| Gene ontology: tool for the unification of biology. The Gene Ontology Consortium | Nature Genetics | 2000 | 25.6K |
| The Protein Data Bank | Nucleic Acids Research | 2000 | 24.1K |
| Inference of population structure using multilocus genotype data | Genetics | 2000 | 22.3K |
| KEGG: kyoto encyclopedia of genes and genomes | Nucleic Acids Research | 2000 | 15.7K |
| Primer3 on the WWW for general users and for biologist programmers | Methods in Molecular Biology | 2000 | 8.6K |
| TCS: a computer program to estimate gene genealogies | Molecular Ecology | 2000 | 7.6K |
| Selection of conserved blocks from multiple alignments for their use in phylogenetic analysis | Molecular Biology and Evolution | 2000 | 6.9K |
| EMBOSS: the European Molecular Biology Open Software Suite | Trends in Genetics | 2000 | 6.4K |
| Loop-mediated isothermal amplification of DNA | Nucleic Acids Research | 2000 | 5.1K |
| Single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing | Environmental and Molecular Mutagenesis | 2000 | 3.5K |
| A greedy algorithm for aligning DNA sequences | Journal of Computational Biology | 2000 | 3.2K |
| Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells | Nature Genetics | 2000 | 2.9K |
| The COG database: a tool for genome-scale analysis of protein functions and evolution | Nucleic Acids Research | 2000 | 2.7K |
| Oxidative stress and some antioxidant systems in acid rain-treated bean plants: Protective role of exogenous polyamines | Plant Science | 2000 | 2.3K |
| Effective targeted gene 'knockdown' in zebrafish | Nature Genetics | 2000 | 2.1K |
| Wnt signaling and cancer | Genes and Development | 2000 | 2.1K |
| Gaps as Characters in Sequence-Based Phylogenetic Analyses | Systematic Biology | 2000 | 2.1K |
| Using Bayesian networks to analyze expression data | Journal of Computational Biology | 2000 | 2K |
| The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000 | Nucleic Acids Research | 2000 | 1.9K |
| STATs in oncogenesis | Oncogene | 2000 | 1.7K |
| Codon-substitution models for heterogeneous selection pressure at amino acid sites | Genetics | 2000 | 1.7K |
| Systematic variation in gene expression patterns in human cancer cell lines | Nature Genetics | 2000 | 1.7K |
| TLR4 mutations are associated with endotoxin hyporesponsiveness in humans | Nature Genetics | 2000 | 1.7K |
| Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase | Nature Genetics | 2000 | 1.7K |
| The in vitro micronucleus technique | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis | 2000 | 1.7K |
