| # | Title | Journal | Year | Citations |
|---|
| 1 | A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability | Pharmaceutical Research | 1995 | 4,287 |
| 2 | Methods for in vitro evaluating antimicrobial activity: A review | Journal of Pharmaceutical Analysis | 2016 | 3,675 |
| 3 | Physiological parameters in laboratory animals and humans | Pharmaceutical Research | 1993 | 2,505 |
| 4 | Segmented regression analysis of interrupted time series studies in medication use research | Journal of Clinical Pharmacy and Therapeutics | 2002 | 2,459 |
| 5 | Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date | Pharmaceutical Research | 2016 | 1,976 |
| 6 | Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods | Acta Pharmaceutica Sinica B | 2020 | 1,704 |
| 7 | Cancer is a Preventable Disease that Requires Major Lifestyle Changes | Pharmaceutical Research | 2008 | 1,644 |
| 8 | Clinical practice guidelines for antimicrobial prophylaxis in surgery | American Journal of Health-System Pharmacy | 2013 | 1,643 |
| 9 | Micellar Nanocarriers: Pharmaceutical Perspectives | Pharmaceutical Research | 2006 | 1,586 |
| 10 | Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists | American Journal of Health-System Pharmacy | 2009 | 1,502 |
| 11 | Bioanalytical method validation--a revisit with a decade of progress | Pharmaceutical Research | 2000 | 1,423 |
| 12 | Patient adherence to treatment: three decades of research. A comprehensive review | Journal of Clinical Pharmacy and Therapeutics | 2001 | 1,402 |
| 13 | Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates | Pharmaceutical Research | 2010 | 1,402 |
| 14 | HIF-1α pathway: role, regulation and intervention for cancer therapy | Acta Pharmaceutica Sinica B | 2015 | 1,377 |
| 15 | Pharmaceutical Particle Engineering via Spray Drying | Pharmaceutical Research | 2008 | 1,308 |
| 16 | Predicting skin permeability | Pharmaceutical Research | 1992 | 1,247 |
| 17 | Chitosan and its use as a pharmaceutical excipient | Pharmaceutical Research | 1998 | 1,225 |
| 18 | Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System | Pharmaceutical Research | 2005 | 1,222 |
| 19 | Molecular immune pathogenesis and diagnosis of COVID-19 | Journal of Pharmaceutical Analysis | 2020 | 1,208 |
| 20 | Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation | Pharmaceutical Research | 2003 | 1,179 |
| 21 | Solubilizing Excipients in Oral and Injectable Formulations | Pharmaceutical Research | 2004 | 1,154 |
| 22 | A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity | Pharmaceutical Research | 1999 | 1,128 |
| 23 | Colloidal Gold: A Novel Nanoparticle Vector for Tumor Directed Drug Delivery | Drug Delivery | 2004 | 1,080 |
| 24 | Two new flavonoids and other constituents in licorice root. Their relative astringency and radical scavenging effects. | Chemical and Pharmaceutical Bulletin | 1988 | 1,028 |
| 25 | Extrinsic Fluorescent Dyes as Tools for Protein Characterization | Pharmaceutical Research | 2008 | 1,013 |
| 26 | Cyclodextrins in drug delivery: An updated review | AAPS PharmSciTech | 2005 | 976 |
| 27 | A Review of Poloxamer 407 Pharmaceutical and Pharmacological Characteristics | Pharmaceutical Research | 2006 | 970 |
| 28 | Pharmaceutical Quality by Design: Product and Process Development, Understanding, and Control | Pharmaceutical Research | 2008 | 964 |
| 29 | Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges | Acta Pharmaceutica Sinica B | 2016 | 949 |
| 30 | Opportunities and responsibilities in pharmaceutical care | American Journal of Health-System Pharmacy | 1990 | 939 |
| 31 | Stability of Protein Pharmaceuticals: An Update | Pharmaceutical Research | 2010 | 936 |
| 32 | Insoluble drug delivery strategies: review of recent advances and business prospects | Acta Pharmaceutica Sinica B | 2015 | 931 |
| 33 | Stability of protein pharmaceuticals | Pharmaceutical Research | 1989 | 921 |
| 34 | Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications | Pharmaceutical Research | 2007 | 917 |
| 35 | Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms | Pharmaceutical Research | 1998 | 893 |
| 36 | Ritonavir: an extraordinary example of conformational polymorphism | Pharmaceutical Research | 2001 | 860 |
