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#	Title	Journal	Year	Citations
1	Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4	Nature	1970	253,557
2	DNA sequencing with chain-terminating inhibitors	Proceedings of the National Academy of Sciences of the United States of America	1977	68,426
3	Electric Field Effect in Atomically Thin Carbon Films	Science	2004	56,177
4	Deep learning	Nature	2015	52,813
5	Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.	Proceedings of the National Academy of Sciences of the United States of America	1979	52,015
6	Helical microtubules of graphitic carbon	Nature	1991	39,105
7	Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles	Proceedings of the National Academy of Sciences of the United States of America	2005	38,922
8	Optimization by Simulated Annealing	Science	1983	35,496
9	Collective dynamics of ‘small-world’ networks	Nature	1998	34,143
10	Electrochemical Photolysis of Water at a Semiconductor Electrode	Nature	1972	28,828
11	Emergence of Scaling in Random Networks	Science	1999	28,383
12	A low-cost, high-efficiency solar cell based on dye-sensitized colloidal TiO2 films	Nature	1991	26,665
13	Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness	Scientific Reports	2017	26,112
14	Judgment under Uncertainty: Heuristics and Biases	Science	1974	23,858
15	Biodiversity hotspots for conservation priorities	Nature	2000	22,192
16	Initial sequencing and analysis of the human genome	Nature	2001	21,074
17	Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease	Scientific Reports	2016	20,953
18	The Tragedy of the Commons	Science	1968	20,183
19	Learning representations by back-propagating errors	Nature	1986	19,202
20	Two-dimensional gas of massless Dirac fermions in graphene	Nature	2005	18,948
21	Multilineage Potential of Adult Human Mesenchymal Stem Cells	Science	1999	18,830
22	Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles	Scientific Reports	2019	17,835
23	Highly accurate protein structure prediction with AlphaFold	Nature	2021	17,754
24	Issues and challenges facing rechargeable lithium batteries	Nature	2001	17,629
25	Measurement of the Elastic Properties and Intrinsic Strength of Monolayer Graphene	Science	2008	17,513
26	A pneumonia outbreak associated with a new coronavirus of probable bat origin	Nature	2020	17,004
27	Continuous cultures of fused cells secreting antibody of predefined specificity	Nature	1975	16,707
28	Building better batteries	Nature	2008	16,547
29	Human-level control through deep reinforcement learning	Nature	2015	15,934
30	Re-epithelialization and immune cell behaviour in an ex vivo human skin model	Scientific Reports	2020	15,895
31	An integrated encyclopedia of DNA elements in the human genome	Nature	2012	15,516
32	Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism	Nature	1992	15,429
33	The value of the world's ecosystem services and natural capital	Nature	1997	15,321
34	Neural networks and physical systems with emergent collective computational abilities.	Proceedings of the National Academy of Sciences of the United States of America	1982	15,174
35	Reducing the Dimensionality of Data with Neural Networks	Science	2006	14,686
36	C60: Buckminsterfullerene	Nature	1985	14,587
37	In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus	Scientific Reports	2018	14,531
38	Cluster analysis and display of genome-wide expression patterns	Proceedings of the National Academy of Sciences of the United States of America	1998	14,487
39	A global reference for human genetic variation	Nature	2015	13,998
40	phyloseq: An R Package for Reproducible Interactive Analysis and Graphics of Microbiome Census Data	PLoS ONE	2013	13,960
41	One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products	Proceedings of the National Academy of Sciences of the United States of America	2000	13,843
42	Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase	Science	1988	13,840
43	Embryonic Stem Cell Lines Derived from Human Blastocysts	Science	1998	13,539
44	Molecular portraits of human breast tumours	Nature	2000	13,397
45	The Framing of Decisions and the Psychology of Choice	Science	1981	13,316
46	Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans	Nature	1998	13,137
47	Dendritic cells and the control of immunity	Nature	1998	13,114
48	Optical Coherence Tomography	Science	1991	13,009
49	A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity	Science	2012	12,811
