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Most Cited Articles of Systems Biology in 2005

TitleJournalYearCitations
A comprehensive pathway map of epidermal growth factor receptor signalingMolecular Systems Biology2005730
A uniform proteomics MS/MS analysis platform utilizing open XML file formatsMolecular Systems Biology2005574
Phosphotyrosine interactome of the ErbB-receptor kinase familyMolecular Systems Biology2005399
Extension of a genetic network model by iterative experimentation and mathematical analysisMolecular Systems Biology2005282
A global view of pleiotropy and phenotypically derived gene function in yeastMolecular Systems Biology2005232
Refactoring bacteriophage T7Molecular Systems Biology2005203
A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coliMolecular Systems Biology2005135
Analysis of synonymous codon usage in H5N1 virus and other influenza A virusesBioSystems2005118
The origin of the genetic code: theories and their relationships, a reviewBioSystems2005109
Gene function prediction from congruent synthetic lethal interactions in yeastMolecular Systems Biology2005101
A mathematical model of combination therapy using the EGFR signaling networkBioSystems200584
Dynamics of pruning in simulated large-scale spiking neural networksBioSystems200578
Threshold responses to morphogen gradients by zero-order ultrasensitivityMolecular Systems Biology200573
Monitoring dynamics of single-cell gene expression over multiple cell cyclesMolecular Systems Biology200573
p53-Mdm2 loop controlled by a balance of its feedback strength and effective dampening using ATM and delayed feedbackIET Systems Biology200573
Public-key system using DNA as a one-way function for key distributionBioSystems200573
Sustainable systems as organisms?BioSystems200570
Expression dynamics of a cellular metabolic networkMolecular Systems Biology200561
The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformationMolecular Systems Biology200560
A theoretical framework for specificity in cell signalingMolecular Systems Biology200557
Algorithmic approaches for computing elementary modes in large biochemical reaction networksIET Systems Biology200557
A measure of local variation of inter-spike intervalsBioSystems200555
Robustness properties of apoptosis models with respect to parameter variations and intrinsic noiseIET Systems Biology200555
Model identification of signal transduction networks from data using a state regulator problemIET Systems Biology200554
Combinatorial complexity and dynamical restriction of network flows in signal transductionIET Systems Biology200550