| # | Title | Journal | Year | Citations |
|---|
|
| 1 | Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge | Clinical Chemistry | 1972 | 27,273 |
| 2 | The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments | Clinical Chemistry | 2009 | 12,959 |
| 3 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy | Journal of Medicinal Chemistry | 2004 | 7,783 |
| 4 | Enzymatic Determination of Total Serum Cholesterol | Clinical Chemistry | 1974 | 7,756 |
| 5 | Molecular Properties That Influence the Oral Bioavailability of Drug Candidates | Journal of Medicinal Chemistry | 2002 | 5,954 |
| 6 | Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine | Clinical Chemistry | 1993 | 5,653 |
| 7 | Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes | Journal of Medicinal Chemistry | 2006 | 5,468 |
| 8 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Nature Reviews Drug Discovery | 2009 | 4,469 |
| 9 | Recent advances with liposomes as pharmaceutical carriers | Nature Reviews Drug Discovery | 2005 | 4,431 |
| 10 | Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals | Journal of Medicinal Chemistry | 2014 | 4,391 |
| 11 | Modeling and comparison of dissolution profiles | European Journal of Pharmaceutical Sciences | 2001 | 4,227 |
| 12 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening | Journal of Medicinal Chemistry | 2004 | 4,182 |
| 13 | Metals, Toxicity and Oxidative Stress | Current Medicinal Chemistry | 2005 | 4,032 |
| 14 | Engineering precision nanoparticles for drug delivery | Nature Reviews Drug Discovery | 2021 | 3,830 |
| 15 | Nanoparticle therapeutics: an emerging treatment modality for cancer | Nature Reviews Drug Discovery | 2008 | 3,790 |
| 16 | MicroRNA therapeutics: towards a new era for the management of cancer and other diseases | Nature Reviews Drug Discovery | 2017 | 3,706 |
| 17 | Can the pharmaceutical industry reduce attrition rates? | Nature Reviews Drug Discovery | 2004 | 3,568 |
| 18 | A simple method for clinical assay of superoxide dismutase. | Clinical Chemistry | 1988 | 3,366 |
| 19 | Therapeutic potential of resveratrol: the in vivo evidence | Nature Reviews Drug Discovery | 2006 | 3,336 |
| 20 | Modified Reagents for Determination of Urea and Ammonia | Clinical Chemistry | 1962 | 3,290 |
| 21 | Cellular processing of platinum anticancer drugs | Nature Reviews Drug Discovery | 2005 | 3,264 |
| 22 | Strategies in the design of nanoparticles for therapeutic applications | Nature Reviews Drug Discovery | 2010 | 3,195 |
| 23 | Targeting multidrug resistance in cancer | Nature Reviews Drug Discovery | 2006 | 3,145 |
| 24 | How many drug targets are there? | Nature Reviews Drug Discovery | 2006 | 3,131 |
| 25 | New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry | 2010 | 3,111 |
| 26 | The Many Roles for Fluorine in Medicinal Chemistry | Journal of Medicinal Chemistry | 2008 | 3,101 |
| 27 | Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success | Journal of Medicinal Chemistry | 2009 | 3,024 |
| 28 | The dawning era of polymer therapeutics | Nature Reviews Drug Discovery | 2003 | 2,993 |
| 29 | Neurodegenerative diseases and oxidative stress | Nature Reviews Drug Discovery | 2004 | 2,992 |
| 30 | Effect of pegylation on pharmaceuticals | Nature Reviews Drug Discovery | 2003 | 2,989 |
| 31 | The druggable genome | Nature Reviews Drug Discovery | 2002 | 2,964 |
| 32 | Drug repurposing: progress, challenges and recommendations | Nature Reviews Drug Discovery | 2019 | 2,956 |
| 33 | Membrane transporters in drug development | Nature Reviews Drug Discovery | 2010 | 2,952 |
| 34 | mRNA vaccines — a new era in vaccinology | Nature Reviews Drug Discovery | 2018 | 2,921 |
| 35 | Docking and scoring in virtual screening for drug discovery: methods and applications | Nature Reviews Drug Discovery | 2004 | 2,858 |
