# | Title | Journal | Year | Citations |
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1 | PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT | Journal of Biological Chemistry | 1951 | 284,654 |
2 | Protein measurement with the Folin phenol reagent | Journal of Biological Chemistry | 1951 | 242,821 |
3 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding | Analytical Biochemistry | 1976 | 215,588 |
4 | A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding | Analytical Biochemistry | 1976 | 92,750 |
5 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction | Analytical Biochemistry | 1987 | 58,438 |
6 | A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES | Journal of Biological Chemistry | 1957 | 55,906 |
7 | Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement | PLoS Medicine | 2009 | 50,671 |
8 | The Sequence Alignment/Map format and SAMtools | Bioinformatics | 2009 | 49,124 |
9 | Fiji: an open-source platform for biological-image analysis | Nature Methods | 2012 | 47,818 |
10 | NIH Image to ImageJ: 25 years of image analysis | Nature Methods | 2012 | 46,756 |
11 | Trimmomatic: a flexible trimmer for Illumina sequence data | Bioinformatics | 2014 | 46,646 |
12 | Fast and accurate short read alignment with Burrows–Wheeler transform | Bioinformatics | 2009 | 43,062 |
13 | Fast gapped-read alignment with Bowtie 2 | Nature Methods | 2012 | 42,357 |
14 | Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues | Cellular Physiology and Biochemistry | 2013 | 42,260 |
15 | A simple method for the isolation and purification of total lipides from animal tissues | Journal of Biological Chemistry | 1957 | 41,692 |
16 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 39,151 |
17 | STAR: ultrafast universal RNA-seq aligner | Bioinformatics | 2013 | 35,376 |
18 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data | Bioinformatics | 2010 | 32,955 |
19 | QIIME allows analysis of high-throughput community sequencing data | Nature Methods | 2010 | 31,818 |
20 | Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction | Analytical Biochemistry | 1987 | 27,111 |
21 | Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge | Clinical Chemistry | 1972 | 26,892 |
22 | Preparation of Graphitic Oxide | Journal of the American Chemical Society | 1958 | 26,827 |
23 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies | Bioinformatics | 2014 | 26,744 |
24 | MrBayes 3: Bayesian phylogenetic inference under mixed models | Bioinformatics | 2003 | 26,519 |
25 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 25,451 |
26 | Clustal W and Clustal X version 2.0 | Bioinformatics | 2007 | 25,174 |
27 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity | Analytical Biochemistry | 1983 | 24,572 |
28 | Adsorption of Gases in Multimolecular Layers | Journal of the American Chemical Society | 1938 | 23,496 |
29 | A new and rapid colorimetric determination of acetylcholinesterase activity | Biochemical Pharmacology | 1961 | 23,305 |
30 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Biochemistry | 1979 | 23,186 |
31 | Tissue sulfhydryl groups | Archives of Biochemistry and Biophysics | 1959 | 23,177 |
32 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction | Analytical Biochemistry | 1979 | 22,890 |
33 | clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters | OMICS A Journal of Integrative Biology | 2012 | 21,237 |
34 | BEDTools: a flexible suite of utilities for comparing genomic features | Bioinformatics | 2010 | 20,367 |
35 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | Journal of Biological Chemistry | 1985 | 20,165 |
36 | MRBAYES: Bayesian inference of phylogenetic trees | Bioinformatics | 2001 | 20,154 |
37 | Measurement of protein using bicinchoninic acid | Analytical Biochemistry | 1985 | 19,774 |
38 | The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis | Journal of Biological Chemistry | 1969 | 19,178 |
39 | SHELXT– Integrated space-group and crystal-structure determination | Acta Crystallographica Section A: Foundations and Advances | 2015 | 18,933 |
40 | MODELTEST: testing the model of DNA substitution | Bioinformatics | 1998 | 18,761 |
41 | DADA2: High-resolution sample inference from Illumina amplicon data | Nature Methods | 2016 | 18,691 |
42 | Search and clustering orders of magnitude faster than BLAST | Bioinformatics | 2010 | 18,572 |
43 | THE ADSORPTION OF GASES ON PLANE SURFACES OF GLASS, MICA AND PLATINUM. | Journal of the American Chemical Society | 1918 | 18,014 |
44 | Antioxidant activity applying an improved ABTS radical cation decolorization assay | Free Radical Biology and Medicine | 1999 | 17,909 |
45 | Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic Cells | Journal of the American Chemical Society | 2009 | 17,777 |
46 | High resolution two-dimensional electrophoresis of proteins. | Journal of Biological Chemistry | 1975 | 17,755 |
47 | THE COLORIMETRIC DETERMINATION OF PHOSPHORUS | Journal of Biological Chemistry | 1925 | 17,551 |
48 | SciPy 1.0: fundamental algorithms for scientific computing in Python | Nature Methods | 2020 | 17,539 |
49 | WGCNA: an R package for weighted correlation network analysis | BMC Bioinformatics | 2008 | 17,294 |
50 | HTSeq—a Python framework to work with high-throughput sequencing data | Bioinformatics | 2015 | 17,270 |
51 | Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches | Pflugers Archiv European Journal of Physiology | 1981 | 17,126 |
