| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement | PLoS Medicine | 2009 | 52,826 |
| 2 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 39,671 |
| 3 | The PHQ-9 | Journal of General Internal Medicine | 2001 | 31,261 |
| 4 | Quantifying heterogeneity in a meta‐analysis | Statistics in Medicine | 2002 | 28,855 |
| 5 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 27,827 |
| 6 | Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) | JAMA - Journal of the American Medical Association | 2001 | 24,891 |
| 7 | Clinical Characteristics of Coronavirus Disease 2019 in China | New England Journal of Medicine | 2020 | 23,390 |
| 8 | The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes Mellitus | New England Journal of Medicine | 1993 | 23,023 |
| 9 | A Novel Coronavirus from Patients with Pneumonia in China, 2019 | New England Journal of Medicine | 2020 | 22,453 |
| 10 | A Global Measure of Perceived Stress | Journal of Health and Social Behavior | 1983 | 22,121 |
| 11 | Atherosclerosis — An Inflammatory Disease | New England Journal of Medicine | 1999 | 19,904 |
| 12 | Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China | JAMA - Journal of the American Medical Association | 2020 | 18,687 |
| 13 | Antioxidant activity applying an improved ABTS radical cation decolorization assay | Free Radical Biology and Medicine | 1999 | 18,632 |
| 14 | The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE> | JAMA - Journal of the American Medical Association | 2003 | 18,266 |
| 15 | Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma | New England Journal of Medicine | 2005 | 17,987 |
| 16 | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) | JAMA - Journal of the American Medical Association | 2016 | 17,870 |
| 17 | Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE> | JAMA - Journal of the American Medical Association | 2000 | 17,789 |
| 18 | Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin | New England Journal of Medicine | 2002 | 16,280 |
| 19 | phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data | PLoS ONE | 2013 | 15,280 |
| 20 | Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China | JAMA - Journal of the American Medical Association | 2020 | 14,902 |
| 21 | Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial | JAMA - Journal of the American Medical Association | 2002 | 14,686 |
| 22 | Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome | New England Journal of Medicine | 2000 | 14,638 |
| 23 | Intensive Insulin Therapy in Critically Ill Patients | New England Journal of Medicine | 2001 | 14,397 |
| 24 | The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration | PLoS Medicine | 2009 | 14,265 |
| 25 | Improved Survival with Ipilimumab in Patients with Metastatic Melanoma | New England Journal of Medicine | 2010 | 13,352 |
| 26 | Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock | New England Journal of Medicine | 2001 | 13,057 |
| 27 | Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia | New England Journal of Medicine | 2020 | 12,803 |
| 28 | Sorafenib in Advanced Hepatocellular Carcinoma | New England Journal of Medicine | 2008 | 12,555 |
| 29 | Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine | New England Journal of Medicine | 2020 | 12,150 |
| 30 | FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments | PLoS ONE | 2010 | 12,018 |
| 31 | Tissue Plasminogen Activator for Acute Ischemic Stroke | New England Journal of Medicine | 1995 | 11,478 |
| 32 | Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer | New England Journal of Medicine | 2012 | 10,985 |
| 33 | Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib | New England Journal of Medicine | 2004 | 10,727 |
| 34 | Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2 | New England Journal of Medicine | 2001 | 10,377 |
| 35 | Studies of Illness in the Aged | JAMA - Journal of the American Medical Association | 1963 | 10,050 |
| 36 | Dabigatran versus Warfarin in Patients with Atrial Fibrillation | New England Journal of Medicine | 2009 | 10,018 |
| 37 | Chronic Kidney Disease and the Risks of Death, Cardiovascular Events, and Hospitalization | New England Journal of Medicine | 2004 | 10,013 |
| 38 | AFNI: Software for Analysis and Visualization of Functional Magnetic Resonance Neuroimages | Journal of Biomedical Informatics | 1996 | 9,969 |
| 39 | Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer | New England Journal of Medicine | 2004 | 9,939 |
| 40 | Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes | New England Journal of Medicine | 2015 | 9,257 |
| 41 | The Occurrence of Sleep-Disordered Breathing among Middle-Aged Adults | New England Journal of Medicine | 1993 | 9,218 |
| 42 | Prevention of Type 2 Diabetes Mellitus by Changes in Lifestyle among Subjects with Impaired Glucose Tolerance | New England Journal of Medicine | 2001 | 9,194 |
| 43 | Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection | New England Journal of Medicine | 1998 | 9,034 |
| 44 | Tumor Angiogenesis: Therapeutic Implications | New England Journal of Medicine | 1971 | 8,756 |
| 45 | Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening | New England Journal of Medicine | 2011 | 8,725 |
| 46 | Projections of Global Mortality and Burden of Disease from 2002 to 2030 | PLoS Medicine | 2006 | 8,687 |
| 47 | The biology of VEGF and its receptors | Nature Medicine | 2003 | 8,620 |
| 48 | Dexamethasone in Hospitalized Patients with Covid-19 | New England Journal of Medicine | 2021 | 8,560 |
| 49 | The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies | PLoS Medicine | 2007 | 8,500 |
| 50 | The basics of epithelial-mesenchymal transition | Journal of Clinical Investigation | 2009 | 8,483 |
