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Adult Survivors of Pediatric Cancer: Risk of Cardiovascular Disease

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Pediatric Cancer, Volume 2

Part of the book series: Pediatric Cancer ((PECA,volume 2))

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Abstract

With contemporary therapy, approximately 75% of children diagnosed with central nervous system (CNS) tumors are expected to be 5-year survivors. With increased survival, there is an increased emphasis on better understanding cancer-related late adverse effects, including premature development of cardiovascular disease. Due to the nature of CNS tumors and its treatment, survivors are at increased risk of various neuroendocrine deficiencies that increase risk of obesity, dyslipidemia, and hypertension. Radiation exposure to the heart and some chemotherapeutic agents also are associated with primary cardiomyopathy. Together, these factors likely contribute to the observed increase in cardiovascular disease risk seen in both small and large cohort studies of childhood CNS tumor survivors. In response, cancer survivor-specific health screening guidelines have been published in an attempt to detect early manifestations of cardiovascular disease and hopefully prevent more serious morbidity. In addition to describing the magnitude and risk factors associated with these adverse cardiovascular outcomes, there also is ongoing research focused on understanding genetic determinants of treatment-related sequelae as well as promoting healthier lifestyles.

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Authors and Affiliations

  1. Hematology-Oncology, Seattle Children’s Hospital, Fred Hutchinson Cancer Research Center, 19024, M4-C308, Seattle, WA, 98109, USA

    Eric Chow

  2. Hematology/Oncology and Endocrinology, Emory University, 2015 Uppergate Drive Northeast, Atlanta, GA, 30322, USA

    Lillian Meacham

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  1. Eric Chow
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  2. Lillian Meacham
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Correspondence to Eric Chow .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Chow, E., Meacham, L. (2012). Adult Survivors of Pediatric Cancer: Risk of Cardiovascular Disease. In: Hayat, M. (eds) Pediatric Cancer, Volume 2. Pediatric Cancer, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2957-5_24

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