50	Multiplex Genome Engineering Using CRISPR/Cas Systems	Science	2013	12,725
51	Inflammation and cancer	Nature	2002	12,666
52	The Sequence of the Human Genome	Science	2001	12,623
53	Positional cloning of the mouse obese gene and its human homologue	Nature	1994	12,218
54	Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase	Science	1988	12,204
55	Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation	Science	2009	12,186
56	Experimental observation of the quantum Hall effect and Berry's phase in graphene	Nature	2005	12,153
57	Graphene: Status and Prospects	Science	2009	12,120
58	The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics	Science	2002	12,113
59	Nonlinear Dimensionality Reduction by Locally Linear Embedding	Science	2000	12,086
60	The Chemistry and Applications of Metal-Organic Frameworks	Science	2013	12,032
61	Photoelectrochemical cells	Nature	2001	11,931
62	Community structure in social and biological networks	Proceedings of the National Academy of Sciences of the United States of America	2002	11,888
63	Electrical Energy Storage for the Grid: A Battery of Choices	Science	2011	11,724
64	Graphene-based composite materials	Nature	2006	11,655
65	Visible-Light Photocatalysis in Nitrogen-Doped Titanium Oxides	Science	2001	11,440
66	On the Origin of Cancer Cells	Science	1956	11,358
67	FastTree 2 – Approximately Maximum-Likelihood Trees for Large Alignments	PLoS ONE	2010	11,284
68	Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid	Nature	1953	11,205
69	The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine	Nature	1980	11,108
70	Light-emitting diodes based on conjugated polymers	Nature	1990	10,985
71	The plant immune system	Nature	2006	10,939
72	Improved tools for biological sequence comparison.	Proceedings of the National Academy of Sciences of the United States of America	1988	10,937
73	Triblock Copolymer Syntheses of Mesoporous Silica with Periodic 50 to 300 Angstrom Pores	Science	1998	10,937
74	A Global Geometric Framework for Nonlinear Dimensionality Reduction	Science	2000	10,827
75	Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene	Science	1987	10,804
76	Tissue-based map of the human proteome	Science	2015	10,802
77	Learning the parts of objects by non-negative matrix factorization	Nature	1999	10,768
78	A synaptic model of memory: long-term potentiation in the hippocampus	Nature	1993	10,699
79	Effects of Thymoquinone on radiation enteritis in mice	Scientific Reports	2018	10,654
80	A novel potent vasoconstrictor peptide produced by vascular endothelial cells	Nature	1988	10,647
81	Semiconductor Clusters, Nanocrystals, and Quantum Dots	Science	1996	10,633
82	Significance analysis of microarrays applied to the ionizing radiation response	Proceedings of the National Academy of Sciences of the United States of America	2001	10,626
83	A default mode of brain function	Proceedings of the National Academy of Sciences of the United States of America	2001	10,607
84	Surface plasmon subwavelength optics	Nature	2003	10,571
85	Bacterial Biofilms: A Common Cause of Persistent Infections	Science	1999	10,329
86	Comprehensive molecular portraits of human breast tumours	Nature	2012	10,282
87	Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor	Nature	1987	10,262
88	Two-dimensional atomic crystals	Proceedings of the National Academy of Sciences of the United States of America	2005	10,229
89	The pathogenesis of atherosclerosis: a perspective for the 1990s	Nature	1993	10,206
90	Spintronics: A Spin-Based Electronics Vision for the Future	Science	2001	10,189
91	The Evolution of Cooperation	Science	1981	10,174
92	Array programming with NumPy	Nature	2020	10,143
93	Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring	Science	1999	10,140
94	An obesity-associated gut microbiome with increased capacity for energy harvest	Nature	2006	10,136
95	Large-Area Synthesis of High-Quality and Uniform Graphene Films on Copper Foils	Science	2009	10,000
96	The functions of animal microRNAs	Nature	2004	9,846
97	Mastering the game of Go with deep neural networks and tree search	Nature	2016	9,796
98	Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications	Proceedings of the National Academy of Sciences of the United States of America	2001	9,721
99	Large-scale pattern growth of graphene films for stretchable transparent electrodes	Nature	2009	9,624
100	Structure, function and diversity of the healthy human microbiome	Nature	2012	9,614

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