# | Title | Journal | Year | Citations |
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|
1 | Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 | Nature | 1970 | 254,572 |
2 | Basic local alignment search tool | Journal of Molecular Biology | 1990 | 84,210 |
3 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 | Genome Biology | 2014 | 64,243 |
4 | Helical microtubules of graphitic carbon | Nature | 1991 | 39,609 |
5 | Detection of specific sequences among DNA fragments separated by gel electrophoresis | Journal of Molecular Biology | 1975 | 35,579 |
6 | Collective dynamics of ‘small-world’ networks | Nature | 1998 | 34,950 |
7 | [20] Processing of X-ray diffraction data collected in oscillation mode | Methods in Enzymology | 1997 | 30,489 |
8 | Electrochemical Photolysis of Water at a Semiconductor Electrode | Nature | 1972 | 29,718 |
9 | A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films | Nature | 1991 | 26,932 |
10 | clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters | OMICS A Journal of Integrative Biology | 2012 | 23,430 |
11 | Biodiversity hotspots for conservation priorities | Nature | 2000 | 22,944 |
12 | The central role of the propensity score in observational studies for causal effects | Biometrika | 1983 | 22,432 |
13 | A simple method for displaying the hydropathic character of a protein | Journal of Molecular Biology | 1982 | 22,379 |
14 | Highly accurate protein structure prediction with AlphaFold | Nature | 2021 | 22,334 |
15 | MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space | Systematic Biology | 2012 | 21,601 |
16 | Initial sequencing and analysis of the human genome | Nature | 2001 | 21,405 |
17 | Learning representations by back-propagating errors | Nature | 1986 | 20,251 |
18 | [13] Catalase in vitro | Methods in Enzymology | 1984 | 19,785 |
19 | Two-dimensional gas of massless Dirac fermions in graphene | Nature | 2005 | 19,319 |
20 | Antioxidant activity applying an improved ABTS radical cation decolorization assay | Free Radical Biology and Medicine | 1999 | 18,632 |
21 | Issues and challenges facing rechargeable lithium batteries | Nature | 2001 | 18,175 |
22 | A pneumonia outbreak associated with a new coronavirus of probable bat origin | Nature | 2020 | 17,687 |
23 | Human-level control through deep reinforcement learning | Nature | 2015 | 17,308 |
24 | Building better batteries | Nature | 2008 | 17,034 |
25 | Continuous cultures of fused cells secreting antibody of predefined specificity | Nature | 1975 | 16,812 |
26 | Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes | Genome Biology | 2002 | 16,773 |
27 | An integrated encyclopedia of DNA elements in the human genome | Nature | 2012 | 16,093 |
28 | The value of the world's ecosystem services and natural capital | Nature | 1997 | 15,878 |
29 | New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0 | Systematic Biology | 2010 | 15,775 |
30 | Double-slit photoelectron interference in strong-field ionization of the neon dimer | Nature Communications | 2019 | 15,641 |
31 | A Simple, Fast, and Accurate Algorithm to Estimate Large Phylogenies by Maximum Likelihood | Systematic Biology | 2003 | 15,623 |
32 | Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism | Nature | 1992 | 15,573 |
33 | Longitudinal data analysis using generalized linear models | Biometrika | 1986 | 15,472 |
34 | [57] Sequencing end-labeled DNA with base-specific chemical cleavages | Methods in Enzymology | 1980 | 15,338 |
35 | A global reference for human genetic variation | Nature | 2015 | 14,863 |
36 | C60: Buckminsterfullerene | Nature | 1985 | 14,852 |
37 | The genetical evolution of social behaviour. I | Journal of Theoretical Biology | 1964 | 14,566 |
38 | Model-based Analysis of ChIP-Seq (MACS) | Genome Biology | 2008 | 14,393 |
39 | An analysis of variance test for normality (complete samples) | Biometrika | 1965 | 14,384 |
40 | Differential expression analysis for sequence count data | Genome Biology | 2010 | 14,141 |
41 | Molecular portraits of human breast tumours | Nature | 2000 | 13,655 |
42 | U1 snRNP regulates cancer cell migration and invasion in vitro | Nature Communications | 2020 | 13,413 |
43 | Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans | Nature | 1998 | 13,355 |
44 | Dendritic cells and the control of immunity | Nature | 1998 | 13,193 |
45 | Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I | Journal of Molecular Biology | 1977 | 13,094 |
46 | Structural absorption by barbule microstructures of super black bird of paradise feathers | Nature Communications | 2018 | 12,905 |
47 | Testing for a unit root in time series regression | Biometrika | 1988 | 12,870 |
48 | Positional cloning of the mouse obese gene and its human homologue | Nature | 1994 | 12,326 |
49 | Experimental observation of the quantum Hall effect and Berry's phase in graphene | Nature | 2005 | 12,325 |
