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Imaginological characterization of multiple myeloma lesions of the jaws through cone-beam computed tomography

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Abstract

Purpose

To establish an evaluation protocol for the identification and description of the variations in multiple myeloma (MM) lesions of the jaws, by means of cone-beam computed tomography (CBCT).

Materials and methods

Tomography exams from 33 MM patients were evaluated in this retrospective observational study. The reconstructions were analyzed simultaneously, according to the established protocol, with the following description criteria: anatomic location, size, margins, inner aspect, relationship with adjacent structures, and presence or absence of a punched-out aspect. The exams were further subdivided into groups of patients using, or not bisphosphonates.

Results

There were osteolytic lesions in 100% of cases, most of which were extended to more than one anatomical region. Poorly defined margins were more frequent in the maxilla than in the mandible. Extensive bone resorption presenting multilocular areas was the most frequently observed aspect, being 86.2% for maxilla and 87.9% for mandible. In relation to bisphosphonates, patients who used the medication had more poorly defined bone margins and contortions (68.6%) than those who did not undergo drug therapy (31.4%). No well-defined lesions were observed (p = 0.34%).

Conclusion

It was possible to establish a protocol for evaluation of MM lesions in CBCT images and to identify that when evaluated three-dimensional, lesions tend to be poorly defined and have no pattern of description, as described in two-dimensional “punched-out”.

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Acknowledgements

We would like to thank Research Support Foundation of Rio de Janeiro (Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro, FAPERJ), the School of Dentistry of Universidade Federal do Rio de Janeiro, and Hospital Universitário Clementino Fraga Filho (HUCFF) for their support.

Funding

This study was financially supported by the Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), process E-26/103.046/2012, Grants to Sandra R. Torres. This institution had no involvement either in study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the article for publication.

Author information

Authors and Affiliations

  1. Department of Oral Pathology and Diagnosis, School of Dentistry, Dental Clinic, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Thaiza Gonçalves Rocha

  2. School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Édila Figuerêdo Feitosa

  3. Medical Clinic, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Ângelo Maiolino

  4. University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Roberto José Pessoa de Magalhães Filho

  5. Department of Oral Pathology and Diagnosis, School of Dentistry, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 325, Cidade Universitária, Rio de Janeiro, RJ, 21941-617, Brazil

    Fábio Ribeiro Guedes, Sandra Regina Torres & Maria Augusta Visconti

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  1. Thaiza Gonçalves Rocha
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Corresponding author

Correspondence to Maria Augusta Visconti.

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Conflict of interest

Author Thaiza Gonçalves Rocha, Author Édila Figuerêdo Feitosa, Author Ângelo Maiolino, Author Roberto José Pessoa de Magalhães Filho, Author Fábio Ribeiro Guedes, Author Sandra Regina Torres, Author Maria Augusta Visconti declare that they have no conflict of interest.

Ethical approval

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.

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Rocha, T.G., Feitosa, É.F., Maiolino, Â. et al. Imaginological characterization of multiple myeloma lesions of the jaws through cone-beam computed tomography. Oral Radiol 36, 168–176 (2020). https://doi.org/10.1007/s11282-019-00394-1

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  • DOI: https://doi.org/10.1007/s11282-019-00394-1

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