| 36 | How to improve R&D productivity: the pharmaceutical industry's grand challenge | Nature Reviews Drug Discovery | 2010 | 2,851 |
| 37 | Modulation of oxidative stress as an anticancer strategy | Nature Reviews Drug Discovery | 2013 | 2,847 |
| 38 | Quantitative Determination of Serum Triglycerides by the Use of Enzymes | Clinical Chemistry | 1973 | 2,818 |
| 39 | Carbonic anhydrases: novel therapeutic applications for inhibitors and activators | Nature Reviews Drug Discovery | 2008 | 2,772 |
| 40 | Extracellular vesicles: biology and emerging therapeutic opportunities | Nature Reviews Drug Discovery | 2013 | 2,707 |
| 41 | Knocking down barriers: advances in siRNA delivery | Nature Reviews Drug Discovery | 2009 | 2,700 |
| 42 | pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures | Journal of Medicinal Chemistry | 2015 | 2,696 |
| 43 | Applications of Fluorine in Medicinal Chemistry | Journal of Medicinal Chemistry | 2015 | 2,659 |
| 44 | Anticancer activities of histone deacetylase inhibitors | Nature Reviews Drug Discovery | 2006 | 2,608 |
| 45 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules | Journal of Medicinal Chemistry | 1985 | 2,606 |
| 46 | Drug repositioning: identifying and developing new uses for existing drugs | Nature Reviews Drug Discovery | 2004 | 2,565 |
| 47 | Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties | Journal of Medicinal Chemistry | 2000 | 2,489 |
| 48 | The MicroRNA Spectrum in 12 Body Fluids | Clinical Chemistry | 2010 | 2,404 |
| 49 | Natural products in drug discovery: advances and opportunities | Nature Reviews Drug Discovery | 2021 | 2,404 |
| 50 | Design and development of polymers for gene delivery | Nature Reviews Drug Discovery | 2005 | 2,317 |
| 51 | Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design | Journal of Medicinal Chemistry | 2011 | 2,307 |
| 52 | Targeting the phosphoinositide 3-kinase pathway in cancer | Nature Reviews Drug Discovery | 2009 | 2,274 |
| 53 | Understanding biofilm resistance to antibacterial agents | Nature Reviews Drug Discovery | 2003 | 2,260 |
| 54 | Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer | Nature Reviews Drug Discovery | 2004 | 2,254 |
| 55 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies | Nature Reviews Drug Discovery | 2019 | 2,229 |
| 56 | Drugs for bad bugs: confronting the challenges of antibacterial discovery | Nature Reviews Drug Discovery | 2007 | 2,218 |
| 57 | The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics | Nature Reviews Drug Discovery | 2008 | 2,152 |
| 58 | The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates | Journal of Medicinal Chemistry | 2011 | 2,108 |
| 59 | Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. | Clinical Chemistry | 1982 | 2,089 |
| 60 | The evolving role of natural products in drug discovery | Nature Reviews Drug Discovery | 2005 | 2,073 |
| 61 | Dextran sulfate-Mg2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. | Clinical Chemistry | 1982 | 2,050 |
| 62 | The influence of drug-like concepts on decision-making in medicinal chemistry | Nature Reviews Drug Discovery | 2007 | 2,027 |
| 63 | Angiogenesis: an organizing principle for drug discovery? | Nature Reviews Drug Discovery | 2007 | 1,976 |
| 64 | The re-emergence of natural products for drug discovery in the genomics era | Nature Reviews Drug Discovery | 2015 | 1,973 |
| 65 | Protein kinases — the major drug targets of the twenty-first century? | Nature Reviews Drug Discovery | 2002 | 1,971 |
| 66 | MolDock: A New Technique for High-Accuracy Molecular Docking | Journal of Medicinal Chemistry | 2006 | 1,944 |
| 67 | Trends in GPCR drug discovery: new agents, targets and indications | Nature Reviews Drug Discovery | 2017 | 1,922 |
