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Top Articles

#TitleJournalYearCitations
1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry1951284,654
2Protein measurement with the Folin phenol reagentJournal of Biological Chemistry1951242,821
3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry1976215,588
4Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods2001145,087
5A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry197692,750
6Basic local alignment search toolJournal of Molecular Biology199082,180
7A short history ofSHELXActa Crystallographica Section A: Foundations and Advances200881,966
8“Mini-mental state”Journal of Psychiatric Research197577,621
9Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research199764,420
10CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research199459,168
11Long Short-Term MemoryNeural Computation199758,553
12Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry198758,438
13Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Genome Biology201458,325
14A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue CulturesPhysiologia Plantarum196256,749
15A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry195755,906
16The Measurement of Observer Agreement for Categorical DataBiometrics197755,540
17Hallmarks of Cancer: The Next GenerationCell201152,242
18Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine200950,671
19The Sequence Alignment/Map format and SAMtoolsBioinformatics200949,124
20The neighbor-joining method: a new method for reconstructing phylogenetic trees.Molecular Biology and Evolution198749,040
21Fiji: an open-source platform for biological-image analysisNature Methods201247,818
22Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJournal of Immunological Methods198347,133
23VMD: Visual molecular dynamicsJournal of Molecular Graphics199646,937
24NIH Image to ImageJ: 25 years of image analysisNature Methods201246,756
25Trimmomatic: a flexible trimmer for Illumina sequence dataBioinformatics201446,646
26Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics200943,062
27Fast gapped-read alignment with Bowtie 2Nature Methods201242,357
28Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice TissuesCellular Physiology and Biochemistry201342,260
29A simple method for the isolation and purification of total lipides from animal tissuesJournal of Biological Chemistry195741,692
30A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195939,151
31G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciencesBehavior Research Methods200738,307
32MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0Molecular Biology and Evolution201337,728
33Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research200337,062
34MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research200436,947
35MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger DatasetsMolecular Biology and Evolution201636,708
36MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony MethodsMolecular Biology and Evolution201136,550
37Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology197535,546
38STAR: ultrafast universal RNA-seq alignerBioinformatics201335,376
39CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAPEvolution; International Journal of Organic Evolution198535,356
40Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.EMBO Journal199635,118
41The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsNucleic Acids Research199734,934
42Gene Ontology: tool for the unification of biologyNature Genetics200034,499
43Meta-analysis in clinical trialsContemporary Clinical Trials198633,020
44edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataBioinformatics201032,955
45MicroRNAsCell200432,446
46The assessment and analysis of handedness: The Edinburgh inventoryNeuropsychologia197132,207
47MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and UsabilityMolecular Biology and Evolution201332,012
48Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesNature Protocols200931,831
49QIIME allows analysis of high-throughput community sequencing dataNature Methods201031,818
50The Protein Data BankNucleic Acids Research200031,087
51[20] Processing of X-ray diffraction data collected in oscillation modeMethods in Enzymology199730,205
52A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research200128,594
53Inference of Population Structure Using Multilocus Genotype DataGenetics200028,015
54Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry198727,111
55Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative UltracentrifugeClinical Chemistry197226,892
56Quantifying heterogeneity in a meta-analysisStatistics in Medicine200226,845
57Preparation of Graphitic OxideJournal of the American Chemical Society195826,827
58PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics200726,761
59RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogeniesBioinformatics201426,744
60Coot: model-building tools for molecular graphicsActa Crystallographica Section D: Biological Crystallography200426,736
61MrBayes 3: Bayesian phylogenetic inference under mixed modelsBioinformatics200326,519
62limma powers differential expression analyses for RNA-sequencing and microarray studiesNucleic Acids Research201526,032
63MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0Molecular Biology and Evolution200725,988
64A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution198025,715
65MEGA X: Molecular Evolutionary Genetics Analysis across Computing PlatformsMolecular Biology and Evolution201825,630
66A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195925,451
67KEGG: Kyoto Encyclopedia of Genes and GenomesNucleic Acids Research200025,375
68Clustal W and Clustal X version 2.0Bioinformatics200725,174
69The Hallmarks of CancerCell200024,832
70THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPYJournal of Cell Biology196324,709
71A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry198324,572
72Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012International Journal of Cancer201523,615
73Adsorption of Gases in Multimolecular LayersJournal of the American Chemical Society193823,496
74A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology196123,305
75The Pittsburgh sleep quality index: A new instrument for psychiatric practice and researchPsychiatry Research198923,254
76Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator modelsBehavior Research Methods200823,188
77Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry197923,186
78Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics195923,177
79Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry197922,890
80Features and development of CootActa Crystallographica Section D: Biological Crystallography201022,799
81Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell200622,649
82A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology198222,171
83OLEX2: a complete structure solution, refinement and analysis programJournal of Applied Crystallography200921,944
84New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)European Journal of Cancer200921,739
85The central role of the propensity score in observational studies for causal effectsBiometrika198321,591
86The SILVA ribosomal RNA gene database project: improved data processing and web-based toolsNucleic Acids Research201221,425
87The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing dataGenome Research201021,358
88clusterProfiler: an R Package for Comparing Biological Themes Among Gene ClustersOMICS A Journal of Integrative Biology201221,237
89PROCHECK: a program to check the stereochemical quality of protein structuresJournal of Applied Crystallography199321,188
90Analyzing real-time PCR data by the comparative CT methodNature Protocols200821,086
91PHENIX: a comprehensive Python-based system for macromolecular structure solutionActa Crystallographica Section D: Biological Crystallography201020,564
92MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model SpaceSystematic Biology201220,458
93Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular PathologyGenetics in Medicine201520,455
94THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences194920,417
95BEDTools: a flexible suite of utilities for comparing genomic featuresBioinformatics201020,367
96SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell SequencingJournal of Computational Biology201220,193
97A new generation of Ca2+ indicators with greatly improved fluorescence properties.Journal of Biological Chemistry198520,165
98MRBAYES: Bayesian inference of phylogenetic treesBioinformatics200120,154
99Methods for Dietary Fiber, Neutral Detergent Fiber, and Nonstarch Polysaccharides in Relation to Animal NutritionJournal of Dairy Science199120,119
100The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errorsMolecular Physics197020,046