Medicinal Chemistry

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Top Articles

#	Title	Journal	Year	Citations
1	Metals, Toxicity and Oxidative Stress	Current Medicinal Chemistry	2005	3,932
2	The role of antioxidants in the chemistry of oxidative stress: A review	European Journal of Medicinal Chemistry	2015	1,771
3	Toxic Metals and Oxidative Stress Part I: Mechanisms Involved in Me-tal induced Oxidative Damage	Current Topics in Medicinal Chemistry	2001	1,573
4	Antibacterial and Antifungal Properties of Essential Oils	Current Medicinal Chemistry	2003	1,389
5	Therapeutic peptides: Historical perspectives, current development trends, and future directions	Bioorganic and Medicinal Chemistry	2018	1,298
6	Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry	Current Topics in Medicinal Chemistry	2016	1,269
7	Biologically active dihydropyrimidones of the Biginelli-type — a literature survey	European Journal of Medicinal Chemistry	2000	1,249
8	Doxorubicin: The Good, the Bad and the Ugly Effect	Current Medicinal Chemistry	2009	1,042
9	“Multi-component Reactions : Emerging Chemistry in Drug Discovery” ‘From Xylocain to Crixivan’	Current Medicinal Chemistry	2003	985
10	High throughput artificial membrane permeability assay for blood–brain barrier	European Journal of Medicinal Chemistry	2003	972
11	A Review on the Dietary Flavonoid Kaempferol	Mini-Reviews in Medicinal Chemistry	2011	937
12	Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes	Current Medicinal Chemistry	2007	930
13	A review of anti-infective and anti-inflammatory chalcones	European Journal of Medicinal Chemistry	2007	917
14	Natural products in crop protection	Bioorganic and Medicinal Chemistry	2009	909
15	Chemical and Physical Properties and Potential Mechanisms: Melatonin as a Broad Spectrum Antioxidant and Free Radical Scavenger	Current Topics in Medicinal Chemistry	2002	885
16	Molecular recognition of DNA by small molecules	Bioorganic and Medicinal Chemistry	2001	872
17	Microglial Activation and its Implications in the Brain Diseases	Current Medicinal Chemistry	2007	854
18	Subunit Composition, Distribution and Function of GABA-A Receptor Subtypes	Current Topics in Medicinal Chemistry	2002	832
19	Medicinal Chemistry and the Molecular Operating Environment (MOE): Application of QSAR and Molecular Docking to Drug Discovery	Current Topics in Medicinal Chemistry	2008	831
20	Distribution and Biological Activities of the Flavonoid Luteolin	Mini-Reviews in Medicinal Chemistry	2009	829
21	Simple Coumarins and Analogues in Medicinal Chemistry: Occurrence, Synthesis and Biological Activity	Current Medicinal Chemistry	2005	828
22	Carbonic anhydrase inhibitors	Bioorganic and Medicinal Chemistry	1999	808
23	5-Substituted-1H-tetrazoles as carboxylic acid isosteres: medicinal chemistry and synthetic methods	Bioorganic and Medicinal Chemistry	2002	794
24	Fullerene derivatives: an attractive tool for biological applications	European Journal of Medicinal Chemistry	2003	780
25	Immunomodulation and Anti-Cancer Activity of Polysaccharide-Protein Complexes	Current Medicinal Chemistry	2000	749
26	Nanoparticles in cellular drug delivery	Bioorganic and Medicinal Chemistry	2009	744
27	Structure-Based Virtual Screening for Drug Discovery: Principles, Applications and Recent Advances	Current Topics in Medicinal Chemistry	2014	706
28	Development of Nanoparticles for Antimicrobial Drug Delivery	Current Medicinal Chemistry	2010	691
29	Flavonoid Antioxidants	Current Medicinal Chemistry	2001	689
30	Natural products: An evolving role in future drug discovery	European Journal of Medicinal Chemistry	2011	681
31	Structural Bioinformatics and its Impact to Biomedical Science	Current Medicinal Chemistry	2004	674
