
| 1 | PHENIX: a comprehensive Python-based system for macromolecular structure solution | Acta Crystallographica Section D: Biological Crystallography | 2010 | 20,564 |
| 2 | COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARIS | Plant Physiology | 1949 | 19,369 |
| 3 | Phasercrystallographic software | Journal of Applied Crystallography | 2007 | 17,782 |
| 4 | Raman Spectrum of Graphene and Graphene Layers | Physical Review Letters | 2006 | 12,689 |
| 5 | Interpretation of Raman spectra of disordered and amorphous carbon | Physical Review B | 2000 | 12,419 |
| 6 | A new hybrid exchange–correlation functional using the Coulomb-attenuating method (CAM-B3LYP) | Chemical Physics Letters | 2004 | 11,492 |
| 7 | SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation | IEEE Transactions on Pattern Analysis and Machine Intelligence | 2017 | 11,162 |
| 8 | Overview of theCCP4 suite and current developments | Acta Crystallographica Section D: Biological Crystallography | 2011 | 11,098 |
| 9 | Array programming with NumPy | Nature | 2020 | 10,143 |
| 10 | A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 9,397 |
| 11 | Complex brain networks: graph theoretical analysis of structural and functional systems | Nature Reviews Neuroscience | 2009 | 9,369 |
| 12 | Chromatin Modifications and Their Function | Cell | 2007 | 9,258 |
| 13 | A Film Detection Method for Tritium-Labelled Proteins and Nucleic Acids in Polyacrylamide Gels | FEBS Journal | 1974 | 9,250 |
| 14 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013 | Lancet, The | 2014 | 9,122 |
| 15 | A tutorial on particle filters for online nonlinear/non-Gaussian Bayesian tracking | IEEE Transactions on Signal Processing | 2002 | 8,786 |
| 16 | First-principles simulation: ideas, illustrations and the CASTEP code | Journal of Physics Condensed Matter | 2002 | 8,382 |
| 17 | Planck2015 results | Astronomy and Astrophysics | 2016 | 8,344 |
| 18 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,060 |
| 19 | Establishment in culture of pluripotential cells from mouse embryos | Nature | 1981 | 7,627 |
| 20 | α-Synuclein in Lewy bodies | Nature | 1997 | 7,181 |
| 21 | Multiferroic and magnetoelectric materials | Nature | 2006 | 7,032 |
| 22 | A simple panel unit root test in the presence of cross-section dependence | Journal of Applied Econometrics | 2007 | 7,020 |
| 23 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 24 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 6,753 |
| 25 | Graphene photonics and optoelectronics | Nature Photonics | 2010 | 6,719 |
| 26 | Inositol trisphosphate and calcium signalling | Nature | 1993 | 6,715 |
| 27 | GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral | Physical Review Letters | 2017 | 6,413 |
| 28 | Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 | Lancet, The | 2012 | 6,376 |
| 29 | Raman spectroscopy of graphene and graphite: Disorder, electron–phonon coupling, doping and nonadiabatic effects | Solid State Communications | 2007 | 6,322 |
| 30 | Multiple imputation using chained equations: Issues and guidance for practice | Statistics in Medicine | 2011 | 6,168 |
| 31 | Inositol trisphosphate, a novel second messenger in cellular signal transduction | Nature | 1984 | 6,124 |
| 32 | Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis | Annals of Neurology | 2001 | 6,122 |
| 33 | Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition | Diabetes Research and Clinical Practice | 2019 | 5,764 |
| 34 | Electroluminescence in conjugated polymers | Nature | 1999 | 5,746 |
| 35 | Protein Misfolding, Functional Amyloid, and Human Disease | Annual Review of Biochemistry | 2006 | 5,737 |
| 36 | Raman spectroscopy as a versatile tool for studying the properties of graphene | Nature Nanotechnology | 2013 | 5,652 |
| 37 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 38 | High-yield production of graphene by liquid-phase exfoliation of graphite | Nature Nanotechnology | 2008 | 5,431 |
| 39 | A review of methods for the assessment of prediction errors in conservation presence/absence models | Environmental Conservation | 1997 | 5,361 |
| 40 | Emerging applications of stimuli-responsive polymer materials | Nature Materials | 2010 | 5,007 |
| 41 | The Behavior Change Technique Taxonomy (v1) of 93 Hierarchically Clustered Techniques: Building an International Consensus for the Reporting of Behavior Change Interventions | Annals of Behavioral Medicine | 2013 | 4,927 |
| 42 | Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography | FEBS Journal | 1975 | 4,904 |
| 43 | The autism-spectrum quotient (AQ): evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians | Journal of Autism and Developmental Disorders | 2001 | 4,773 |
| 44 | The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation | Science | 2011 | 4,768 |
| 45 | The DNA-damage response in human biology and disease | Nature | 2009 | 4,718 |
| 46 | The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups | Nature | 2012 | 4,708 |
| 47 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 48 | Dementia prevention, intervention, and care: 2020 report of the Lancet Commission | Lancet, The | 2020 | 4,658 |
| 49 | Global prevalence of dementia: a Delphi consensus study | Lancet, The | 2005 | 4,496 |
| 50 | UCSF ChimeraX: Structure visualization for researchers, educators, and developers | Protein Science | 2021 | 4,478 |
