Abstract
The goal of dose-response assessment is to quantitatively describe the relationship between the extent of exposure (the dose) and the likelihood of adverse health effects (responses). The outcome of dose-response assessment is a value which, when combined with the exposure estimate, will allow an estimation of health risk. Key tasks in dose-response assessment are the compilation of dose-response data from animal and human toxicology studies, selection of the most sensitive and convincing health effects or endpoints, identification of a suitable no or minimal effect dose associated with those effects, and selection of uncertainty factors and dose-response models that can be used to derive a safe level for human exposure.
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USEPA, 1993. Reference Dose (RfD): Description and Use in Health Risk Assessments Background Document 1A March 15, 1993. http://www.epa.gov/iris/rfd.htm.
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Lewandowski, T., Norman, J. (2015). Dose-Response Assessment. In: Torres, J., Bobst, S. (eds) Toxicological Risk Assessment for Beginners. Springer, Cham. https://doi.org/10.1007/978-3-319-12751-4_3
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