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Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study

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Abstract

Data on the occurrence and clinicopathological characteristics of actinic cheilitis (AC) and lip squamous cell carcinoma (LSCC) are well studied; however, they are based on studies limited to a single centre. Herein, we described the frequency of AC and LSCC submitted to microscopic examination from representative geographic regions of Brazil. A retrospective multicentre study was performed on biopsies obtained from 1953 to 2018 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,709 biopsy specimens were surveyed. Sociodemographic data and clinicopathologic characteristics were analysed. A total of 2017 cases of ACs (1.0%) and 850 cases of LSCCs (0.4%) were recorded. A strong fair-skinned (> 87%) male (> 70%) predilection was observed in both conditions. The mean age was 54.8 ± 18.7 for individuals with AC and 57.8 ± 19.0 for individuals with LSCC. The most commonly affected site was the lower lip (> 90%). This is a large multicentre study of AC and LSCC from Brazil. The frequency and clinicopathological features of AC and LSCC were similar to those described worldwide. This study provides robust and representative epidemiological data of these conditions for the scientific community.

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Acknowledgements

This work was supported by the Brazilian National Council for Scientific and Technological Development (CNPq #305493/2018-3, #455644/2018-1). The authors thank the Coordination for the Improvement of Higher Education Personnel (CAPES, Finance code 001), Brazil. L.V.O.S. and J.A.A.A. are the recipients of fellowships. We would like to extend our thanks to Dr. L. Barnabé for technical assistance with histopathological photomicrographs. Mrs. E. Greene provided English editing of the manuscript.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Finance Code 001), Brazil.

Author information

Authors and Affiliations

  1. Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Leni Verônica de Oliveira Silva, José Alcides Almeida de Arruda & Ricardo Alves Mesquita

  2. Department of Paediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Lucas Guimarães Abreu

  3. Department of Social and Preventive Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil

    Raquel Conceição Ferreira

  4. Postgraduate Program in Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil

    Leorik Pereira da Silva & Lélia Batista de Souza

  5. Department of Oral and Maxillofacial Pathology, School of Dentistry, Universidade de São Paulo, São Paulo, SP, Brazil

    Cibele Pelissari & Marília Trierveiler

  6. Department of Stomatology (Oral Pathology), School of Dentistry, Universidade Federal de Goiás, Goiânia, GO, Brazil

    Ricardo Natã Fonseca Silva & Elismauro Francisco Mendonça

  7. Diagnostic Centre for Oral Diseases, School of Dentistry, Universidade Federal de Pelotas, Pelotas, RS, Brazil

    Kaio Heide Sampaio Nóbrega & Ana Paula Neutzling Gomes

  8. Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    Bruno Augusto Benevenuto de Andrade, Mario José Romañach & Michelle Agostini

  9. Department of Dentistry, Universidade Estadual da Paraíba, Campina Grande, PB, Brazil

    Cassiano Francisco Weege Nonaka & Pollianna Muniz Alves

  10. Service of Oral Pathology, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, PA, Brazil

    Hélder Antônio Rebelo Pontes

  11. Department of Pathology, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Luís Fernando Rivero

  12. Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Manoela Domingues Martins

  13. Department of Oral Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil

    Manoela Domingues Martins

  14. Department of Oral and Maxillofacial Surgery and Pathology, School of Dentistry, Universidade de Pernambuco, Camaragibe, PE, Brazil

    Emanuel Sávio de Souza Andrade, Marcia Maria Fonseca da Silveira & Ana Paula Veras Sobral

  15. Departamento de Clínica, Patologia e Cirurgias Odontológicas, Faculdade de Odontologia, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, sala 3202 D. Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil

    Leni Verônica de Oliveira Silva

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  1. Leni Verônica de Oliveira Silva
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Correspondence to Leni Verônica de Oliveira Silva.

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The study was approved by the Human Research Ethics Committee of the study institution (No. 2.936.807).

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Silva, L.V.d., de Arruda, J.A.A., Abreu, L.G. et al. Demographic and Clinicopathologic Features of Actinic Cheilitis and Lip Squamous Cell Carcinoma: a Brazilian Multicentre Study. Head and Neck Pathol 14, 899–908 (2020). https://doi.org/10.1007/s12105-020-01142-2

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