| # | Title | Journal | Year | Citations |
|---|
| 1 | BoneJ: Free and extensible bone image analysis in ImageJ | Bone | 2010 | 1,695 |
| 2 | Basic biomechanical measurements of bone: A tutorial | Bone | 1993 | 1,441 |
| 3 | Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study | Bone | 2004 | 1,324 |
| 4 | Characterization of cells with osteogenic potential from human marrow | Bone | 1992 | 1,186 |
| 5 | The molecular understanding of osteoclast differentiation | Bone | 2007 | 1,177 |
| 6 | The worldwide problem of osteoporosis: Insights afforded by epidemiology | Bone | 1995 | 1,160 |
| 7 | A meta-analysis of previous fracture and subsequent fracture risk | Bone | 2004 | 1,052 |
| 8 | Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells, | Bone | 2003 | 1,037 |
| 9 | A reference standard for the description of osteoporosis | Bone | 2008 | 929 |
| 10 | Bisphosphonates: The first 40years | Bone | 2011 | 929 |
| 11 | Epidemiology of fractures in England and Wales | Bone | 2001 | 908 |
| 12 | Osteocytes, mechanosensing and Wnt signaling | Bone | 2008 | 904 |
| 13 | The role of synovitis in osteoarthritis pathogenesis | Bone | 2012 | 868 |
| 14 | Inflammation, fracture and bone repair | Bone | 2016 | 825 |
| 15 | Bisphosphonates: A review of their pharmacokinetic properties | Bone | 1996 | 783 |
| 16 | Osteoporosis: A still increasing prevalence | Bone | 2006 | 763 |
| 17 | Bisphosphonates: from the laboratory to the clinic and back again | Bone | 1999 | 761 |
| 18 | Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro | Bone | 2003 | 751 |
| 19 | Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite | Bone | 2006 | 737 |
| 20 | Three rules for bone adaptation to mechanical stimuli | Bone | 1998 | 735 |
| 21 | Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III | Bone | 2002 | 721 |
| 22 | Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro | Bone | 2008 | 705 |
| 23 | Structural and cellular assessment of bone quality of proximal femur | Bone | 1993 | 704 |
| 24 | Three-dimensional methods for quantification of cancellous bone architecture | Bone | 1997 | 688 |
| 25 | Age-related changes in the collagen network and toughness of bone | Bone | 2002 | 670 |
| 26 | The ability of three-dimensional structural indices to reflect mechanical aspects of trabecular bone | Bone | 1999 | 651 |
| 27 | Epidemiology of hip fractures | Bone | 1996 | 622 |
| 28 | Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions | Bone | 1993 | 605 |
| 29 | FRAX® and its applications to clinical practice | Bone | 2009 | 605 |
| 30 | In vivo measurement of human tibial strains during vigorous activity | Bone | 1996 | 604 |
| 31 | Molecular and cellular mechanisms of the anabolic effect of intermittent PTH | Bone | 2007 | 603 |
| 32 | Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies | Bone | 1992 | 595 |
| 33 | Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance | Bone | 1998 | 582 |
| 34 | The clinical consequences of vertebral compression fracture | Bone | 1992 | 580 |
| 35 | SOST is a target gene for PTH in bone | Bone | 2005 | 579 |
| 36 | Morphometric Analysis of Human Bone Biopsies: A Quantitative Structural Comparison of Histological Sections and Micro-Computed Tomography | Bone | 1998 | 575 |
| 37 | Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells | Bone | 1999 | 575 |
| 38 | Genetic variability in adult bone density among inbred strains of mice | Bone | 1996 | 562 |
| 39 | The biological role of strontium | Bone | 2004 | 560 |
| 40 | Denosumab and bisphosphonates: Different mechanisms of action and effects | Bone | 2011 | 556 |
| 41 | Bone mineralization density distribution in health and disease | Bone | 2008 | 554 |
| 42 | Relationships among body mass, its components, and bone11Published simultaneously at BoneKEy-Osteovision (http://www.bonekey-ibms.org), a Web site sponsored by the International Bone and Mineral Society. | Bone | 2002 | 551 |
| 43 | Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images | Bone | 2002 | 538 |
| 44 | Changes in the Stiffness, Strength, and Toughness of Human Cortical Bone With Age | Bone | 1998 | 536 |
| 45 | Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women | Bone | 2000 | 530 |
| 46 | Osteoblast and chondroblast differentiation | Bone | 1995 | 520 |
| 47 | Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration | Bone | 2004 | 520 |
| 48 | Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis | Bone | 2006 | 517 |
| 49 | Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model | Bone | 2008 | 514 |
| 50 | Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly | Bone | 2010 | 510 |
| 51 | Increased intracortical remodeling following fatigue damage | Bone | 1993 | 508 |
| 52 | Incorporation and distribution of strontium in bone | Bone | 2001 | 503 |
| 53 | Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis | Bone | 2007 | 502 |
| 54 | Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: A randomized blinded phase 2 clinical trial | Bone | 2008 | 495 |