52 | A modified single solution method for the determination of phosphate in natural waters | Analytica Chimica Acta | 1962 | 16,980 |
53 | featureCounts: an efficient general purpose program for assigning sequence reads to genomic features | Bioinformatics | 2014 | 16,839 |
54 | A new generation of Ca2+ indicators with greatly improved fluorescence properties | Journal of Biological Chemistry | 1985 | 16,813 |
55 | The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis | Journal of Biological Chemistry | 1969 | 16,592 |
56 | HISAT: a fast spliced aligner with low memory requirements | Nature Methods | 2015 | 16,262 |
57 | Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence data | Bioinformatics | 2012 | 16,096 |
58 | RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome | BMC Bioinformatics | 2011 | 16,042 |
59 | The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP Assay | Analytical Biochemistry | 1996 | 16,000 |
60 | High resolution two-dimensional electrophoresis of proteins | Journal of Biological Chemistry | 1975 | 15,403 |
61 | BLAST+: architecture and applications | BMC Bioinformatics | 2009 | 14,935 |
62 | RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models | Bioinformatics | 2006 | 14,675 |
63 | Glutathione S-Transferases | Journal of Biological Chemistry | 1974 | 14,618 |
64 | NMRPipe: A multidimensional spectral processing system based on UNIX pipes | Journal of Biomolecular NMR | 1995 | 14,090 |
65 | DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION | Journal of Biological Chemistry | 1949 | 14,083 |
66 | Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features | Biopolymers | 1983 | 13,990 |
67 | Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. | Journal of Histochemistry and Cytochemistry | 1981 | 13,859 |
68 | The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration | PLoS Medicine | 2009 | 13,772 |
69 | DnaSP v5: a software for comprehensive analysis of DNA polymorphism data | Bioinformatics | 2009 | 13,645 |
70 | jModelTest 2: more models, new heuristics and parallel computing | Nature Methods | 2012 | 13,416 |
71 | Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular model | Journal of the American Chemical Society | 1985 | 13,340 |
72 | UCHIME improves sensitivity and speed of chimera detection | Bioinformatics | 2011 | 13,241 |
73 | Pseudo-second order model for sorption processes | Process Biochemistry | 1999 | 13,223 |
74 | Haploview: analysis and visualization of LD and haplotype maps | Bioinformatics | 2005 | 13,223 |
75 | UPARSE: highly accurate OTU sequences from microbial amplicon reads | Nature Methods | 2013 | 13,193 |
76 | Prokka: rapid prokaryotic genome annotation | Bioinformatics | 2014 | 12,881 |
77 | Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction | Biochemical Pharmacology | 1973 | 12,583 |
78 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments | Clinical Chemistry | 2009 | 12,487 |
79 | Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic Liquids | Journal of the American Chemical Society | 1996 | 12,123 |
80 | A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules | Journal of the American Chemical Society | 1995 | 12,116 |
81 | Phosphorus Assay in Column Chromatography | Journal of Biological Chemistry | 1959 | 12,077 |
82 | Mapping and quantifying mammalian transcriptomes by RNA-Seq | Nature Methods | 2008 | 12,050 |
83 | Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa | Analytical Biochemistry | 1987 | 11,692 |
84 | The Determination of Enzyme Dissociation Constants | Journal of the American Chemical Society | 1934 | 11,587 |
85 | FLASH: fast length adjustment of short reads to improve genome assemblies | Bioinformatics | 2011 | 11,573 |
86 | A method and server for predicting damaging missense mutations | Nature Methods | 2010 | 11,491 |
87 | The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen Isotherms | Journal of the American Chemical Society | 1951 | 11,369 |
88 | Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal | Science Signaling | 2013 | 11,344 |
89 | The variant call format and VCFtools | Bioinformatics | 2011 | 11,326 |
90 | TopHat: discovering splice junctions with RNA-Seq | Bioinformatics | 2009 | 11,265 |
91 | Repertoires of Autophagy in the Pathogenesis of Ocular Diseases | Cellular Physiology and Biochemistry | 2015 | 11,181 |
92 | Calcium's Role in Mechanotransduction during Muscle Development | Cellular Physiology and Biochemistry | 2014 | 11,109 |
93 | fastp: an ultra-fast all-in-one FASTQ preprocessor | Bioinformatics | 2018 | 11,005 |
94 | Superoxide Dismutase | Journal of Biological Chemistry | 1969 | 10,959 |
95 | Glutathione S-transferases. The first enzymatic step in mercapturic acid formation | Journal of Biological Chemistry | 1974 | 10,908 |
96 | Free radicals and antioxidants in normal physiological functions and human disease | International Journal of Biochemistry and Cell Biology | 2007 | 10,891 |
97 | Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids | Analytical Biochemistry | 1982 | 10,819 |
98 | GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research—an update | Bioinformatics | 2012 | 10,741 |
99 | APE: Analyses of Phylogenetics and Evolution in R language | Bioinformatics | 2004 | 10,601 |
100 | Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research | Bioinformatics | 2005 | 10,566 |