50 | [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent | Methods in Enzymology | 1999 | 12,141 |
51 | Resilience and Stability of Ecological Systems | Annual Review of Ecology, Evolution, and Systematics | 1973 | 12,111 |
52 | Comparative Protein Modelling by Satisfaction of Spatial Restraints | Journal of Molecular Biology | 1993 | 12,085 |
53 | Photoelectrochemical cells | Nature | 2001 | 12,077 |
54 | Array programming with NumPy | Nature | 2020 | 12,073 |
55 | TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions | Genome Biology | 2013 | 12,012 |
56 | Graphene-based composite materials | Nature | 2006 | 11,838 |
57 | Predicting transmembrane protein topology with a hidden markov model: application to complete genomes11Edited by F. Cohen | Journal of Molecular Biology | 2001 | 11,677 |
58 | A procedure for the isolation of deoxyribonucleic acid from micro-organisms | Journal of Molecular Biology | 1961 | 11,549 |
59 | Basic Local Alignment Search Tool | Journal of Molecular Biology | 1990 | 11,522 |
60 | Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid | Nature | 1953 | 11,441 |
61 | Monte Carlo sampling methods using Markov chains and their applications | Biometrika | 1970 | 11,436 |
62 | The plant immune system | Nature | 2006 | 11,343 |
63 | The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine | Nature | 1980 | 11,157 |
64 | Learning the parts of objects by non-negative matrix factorization | Nature | 1999 | 11,071 |
65 | Light-emitting diodes based on conjugated polymers | Nature | 1990 | 11,066 |
66 | In situ click chemistry generation of cyclooxygenase-2 inhibitors | Nature Communications | 2017 | 11,016 |
67 | Studies on transformation of Escherichia coli with plasmids | Journal of Molecular Biology | 1983 | 10,933 |
68 | A synaptic model of memory: long-term potentiation in the hippocampus | Nature | 1993 | 10,840 |
69 | Surface plasmon subwavelength optics | Nature | 2003 | 10,726 |
70 | A novel potent vasoconstrictor peptide produced by vascular endothelial cells | Nature | 1988 | 10,683 |
71 | Comprehensive molecular portraits of human breast tumours | Nature | 2012 | 10,601 |
72 | An obesity-associated gut microbiome with increased capacity for energy harvest | Nature | 2006 | 10,430 |
73 | Stages of embryonic development of the zebrafish | Developmental Dynamics | 1995 | 10,376 |
74 | Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor | Nature | 1987 | 10,308 |
75 | Mastering the game of Go with deep neural networks and tree search | Nature | 2016 | 10,303 |
76 | The pathogenesis of atherosclerosis: a perspective for the 1990s | Nature | 1993 | 10,228 |
77 | [30] Microsomal lipid peroxidation | Methods in Enzymology | 1978 | 10,154 |
78 | Structure, function and diversity of the healthy human microbiome | Nature | 2012 | 9,995 |
79 | The functions of animal microRNAs | Nature | 2004 | 9,989 |
80 | A new coronavirus associated with human respiratory disease in China | Nature | 2020 | 9,839 |
81 | A general method applicable to the search for similarities in the amino acid sequence of two proteins | Journal of Molecular Biology | 1970 | 9,781 |
82 | Large-scale pattern growth of graphene films for stretchable transparent electrodes | Nature | 2009 | 9,755 |
83 | Measurement of Diversity | Nature | 1949 | 9,704 |
84 | The missing memristor found | Nature | 2008 | 9,683 |
85 | A human gut microbial gene catalogue established by metagenomic sequencing | Nature | 2010 | 9,658 |
86 | Cancer-related inflammation | Nature | 2008 | 9,652 |
87 | Mutations of the BRAF gene in human cancer | Nature | 2002 | 9,550 |
88 | Antioxidant Determinations by the Use of a Stable Free Radical | Nature | 1958 | 9,444 |
89 | [34] Chlorophylls and carotenoids: Pigments of photosynthetic biomembranes | Methods in Enzymology | 1987 | 9,375 |
90 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,271 |
91 | Opportunities and challenges for a sustainable energy future | Nature | 2012 | 9,089 |
92 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 9,069 |
93 | A safe operating space for humanity | Nature | 2009 | 9,057 |
94 | Sequence and organization of the human mitochondrial genome | Nature | 1981 | 9,054 |
95 | Functional rafts in cell membranes | Nature | 1997 | 9,038 |
96 | MicroRNA expression profiles classify human cancers | Nature | 2005 | 9,031 |
97 | Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Nature | 2007 | 8,982 |
98 | Metascape provides a biologist-oriented resource for the analysis of systems-level datasets | Nature Communications | 2019 | 8,958 |
99 | In vitro selection of RNA molecules that bind specific ligands | Nature | 1990 | 8,835 |
100 | A globally coherent fingerprint of climate change impacts across natural systems | Nature | 2003 | 8,830 |