| 68 | Aptamers: An Emerging Class of Molecules That Rival Antibodies in Diagnostics | Clinical Chemistry | 1999 | 1,905 |
| 69 | Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery | Nature Reviews Drug Discovery | 2005 | 1,883 |
| 70 | Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib) | Journal of Medicinal Chemistry | 1997 | 1,881 |
| 71 | Rings in Drugs | Journal of Medicinal Chemistry | 2014 | 1,880 |
| 72 | Aptamers as therapeutics | Nature Reviews Drug Discovery | 2010 | 1,850 |
| 73 | The Properties of Known Drugs. 1. Molecular Frameworks | Journal of Medicinal Chemistry | 1996 | 1,844 |
| 74 | The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics | Nature Reviews Drug Discovery | 2011 | 1,825 |
| 75 | Peroxynitrite: biochemistry, pathophysiology and development of therapeutics | Nature Reviews Drug Discovery | 2007 | 1,773 |
| 76 | Molecular Similarity Indices in a Comparative Analysis (CoMSIA) of Drug Molecules to Correlate and Predict Their Biological Activity | Journal of Medicinal Chemistry | 1994 | 1,757 |
| 77 | Metabonomics: a platform for studying drug toxicity and gene function | Nature Reviews Drug Discovery | 2002 | 1,756 |
| 78 | Delivery technologies for cancer immunotherapy | Nature Reviews Drug Discovery | 2019 | 1,745 |
| 79 | Protein therapeutics: a summary and pharmacological classification | Nature Reviews Drug Discovery | 2008 | 1,740 |
| 80 | A comprehensive map of molecular drug targets | Nature Reviews Drug Discovery | 2017 | 1,736 |
| 81 | Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects | Journal of Medicinal Chemistry | 2006 | 1,722 |
| 82 | The PPARs: From Orphan Receptors to Drug Discovery | Journal of Medicinal Chemistry | 2000 | 1,721 |
| 83 | Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design | Journal of Medicinal Chemistry | 2018 | 1,706 |
| 84 | Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking | Journal of Medicinal Chemistry | 2012 | 1,694 |
| 85 | Cyclodextrin-based pharmaceutics: past, present and future | Nature Reviews Drug Discovery | 2004 | 1,687 |
| 86 | Hydrogen sulphide and its therapeutic potential | Nature Reviews Drug Discovery | 2007 | 1,653 |
| 87 | Designing antimicrobial peptides: form follows function | Nature Reviews Drug Discovery | 2012 | 1,636 |
| 88 | mRNA-based therapeutics — developing a new class of drugs | Nature Reviews Drug Discovery | 2014 | 1,635 |
| 89 | Expressing the Modification of Diet in Renal Disease Study Equation for Estimating Glomerular Filtration Rate with Standardized Serum Creatinine Values | Clinical Chemistry | 2007 | 1,620 |
| 90 | Strategies and challenges for the next generation of antibody–drug conjugates | Nature Reviews Drug Discovery | 2017 | 1,620 |
| 91 | Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities | Nature Reviews Drug Discovery | 2008 | 1,611 |
| 92 | The FGF family: biology, pathophysiology and therapy | Nature Reviews Drug Discovery | 2009 | 1,592 |
| 93 | Diagnosing the decline in pharmaceutical R&D efficiency | Nature Reviews Drug Discovery | 2012 | 1,583 |
| 94 | ADMET in silico modelling: towards prediction paradise? | Nature Reviews Drug Discovery | 2003 | 1,570 |
| 95 | Applications of machine learning in drug discovery and development | Nature Reviews Drug Discovery | 2019 | 1,565 |
| 96 | Lab-on-a-chip: microfluidics in drug discovery | Nature Reviews Drug Discovery | 2006 | 1,559 |
| 97 | Discovery and development of sorafenib: a multikinase inhibitor for treating cancer | Nature Reviews Drug Discovery | 2006 | 1,557 |
| 98 | Drugging the undruggable RAS: Mission Possible? | Nature Reviews Drug Discovery | 2014 | 1,557 |
| 99 | How were new medicines discovered? | Nature Reviews Drug Discovery | 2011 | 1,555 |
| 100 | The Future of Peptide‐based Drugs | Chemical Biology and Drug Design | 2013 | 1,554 |