| 51 | THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM | Journal of Clinical Investigation | 1955 | 8,467 |
| 52 | Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis | New England Journal of Medicine | 2001 | 8,440 |
| 53 | Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine | New England Journal of Medicine | 2021 | 8,423 |
| 54 | Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid Stenosis | New England Journal of Medicine | 1991 | 8,292 |
| 55 | Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients | New England Journal of Medicine | 2000 | 8,271 |
| 56 | Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 8,230 |
| 57 | Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation | New England Journal of Medicine | 2011 | 8,213 |
| 58 | The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure | New England Journal of Medicine | 1999 | 8,196 |
| 59 | Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2016 | 8,167 |
| 60 | MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS | Statistics in Medicine | 1996 | 8,154 |
| 61 | Validation and Utility of a Self-report Version of PRIME-MD<SUBTITLE>The PHQ Primary Care Study</SUBTITLE> | JAMA - Journal of the American Medical Association | 1999 | 8,010 |
| 62 | PD-1 Blockade in Tumors with Mismatch-Repair Deficiency | New England Journal of Medicine | 2015 | 7,962 |
| 63 | Apixaban versus Warfarin in Patients with Atrial Fibrillation | New England Journal of Medicine | 2011 | 7,753 |
| 64 | Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area | JAMA - Journal of the American Medical Association | 2020 | 7,730 |
| 65 | VSEARCH: a versatile open source tool for metagenomics | PeerJ | 2016 | 7,714 |
| 66 | Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma | New England Journal of Medicine | 2009 | 7,703 |
| 67 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 7,668 |
| 68 | Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 | New England Journal of Medicine | 2020 | 7,647 |
| 69 | Computed Tomography — An Increasing Source of Radiation Exposure | New England Journal of Medicine | 2007 | 7,616 |
| 70 | Prevalence of Overweight and Obesity in the United States, 1999-2004 | JAMA - Journal of the American Medical Association | 2006 | 7,593 |
| 71 | Inflammation, Atherosclerosis, and Coronary Artery Disease | New England Journal of Medicine | 2005 | 7,560 |
| 72 | Why Most Published Research Findings Are False | PLoS Medicine | 2005 | 7,524 |
| 73 | Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2015 | 7,485 |
| 74 | Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement | PLoS ONE | 2014 | 7,325 |
| 75 | Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia | New England Journal of Medicine | 1995 | 7,297 |
| 76 | Angiogenesis in cancer, vascular, rheumatoid and other disease | Nature Medicine | 1995 | 7,296 |
| 77 | Obesity is associated with macrophage accumulation in adipose tissue | Journal of Clinical Investigation | 2003 | 7,244 |
| 78 | Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins | New England Journal of Medicine | 1998 | 7,236 |
| 79 | Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia | New England Journal of Medicine | 2002 | 7,209 |
| 80 | Structure-antioxidant activity relationships of flavonoids and phenolic acids | Free Radical Biology and Medicine | 1996 | 7,181 |
| 81 | Effects of Intensive Glucose Lowering in Type 2 Diabetes | New England Journal of Medicine | 2008 | 7,176 |
| 82 | The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels | New England Journal of Medicine | 1996 | 7,099 |
| 83 | Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation | New England Journal of Medicine | 2011 | 7,084 |
| 84 | Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest | New England Journal of Medicine | 2002 | 7,023 |
| 85 | Prevalence of Childhood and Adult Obesity in the United States, 2011-2012 | JAMA - Journal of the American Medical Association | 2014 | 7,013 |
| 86 | Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer | New England Journal of Medicine | 2012 | 7,008 |
| 87 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,992 |
| 88 | Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing | New England Journal of Medicine | 2012 | 6,910 |
| 89 | Adherence to Medication | New England Journal of Medicine | 2005 | 6,902 |
| 90 | Revisiting the Behavioral Model and Access to Medical Care: Does it Matter? | Journal of Health and Social Behavior | 1995 | 6,868 |
| 91 | Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults | New England Journal of Medicine | 2003 | 6,865 |
| 92 | An Association between Air Pollution and Mortality in Six U.S. Cities | New England Journal of Medicine | 1993 | 6,851 |
| 93 | Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure | New England Journal of Medicine | 1991 | 6,835 |
| 94 | The Epidemiology of Major Depressive Disorder | JAMA - Journal of the American Medical Association | 2003 | 6,824 |
| 95 | 2014 Evidence-Based Guideline for the Management of High Blood Pressure in Adults | JAMA - Journal of the American Medical Association | 2014 | 6,764 |
| 96 | MGMTGene Silencing and Benefit from Temozolomide in Glioblastoma | New England Journal of Medicine | 2005 | 6,739 |
| 97 | Liver Transplantation for the Treatment of Small Hepatocellular Carcinomas in Patients with Cirrhosis | New England Journal of Medicine | 1996 | 6,696 |
| 98 | Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy | New England Journal of Medicine | 2001 | 6,691 |
| 99 | Self-Rated Health and Mortality: A Review of Twenty-Seven Community Studies | Journal of Health and Social Behavior | 1997 | 6,688 |
| 100 | 10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes | New England Journal of Medicine | 2008 | 6,683 |