32	Surface Chemistry Influences Implant Biocompatibility	Current Topics in Medicinal Chemistry	2008	671
33	Copper Complexes as Anticancer Agents	Anti-Cancer Agents in Medicinal Chemistry	2009	661
34	Update of the Preclinical Situation of Anticancer Platinum Complexes: Novel Design Strategies and Innovative Analytical Approaches	Current Medicinal Chemistry	2005	657
35	Spirooxindoles: Promising scaffolds for anticancer agents	European Journal of Medicinal Chemistry	2015	653
36	Anticancer and Antiviral Sulfonamides	Current Medicinal Chemistry	2003	646
37	Oxidative Stress and Cell Signalling	Current Medicinal Chemistry	2004	644
38	A review on recent developments of indole-containing antiviral agents	European Journal of Medicinal Chemistry	2015	643
39	The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes	Mini-Reviews in Medicinal Chemistry	2004	642
40	Biological applications of fullerenes	Bioorganic and Medicinal Chemistry	1996	638
41	The therapeutic journey of benzimidazoles: A review	Bioorganic and Medicinal Chemistry	2012	637
42	3D-QSAR in Drug Design - A Review	Current Topics in Medicinal Chemistry	2010	628
43	Matrix metalloproteinases (MMPs): Chemical–biological functions and (Q)SARs	Bioorganic and Medicinal Chemistry	2007	627
44	Synthesis and pharmacological activity of 2-oxo-(2H) 1-benzopyran-3-carboxamide derivatives	European Journal of Medicinal Chemistry	1993	625
45	Quinolines and structurally related heterocycles as antimalarials	European Journal of Medicinal Chemistry	2010	608
46	Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin	Anti-Cancer Agents in Medicinal Chemistry	2012	597
47	A review on anticancer potential of bioactive heterocycle quinoline	European Journal of Medicinal Chemistry	2015	595
48	β-Carboline Alkaloids: Biochemical and Pharmacological Functions	Current Medicinal Chemistry	2007	594
49	The Catharanthus Alkaloids:Pharmacognosy and Biotechnology	Current Medicinal Chemistry	2004	587
50	Cyclooxygenase inhibitors – current status and future prospects	European Journal of Medicinal Chemistry	2001	581
51	Natural Products as α-Amylase and α-Glucosidase Inhibitors and their Hypoglycaemic Potential in the Treatment of Diabetes: An Update	Mini-Reviews in Medicinal Chemistry	2010	580
52	Chemistry and Biochemistry of Oxidative Stress in Neurodegenerative Disease	Current Medicinal Chemistry	2001	573
53	Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design	Current Medicinal Chemistry	2005	563
54	Copper as a Biocidal Tool	Current Medicinal Chemistry	2005	561
55	Converting a Peptide into a Drug: Strategies to Improve Stability and Bioavailability	Current Medicinal Chemistry	2002	555
56	Recent developments in biological activities of chalcones: A mini review	European Journal of Medicinal Chemistry	2014	555
57	Physicochemical Profiling (Solubility, Permeability and Charge State)	Current Topics in Medicinal Chemistry	2001	547
58	Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation	Anti-Cancer Agents in Medicinal Chemistry	2010	539
59	Ziconotide: Neuronal Calcium Channel Blocker for Treating Severe Chronic Pain	Current Medicinal Chemistry	2004	532
60	The biology and chemistry of antifungal agents: A review	Bioorganic and Medicinal Chemistry	2012	530
61	Biochemical Mechanisms of Cisplatin Cytotoxicity	Anti-Cancer Agents in Medicinal Chemistry	2007	527
62	Chalcones: An Update on Cytotoxic and Chemoprotective Properties	Current Medicinal Chemistry	2005	525
63	Carbonic anhydrases as targets for medicinal chemistry	Bioorganic and Medicinal Chemistry	2007	521
64	Virtual Screening Strategies in Drug Discovery: A Critical Review	Current Medicinal Chemistry	2013	511
65	Bioactivities of Chalcones	Current Medicinal Chemistry	1999	500
66	Antioxidants in Wild Mushrooms	Current Medicinal Chemistry	2009	498
