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Cross-specialty PROMIS-global health differential item functioning

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Abstract

Purpose

To investigate the functioning of the PROMIS-Global Health (PROMIS-GH) across clinical setting, patient age, and medical complexity by evaluating differential item functioning (DIF) within the Global Physical Health (GPH) and Global Mental Health (GMH) domains. To our knowledge, no study demonstrates lack of differential item functioning (DIF) for PROMIS-GH across these populations. We hypothesize that the PROMIS-GH domains of GMH and GPH will perform similarly when compared across these populations.

Methods

Seven thousand nine hundred and seventy four complete PROMIS Global Health measures were retrospectively analyzed using the ‘Lordif’ package on the R platform. DIF was investigated for both GMH and GPH across clinical environment (Orthopedic Surgery, Family Medicine, & Internal Medicine), age group (≤ 53, > 53–66, > 66), and Charlson Comorbidity Index (CCI:0, CCI:1, CCI:2 +) using quasi Monte Carlo estimation. To assess the significance of DIF, Wald tests were used with the Benjamini & Hochberg procedure.

Results

No items contained in the GMH or GPH demonstrated DIF across age groups, medical complexity, or clinical environment.

Conclusion

Items assessing the domains of GMH and GPH within the PROMIS–GH function comparably across treatment setting, age category, and medical comorbidities. The PROMIS–Global Health holds potential to facilitate interdisciplinary patient care and patient optimization prior to surgical intervention.

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Code availability

Analysis were performed in R.

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Funding

This project had no external funding.

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Correspondence to James J. Gregory.

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Ethical approval

Study approved by Dartmouth College by Institutions Ethics Board, approval number STUDY00031786.

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This study was submitted for IRB approval and deemed exempt from requiring patient consent.

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Gregory, J.J., Werth, P.M., Reilly, C.A. et al. Cross-specialty PROMIS-global health differential item functioning. Qual Life Res 30, 2339–2348 (2021). https://doi.org/10.1007/s11136-021-02812-6

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