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Coexistence of urinary incontinence and major depressive disorder with health-related quality of life in older Americans with and without cancer

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Abstract

Purpose

This study evaluates the prevalence and factors associated with major depressive disorder (MDD) in a population of cancer survivors and the impact of co-occurring MDD and urinary incontinence (UI) on health-related quality of life (HRQOL).

Methods

The prevalence of MDD risk among cancer survivors (breast, prostate, bladder, colorectal, lung, and endometrial/uterine cancers) and those without cancer was estimated using the Surveillance, Epidemiology and End Results Program-Medicare Health Outcomes Survey (SEER-MHOS) linked database (n = 9,282 with cancer/n = 289,744 without cancer). Risk for MDD was measured using three items from the Diagnostic Interview Schedule, and HRQOL was measured by the SF-36. UI was defined as self-reported leakage of urine causing a problem in previous 6 months. Factors associated with MDD were investigated using logistic regression, and the impact of co-occurring MDD and UI on HRQOL scores was determined using linear regression.

Results

The prevalence of MDD risk ranged from 19.2 % for prostate to 34.1 % for lung. Lung cancer diagnosis was associated with risk of MDD. Being ≥5 years from diagnosis was associated with decreased risk of MDD (prevalence odds ratio (POR) = 0.82, 95 % confidence interval (95 % CI) 0.71, 0.95). The coexistence of both UI and MDD was associated with a decrease across HRQOL subscales; including 40 points on role-emotional (RE) score.

Conclusions

Cancer survivors reporting co-occurrence of UI and MDD experienced significant decrements in HRQOL.

Implications of Cancer Survivors

Understanding the combined effect of UI and MDD may help clinicians to better recognize and alleviate their effects on cancer survivors’ HRQOL.

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Acknowledgments

This study is supported in part by grant ES07018 from the National Institute of Environmental Health Sciences and by the UNC Lineberger Cancer Control Education Program (R25 CA57726).

Conflict of interest

The authors have no conflicts of interest or financial disclosures.

Author information

Authors and Affiliations

  1. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, 27599-7435, USA

    Alexandra J. White & Debra E. Irwin

  2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA

    Bryce B. Reeve, Ronald C. Chen, Angela M. Stover & Debra E. Irwin

  3. Department of Health Policy and Management, University of North Carolina, Chapel Hill, NC, USA

    Bryce B. Reeve

  4. Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA

    Ronald C. Chen

  5. Department of Health Behavior, University of North Carolina, Chapel Hill, NC, USA

    Angela M. Stover

Authors
  1. Alexandra J. White
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  2. Bryce B. Reeve
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  5. Debra E. Irwin
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Correspondence to Alexandra J. White.

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White, A.J., Reeve, B.B., Chen, R.C. et al. Coexistence of urinary incontinence and major depressive disorder with health-related quality of life in older Americans with and without cancer. J Cancer Surviv 8, 497–507 (2014). https://doi.org/10.1007/s11764-014-0360-8

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  • DOI: https://doi.org/10.1007/s11764-014-0360-8

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