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Top Articles

#TitleJournalYearCitations
1Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseHepatology20058,518
2Preoperative assessment of liver function: a comparison of 99mTc-Mebrofenin scintigraphy with indocyanine green clearance testLiver International20047,546
3Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomesHepatology20167,346
4Management of hepatocellular carcinoma: An updateHepatology20117,111
5EASL Clinical Practice Guidelines: Management of hepatocellular carcinomaJournal of Hepatology20186,153
6The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probioticNature Reviews Gastroenterology and Hepatology20145,773
7Management of hepatocellular carcinomaHepatology20055,426
8EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinomaJournal of Hepatology20125,214
9Hepatocellular Carcinoma: Epidemiology and Molecular CarcinogenesisGastroenterology20074,828
10The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver DiseasesHepatology20184,738
11Histological grading and staging of chronic hepatitisJournal of Hepatology19954,685
12Functional Bowel DisordersGastroenterology20064,197
13A model to predict survival in patients with end-stage liver diseaseHepatology20014,112
14Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic ReviewGastroenterology20124,013
15Clinical Management of Hepatocellular Carcinoma. Conclusions of the Barcelona-2000 EASL ConferenceJournal of Hepatology20013,959
16EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infectionJournal of Hepatology20173,803
17Steatohepatitis: A tale of two “hits”?Gastroenterology19983,644
18An algorithm for the grading of activity in chronic hepatitis CHepatology19963,593
19Global burden of NAFLD and NASH: trends, predictions, risk factors and preventionNature Reviews Gastroenterology and Hepatology20183,487
20A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis CHepatology20033,455
21EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver diseaseJournal of Hepatology20163,403
22Prognosis of Hepatocellular Carcinoma: The BCLC Staging ClassificationSeminars in Liver Disease19993,350
23Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfectionHepatology20063,343
24Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitisHepatology19813,336
25Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicityHepatology20043,250
26Modified RECIST (mRECIST) Assessment for Hepatocellular CarcinomaSeminars in Liver Disease20103,250
27Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological LesionsAmerican Journal of Gastroenterology19993,233
28The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based ConsensusAmerican Journal of Gastroenterology20063,207
29Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebioticsNature Reviews Gastroenterology and Hepatology20173,192
30Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver DiseasesHepatology20183,096
31Development of a Crohn's Disease Activity IndexGastroenterology19763,013
32Nonalcoholic fatty liver disease: A spectrum of clinical and pathological severity☆, ☆☆Gastroenterology19993,005
33The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological AssociationHepatology20122,935
34AASLD guidelines for the treatment of hepatocellular carcinomaHepatology20182,932
35Biology of Incretins: GLP-1 and GIPGastroenterology20072,918
36Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumGastroenterology20112,835
37EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infectionJournal of Hepatology20122,784
38Epidemiology of Viral Hepatitis and Hepatocellular CarcinomaGastroenterology20122,753
39International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitisJournal of Hepatology19992,681
40Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influencesGastroenterology20042,658
41Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survivalHepatology20032,646
42Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidanceHepatology20182,620
43Diagnosis, management, and treatment of hepatitis C: An updateHepatology20092,610
44Expanding consensus in portal hypertensionJournal of Hepatology20152,604
45Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adultsAlimentary Pharmacology and Therapeutics20112,569
46The Natural History of Nonalcoholic Fatty Liver Disease: A Population-Based Cohort StudyGastroenterology20052,544
47Chronic hepatitis B: Update 2009Hepatology20092,506
48MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular CancerGastroenterology20072,499
49A global view of hepatocellular carcinoma: trends, risk, prevention and managementNature Reviews Gastroenterology and Hepatology20192,482
50A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shuntsHepatology20002,466
51Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studiesJournal of Hepatology20062,459
52Classification of chronic hepatitis: Diagnosis, grading and stagingHepatology19942,456
53The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLDHepatology20072,448
54Chronic hepatitis BHepatology20072,422
55Mechanisms of Hepatic FibrogenesisGastroenterology20082,381
56Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomasGastroenterology19942,329
57Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinomaHepatology20022,322
58Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic SyndromeGastroenterology20122,287
59Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndromeHepatology20032,276
60Evidence for Gastrointestinal Infection of SARS-CoV-2Gastroenterology20202,222
61Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis CGastroenterology20052,216
62Model for end-stage liver disease (MELD) and allocation of donor liversGastroenterology20032,212
63Acute-on-Chronic Liver Failure Is a Distinct Syndrome That Develops in Patients With Acute Decompensation of CirrhosisGastroenterology20132,211
64The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwideJournal of Hepatology20062,205
65Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measuresJournal of Viral Hepatitis20042,202
66Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver DiseaseGastroenterology20152,200
67Primary liver cancer: Worldwide incidence and trendsGastroenterology20042,193
68Intraobserver and Interobserver Variations in Liver Biopsy Interpretation in Patients with Chronic Hepatitis CHepatology19942,184
69A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statementJournal of Hepatology20202,171
70Hepatocellular carcinoma in cirrhosis: Incidence and risk factorsGastroenterology20042,168
71Burden of liver diseases in the worldJournal of Hepatology20192,125
72Global epidemiology of hepatitis C virus infection: New estimates of age-specific antibody to HCV seroprevalenceHepatology20132,118
73Nonalcoholic fatty liver disease: From steatosis to cirrhosisHepatology20062,116
74A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in miceGastroenterology19902,091
75Review article: the role of butyrate on colonic functionAlimentary Pharmacology and Therapeutics20082,048
76International consensus guidelines 2012 for the management of IPMN and MCN of the pancreasPancreatology20122,043
77Long-term follow-up of patients with NAFLD and elevated liver enzymesHepatology20062,038
78NAFLD: A multisystem diseaseJournal of Hepatology20152,037
79Colorectal cancer screening and surveillance: Clinical guidelines and rationale?Update based on new evidenceGastroenterology20032,016
80Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of RadiologyGastroenterology20082,002
81Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM TrialGastroenterology20071,986
82Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-AnalysisGastroenterology20171,983
83Early indicators of prognosis in fulminant hepatic failureGastroenterology19891,981
84Inflammatory bowel disease: Etiology and pathogenesisGastroenterology19981,955
85Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survivalHepatology20011,931
86Characterization of the Human Colon Carcinoma Cell Line (Caco-2) as a Model System for Intestinal Epithelial PermeabilityGastroenterology19891,916
87Bowel DisordersGastroenterology20161,912
88Asian-Pacific clinical practice guidelines on the management of hepatitis B: a 2015 updateHepatology International20161,908
89Prevalence and clinical spectrum of gastroesophageal reflux: A population-based study in Olmsted County, MinnesotaGastroenterology19971,898
90The Functional Gastrointestinal Disorders and the Rome III ProcessGastroenterology20061,891
91Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infectionAmerican Journal of Gastroenterology20021,878
92Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantationHepatology19991,869
93Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesisHepatology20101,857
94Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective StudyGastroenterology20111,856
95Gluten, major histocompatibility complex, and the small intestineGastroenterology19921,853
96Nonalcoholic steatohepatitis: Association of insulin resistance and mitochondrial abnormalitiesGastroenterology20011,846
97MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver DiseaseGastroenterology20201,840
98Mechanisms of hepatic stellate cell activationNature Reviews Gastroenterology and Hepatology20171,821
99International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the PancreasPancreatology20061,805
100Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic ConferenceHepatology20031,791