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Acknowledgements
We thank Ferdi Grawe (Heinrich-Heine-University, Düsseldorf) for helping us to obtain exosome images and Andre Görgens for general discussion. We are grateful for the technical support of Sabine Schramm and Monika Collenburg and we thank Elisabeth H Weiss (Ludwig-Maximilians-University Munich) and Britta Eiz-Vesper (Hannover Medical School) for providing modified K562 cell line cells and Nahid Kordelas for proofreading.
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PAH, DB and BG designed the study; LK and DB treated the patients; A-KL, SR and TRD raised cells and purified exosomes; VR, A-KL and JR characterized exosomes; VR performerd immune assays; LK, VR and BG wrote the paper; All authors discussed the data and the manuscript.
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A patent entitled ‘Use of preparations comprising exosomes derived from mesenchymal stem cells (MSCs) in the prevention and therapy of inflammatory conditions’ has been submitted.
Supplementary Information accompanies this paper on the Leukemia website
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Kordelas, L., Rebmann, V., Ludwig, AK. et al. MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. Leukemia 28, 970–973 (2014). https://doi.org/10.1038/leu.2014.41
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DOI: https://doi.org/10.1038/leu.2014.41
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