67	From Nature to Drug Discovery: The Indole Scaffold as a ‘Privileged Structure’	Mini-Reviews in Medicinal Chemistry	2009	498
68	The Application of Multi-Component Reactions in Drug Discovery	Current Medicinal Chemistry	2002	495
69	1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview	Bioorganic and Medicinal Chemistry	2019	489
70	Quinoline as a Privileged Scaffold in Cancer Drug Discovery	Current Medicinal Chemistry	2011	488
71	Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease	Current Medicinal Chemistry	2008	484
72	Ruthenium Complexes as Anticancer Agents	Current Medicinal Chemistry	2006	482
73	Biological Properties of Citrus Flavonoids Pertaining to Cancer and Inflammation	Current Medicinal Chemistry	2001	481
74	Peptide Nucleic Acids (PNA): Synthesis, properties and potential applications	Bioorganic and Medicinal Chemistry	1996	476
75	Recent advances in tumor-targeting anticancer drug conjugates	Bioorganic and Medicinal Chemistry	2005	474
76	Silybin and Silymarin - New and Emerging Applications in Medicine	Current Medicinal Chemistry	2007	472
77	New and selective ryanodine receptor activators for insect control	Bioorganic and Medicinal Chemistry	2009	471
78	Pyrazole containing natural products: Synthetic preview and biological significance	European Journal of Medicinal Chemistry	2013	469
79	Recent Researches in Triazole Compounds as Medicinal Drugs	Current Medicinal Chemistry	2012	468
80	Relative Impact of Oxidative Stress on Male Reproductive Function	Current Medicinal Chemistry	2001	467
81	Betulinic Acid and Its Derivatives: A Review on their Biological Properties	Current Medicinal Chemistry	2005	460
82	Multidrug Resistance: Retrospect and Prospects in Anti-Cancer Drug Treatment	Current Medicinal Chemistry	2006	459
83	Glutathione S-Transferases - A Review	Current Medicinal Chemistry	1999	456
84	A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer	Current Medicinal Chemistry	2008	455
85	The Adenine Nucleotide Translocase: A Central Component of the Mitochondrial Permeability Transition Pore and Key Player in Cell Death	Current Medicinal Chemistry	2003	454
86	Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety	Bioorganic and Medicinal Chemistry	2006	454
87	Ruthenium Antimetastatic Agents	Current Topics in Medicinal Chemistry	2004	452
88	PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives	European Journal of Medicinal Chemistry	2016	452
89	Green Tea Catechins and Cardiovascular Health: An Update	Current Medicinal Chemistry	2008	451
90	Exploring Pharmacological Significance of Chalcone Scaffold: A Review	Current Medicinal Chemistry	2012	451
91	Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines	Mini-Reviews in Medicinal Chemistry	2007	446
92	New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies	Bioorganic and Medicinal Chemistry	2006	443
93	Antituberculosis drugs: Ten years of research	Bioorganic and Medicinal Chemistry	2007	441
94	The Significance of Chirality in Drug Design and Development	Current Topics in Medicinal Chemistry	2011	440
95	Role of Oxidative Stress and Molecular Changes in Liver Fibrosis: A Review	Current Medicinal Chemistry	2012	438
96	Criteria for the mode of binding of DNA binding agents	Bioorganic and Medicinal Chemistry	1995	434
97	A review on coumarins as acetylcholinesterase inhibitors for Alzheimer’s disease	Bioorganic and Medicinal Chemistry	2012	434
98	Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition	Bioorganic and Medicinal Chemistry	2010	433
99	Pharmacology of Cannabinoid Receptor Ligands	Current Medicinal Chemistry	1999	431
100	Oxytosis: A Novel Form of Programmed Cell Death	Current Topics in Medicinal Chemistry	2001	428

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