| 37 | Nanotechnology: Intelligent Design to Treat Complex Disease | Pharmaceutical Research | 2006 | 858 |
| 38 | PEG Hydrogels for the Controlled Release of Biomolecules in Regenerative Medicine | Pharmaceutical Research | 2009 | 846 |
| 39 | Validity and reliability of measurement instruments used in research | American Journal of Health-System Pharmacy | 2008 | 827 |
| 40 | Gastrointestinal uptake of biodegradable microparticles: effect of particle size | Pharmaceutical Research | 1996 | 819 |
| 41 | Cationic polymer based gene delivery systems | Pharmaceutical Research | 2000 | 816 |
| 42 | Evaluation of various dissolution media for predicting in vivo performance of class I and II drugs | Pharmaceutical Research | 1998 | 796 |
| 43 | Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release | Pharmaceutical Research | 2010 | 791 |
| 44 | Center for the Advancement of Pharmacy Education 2013 Educational Outcomes | American Journal of Pharmaceutical Education | 2013 | 790 |
| 45 | Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures | Pharmaceutical Research | 1995 | 788 |
| 46 | Delivering CRISPR: a review of the challenges and approaches | Drug Delivery | 2018 | 776 |
| 47 | Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres | Pharmaceutical Research | 1991 | 774 |
| 48 | Thematic analysis of qualitative research data: Is it as easy as it sounds? | Currents in Pharmacy Teaching and Learning | 2018 | 771 |
| 49 | Practical Aspects of the Ligand-Binding and Enzymatic Properties of Human Serum Albumin. | Biological and Pharmaceutical Bulletin | 2002 | 764 |
| 50 | Exosome Delivered Anticancer Drugs Across the Blood-Brain Barrier for Brain Cancer Therapy in Danio Rerio | Pharmaceutical Research | 2015 | 762 |
| 51 | The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent | Pharmaceutical Research | 1997 | 753 |
| 52 | Design of Freeze-Drying Processes for Pharmaceuticals: Practical Advice | Pharmaceutical Research | 2004 | 745 |
| 53 | Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC | Chemical and Pharmaceutical Bulletin | 2007 | 743 |
| 54 | Apolipoprotein-mediated Transport of Nanoparticle-bound Drugs Across the Blood-Brain Barrier | Journal of Drug Targeting | 2002 | 738 |
| 55 | Role of Particle Size in Phagocytosis of Polymeric Microspheres | Pharmaceutical Research | 2008 | 729 |
| 56 | Methods for the Preparation and Manufacture of Polymeric Nanoparticles | Pharmaceutical Research | 2009 | 729 |
| 57 | Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants | Journal of Pharmaceutical Analysis | 2020 | 721 |
| 58 | Introduction to metallic nanoparticles | Journal of Pharmacy and Bioallied Sciences | 2010 | 706 |
| 59 | Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2) | Pharmaceutical Research | 1994 | 705 |
| 60 | Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation | Pharmaceutical Research | 2004 | 697 |
| 61 | Polar molecular surface as a dominating determinant for oral absorption and brain penetration of drugs | Pharmaceutical Research | 1999 | 696 |
| 62 | Response Rates and Responsiveness for Surveys, Standards, and the Journal | American Journal of Pharmaceutical Education | 2008 | 688 |
| 63 | Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement | Pharmaceutical Research | 2006 | 684 |
| 64 | Quantitative Bioanalytical Methods Validation and Implementation: Best Practices for Chromatographic and Ligand Binding Assays | Pharmaceutical Research | 2007 | 679 |
| 65 | Cancer metastases: challenges and opportunities | Acta Pharmaceutica Sinica B | 2015 | 678 |
| 66 | A Combined Assay of Cell Viability and in Vitro Cytotoxicity with a Highly Water-Soluble Tetrazolium Salt, Neutral Red and Crystal Violet. | Biological and Pharmaceutical Bulletin | 1996 | 677 |
| 67 | Polar molecular surface properties predict the intestinal absorption of drugs in humans | Pharmaceutical Research | 1997 | 668 |
| 68 | Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres | Pharmaceutical Research | 2000 | 659 |
| 69 | Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines | Pharmaceutical Research | 1997 | 648 |