| 55 | Trabecular bone pattern factor—a new parameter for simple quantification of bone microarchitecture | Bone | 1992 | 493 |
| 56 | Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography | Bone | 2003 | 486 |
| 57 | Severity of prevalent vertebral fractures and the risk of subsequent vertebral and nonvertebral fractures: results from the MORE trial | Bone | 2003 | 477 |
| 58 | Aging and matrix microdamage accumulation in human compact bone | Bone | 1995 | 476 |
| 59 | Osteoinduction of bone grafting materials for bone repair and regeneration | Bone | 2015 | 469 |
| 60 | The components of excess mortality after hip fracture | Bone | 2003 | 462 |
| 61 | Influence of nonenzymatic glycation on biomechanical properties of cortical bone | Bone | 2001 | 451 |
| 62 | Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals | Bone | 1987 | 449 |
| 63 | The strength of a calcified tissue depends in part on the molecular structure and organization of its constituent mineral crystals in their organic matrix | Bone | 1995 | 448 |
| 64 | The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro | Bone | 1996 | 443 |
| 65 | Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biomechanical properties in clinically relevant skeletal sites in beagles | Bone | 2001 | 437 |
| 66 | Adiponectin and its receptors are expressed in bone-forming cells | Bone | 2004 | 429 |
| 67 | Biochemical and molecular mechanisms of action of bisphosphonates | Bone | 2011 | 426 |
| 68 | Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism | Bone | 2003 | 421 |
| 69 | Changes in trabecular bone, hematopoiesis and bone marrow vessels in aplastic anemia, primary osteoporosis, and old age: A comparative histomorphometric study | Bone | 1987 | 416 |
| 70 | Silk implants for the healing of critical size bone defects | Bone | 2005 | 416 |
| 71 | The function of adipocytes in the bone marrow stroma: an update | Bone | 1996 | 415 |
| 72 | Weight-bearing exercise and bone mineral accrual in children and adolescents: A review of controlled trials | Bone | 2007 | 414 |
| 73 | Macrophages in bone fracture healing: Their essential role in endochondral ossification | Bone | 2018 | 413 |
| 74 | Exercise-induced bone gain is due to enlargement in bone size without a change in volumetric bone density: a peripheral quantitative computed tomography study of the upper arms of male tennis players | Bone | 2000 | 412 |
| 75 | Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin | Bone | 1998 | 411 |
| 76 | The roles of vascular endothelial growth factor in bone repair and regeneration | Bone | 2016 | 411 |
| 77 | New insights into the biology of osteocalcin | Bone | 2016 | 409 |
| 78 | Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies | Bone | 1998 | 401 |
| 79 | Bone development | Bone | 2015 | 401 |
| 80 | Intracortical remodeling in adult rat long bones after fatigue loading | Bone | 1998 | 398 |
| 81 | Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia | Bone | 2006 | 398 |
| 82 | Reproducibility of direct quantitative measures of cortical bone microarchitecture of the distal radius and tibia by HR-pQCT | Bone | 2010 | 397 |
| 83 | Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading | Bone | 2012 | 396 |
| 84 | Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts | Bone | 2002 | 390 |
| 85 | Mechanosensation and transduction in osteocytes | Bone | 2013 | 390 |
| 86 | Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method | Bone | 2008 | 387 |
| 87 | Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression | Bone | 2002 | 384 |
| 88 | Effects of biomechanical stress on bones in animals | Bone | 2002 | 384 |
| 89 | Age-related changes in physicochemical properties of mineral crystals are related to impaired mechanical function of cortical bone | Bone | 2004 | 383 |
| 90 | Hip fractures: A worldwide problem today and tomorrow | Bone | 1993 | 382 |
| 91 | Bone mineral density in female athletes representing sports with different loading characteristics of the skeleton | Bone | 1995 | 382 |
| 92 | Involvement of receptor activator of NFκB ligand and tumor necrosis factor-α in bone destruction in rheumatoid arthritis | Bone | 2002 | 381 |
| 93 | Growth factors for bone growth and repair: IGF, TGFβ and BMP | Bone | 1996 | 378 |
| 94 | Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor | Bone | 1999 | 377 |
| 95 | Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells | Bone | 2004 | 376 |
| 96 | Discontinuation of Denosumab therapy for osteoporosis: A systematic review and position statement by ECTS | Bone | 2017 | 373 |
| 97 | Stronger back muscles reduce the incidence of vertebral fractures: a prospective 10 year follow-up of postmenopausal women | Bone | 2002 | 370 |
| 98 | The effect of aging and ovariectomy on the vertebral bone mass and biomechanical properties of mature rats | Bone | 1993 | 368 |
| 99 | Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone | Bone | 1996 | 368 |
| 100 | Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice | Bone | 2015 | 362 |
