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Most Cited Articles of Systems Biology in 2012

TitleJournalYearCitations
Differential network biologyMolecular Systems Biology2012538
Novel biomarkers for pre-diabetes identified by metabolomicsMolecular Systems Biology2012468
The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loopsMolecular Systems Biology2012303
HINT: High-quality protein interactomes and their applications in understanding human diseaseBMC Systems Biology2012268
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cellsMolecular Systems Biology2012266
TIGRESS: Trustful Inference of Gene REgulation using Stability SelectionBMC Systems Biology2012218
Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encodingWiley Interdisciplinary Reviews: Systems Biology and Medicine2012214
Comparative transcriptomics of pathogenic and non-pathogenic Listeria speciesMolecular Systems Biology2012198
Reconstruction of genome-scale metabolic models for 126 human tissues using mCADREBMC Systems Biology2012191
Effects of diet and development on the Drosophila lipidomeMolecular Systems Biology2012182
Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinomaMolecular Systems Biology2012174
Deciphering a global network of functionally associated post-translational modificationsMolecular Systems Biology2012171
Systems-based analysis of Arabidopsis leaf growth reveals adaptation to water deficitMolecular Systems Biology2012163
A new essential protein discovery method based on the integration of protein-protein interaction and gene expression dataBMC Systems Biology2012156
Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterningBioSystems2012150
A mechanism for robust circadian timekeeping via stoichiometric balanceMolecular Systems Biology2012146
A systems biology approach to synovial joint lubrication in health, injury, and diseaseWiley Interdisciplinary Reviews: Systems Biology and Medicine2012146
Global biogeography of SAR11 marine bacteriaMolecular Systems Biology2012146
Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacteriumMolecular Systems Biology2012144
Global microRNA level regulation of EGFR-driven cell-cycle protein network in breast cancerMolecular Systems Biology2012144
CellNOptR: a flexible toolkit to train protein signaling networks to data using multiple logic formalismsBMC Systems Biology2012132
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell deathMolecular Systems Biology2012132
INDI: a computational framework for inferring drug interactions and their associated recommendationsMolecular Systems Biology2012131
The role of pectin in plant morphogenesisBioSystems2012130
Regulation of yeast central metabolism by enzyme phosphorylationMolecular Systems Biology2012127