| 70 | Click Chemistry, A Powerful Tool for Pharmaceutical Sciences | Pharmaceutical Research | 2008 | 645 |
| 71 | Apigenin: A Promising Molecule for Cancer Prevention | Pharmaceutical Research | 2010 | 642 |
| 72 | Therapeutic monitoring of vancomycin for serious methicillin-resistantStaphylococcus aureusinfections: A revised consensus guideline and review by the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists | American Journal of Health-System Pharmacy | 2020 | 640 |
| 73 | Protein instability in poly(lactic-co-glycolic acid) microparticles | Pharmaceutical Research | 2000 | 636 |
| 74 | Dissolution Media Simulating Conditions in the Proximal Human Gastrointestinal Tract: An Update | Pharmaceutical Research | 2008 | 633 |
| 75 | Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability | Journal of Drug Targeting | 2004 | 626 |
| 76 | Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery | AAPS PharmSciTech | 2011 | 619 |
| 77 | The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids | Pharmaceutical Research | 1994 | 617 |
| 78 | Upper gastrointestinal (GI) pH in young, healthy men and women | Pharmaceutical Research | 1990 | 613 |
| 79 | Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects | Pharmaceutical Research | 1995 | 613 |
| 80 | Gas-liquid chromatographic separation of aldose enantiomers as trimethylsilyl ethers of methyl 2-(polyhydroxyalkyl)-thiazolidine-4(R)-carboxylates. | Chemical and Pharmaceutical Bulletin | 1987 | 612 |
| 81 | Effects of the interaction of tannins with Co-existing substances. VI. Effects of tannins and related polyphenols on superoxide anion radical, and on 1,1-diphenyl-2-picrylhydrazyl radical. | Chemical and Pharmaceutical Bulletin | 1989 | 610 |
| 82 | An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site | Pharmaceutical Research | 2012 | 610 |
| 83 | Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API | Pharmaceutical Research | 2006 | 604 |
| 84 | Rational design of stable lyophilized protein formulations: some practical advice | Pharmaceutical Research | 1997 | 592 |
| 85 | Chitosan as a novel nasal delivery system for peptide drugs | Pharmaceutical Research | 1994 | 586 |
| 86 | Development of forced degradation and stability indicating studies of drugs—A review | Journal of Pharmaceutical Analysis | 2014 | 586 |
| 87 | Poly(ethylene glycol)-modified Nanocarriers for Tumor-targeted and Intracellular Delivery | Pharmaceutical Research | 2007 | 584 |
| 88 | Design and function of a dendrimer-based therapeutic nanodevice targeted to tumor cells through the folate receptor | Pharmaceutical Research | 2002 | 583 |
| 89 | let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells | Biological and Pharmaceutical Bulletin | 2006 | 583 |
| 90 | Presenting and Evaluating Qualitative Research | American Journal of Pharmaceutical Education | 2010 | 583 |
| 91 | Rate-limited steps of human oral absorption and QSAR studies | Pharmaceutical Research | 2002 | 576 |
| 92 | Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man. | Chemical and Pharmaceutical Bulletin | 1961 | 572 |
| 93 | Lipid-based Nanoparticles for Nucleic Acid Delivery | Pharmaceutical Research | 2007 | 571 |
| 94 | Effects of Particle Size and Surface Modification on Cellular Uptake and Biodistribution of Polymeric Nanoparticles for Drug Delivery | Pharmaceutical Research | 2013 | 571 |
| 95 | Drug-Related Morbidity and Mortality: Updating the Cost-of-Illness Model | Journal of the American Pharmacists Association | 2001 | 567 |
| 96 | Particle Engineering for Pulmonary Drug Delivery | Pharmaceutical Research | 2007 | 560 |
| 97 | Characterization of the Human Upper Gastrointestinal Contents Under Conditions Simulating Bioavailability/Bioequivalence Studies | Pharmaceutical Research | 2006 | 558 |
| 98 | Population Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in Pediatrics | Pharmaceutical Research | 2006 | 554 |
| 99 | Recommendations for the Bioanalytical Method Validation of Ligand-Binding Assays to Support Pharmacokinetic Assessments of Macromolecules | Pharmaceutical Research | 2003 | 551 |
| 100 | Polymer Architecture and Drug Delivery | Pharmaceutical Research | 2006 | 551 |
