Abstract
The molecular complexation of triterpene glycosides α-hederin (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranoside), hederasaponin C (hederagenin 3-O-α-L-rhamnopyranosyl-(l → 2)-O-α-L-arabinopyranosyl-28-O-α-L-rhamnopyranosyl-(l → 4)-O-β-D-glucopyranosyl-(l → 6)-O-β-D-glucopyranoside), and glycyram (monoammonium glycyrrhizinate) with sildenafil citrate was investigated for the first time using electrospray ionization mass spectroscopy. The glycosides form a complex in a 1: 1 molar ratio. The influence of the complex on Avena sativa seeds germination and its ichthyotoxicity against Poecilia reticulata were studied.
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Original Russian Text © L.A. Yakovishin, A.V. Lekar, E.V. Vetrova, N.I. Borisenko, S.N. Borisenko, V.I. Grishkovets, 2013, published in Khimiya Rastitel’nogo Syr’ya, 2013, No. 3, pp. 99–105.
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Yakovishin, L.A., Lekar, A.V., Vetrova, E.V. et al. Molecular complexes of ivy and licorice saponins with sildenafil citrate (Viagra) and their biological activity. Russ J Bioorg Chem 40, 737–741 (2014). https://doi.org/10.1134/S1068162014070188
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DOI: https://doi.org/10.1134/S1068162014070188