Skip to main content

Advertisement

SpringerLink
Log in

Transient bilateral vestibular dysfunction caused by intoxication with low doses of styrene

  • Case Report
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Neuhauser HK (2007) Epidemiology of vertigo. Curr Opin Neurol 20:40–46

    Article  PubMed  Google Scholar 

  2. Zingler VC, Weintz E, Jahn K, Huppert D, Cnyrim C, Brandt T, Strupp M (2009) Causative factors, epidemiology, and follow-up of bilateral vestibulopathy. Ann N Y Acad Sci 1164:505–508

    Article  PubMed  Google Scholar 

  3. Zingler VC, Weintz E, Jahn K, Mike A, Huppert D, Rettinger N, Brandt T, Strupp M (2008) Follow-up of vestibular function in bilateral vestibulopathy. J Neurol Neurosurg Psychiatry 79:284–288

    Article  CAS  PubMed  Google Scholar 

  4. Halmagyi GM, Curthoys IS (1988) A clinical sign of canal paresis. Arch Neurol 45:737–739

    Article  CAS  PubMed  Google Scholar 

  5. Krafczyk S, Tietze S, Swoboda W, Valkovic P, Brandt T (2006) Artificial neural network: a new diagnostic posturographic tool for disorders of stance. Clin Neurophysiol Off J Int Fed Clin Neurophysiol 117:1692–1698

    Article  Google Scholar 

  6. Schniepp R, Wuehr M, Neuhaeusser M, Kamenova M, Dimitriadis K, Klopstock T, Strupp M, Brandt T, Jahn K (2012) Locomotion speed determines gait variability in cerebellar ataxia and vestibular failure. Mov Disord Off J Mov Disord Soc 27:125–131

    Article  Google Scholar 

  7. Baloh RW, Honrubia V, Yee RD, Hess K (1984) Changes in the human vestibulo-ocular reflex after loss of peripheral sensitivity. Ann Neurol 16:222–228

    Article  CAS  PubMed  Google Scholar 

  8. Schmid-Priscoveanu A, Böhmer A, Obzina H, Straumann D (2001) Caloric and search-coil head-impulse testing in patients after vestibular neuritis. J Assoc Res Otolaryngol JARO 2:72–78

    CAS  Google Scholar 

  9. Hodgkinson L, Prasher D (2006) Effects of industrial solvents on hearing and balance: a review. Noise Heal 8:114–133

    Article  Google Scholar 

  10. Sagunski, H (1998) Richtwerte für die Innenraumluft: Styrol. Bundesgesundheitsblatt 392–421. http://www.umweltbundesamt.de/sites/default/files/medien/pdfs/Styrol.pdf

  11. World Health Organization (2000) Regional Office for Europe: air quality guidelines for Europe. http://www.euro.who.int/__data/assets/pdf_file/0005/74732/E71922.pdf

  12. Bundesanstalt für Arbeitsschutz und Arbeitsmedizin: Technische Regeln für Gefahrenstoffe (TRGS 900) (2006) http://www.baua.de/de/Themen-von-A-Z/Gefahrstoffe/TRGS/pdf/TRGS-900.pdf?__blob=publicationFile&v=15

  13. Wieczorek H, Piotrowski JK (1985) Evaluation of low exposure to styrene. I. Absorption of styrene vapours by inhalation under experimental conditions. Int Arch Occup Environ Health 57:57–69

    Article  CAS  PubMed  Google Scholar 

  14. Wieczorek H (1985) Evaluation of low exposure to styrene. II. Dermal absorption of styrene vapours in humans under experimental conditions. Int Arch Occup Environ Health 57:71–75

    Article  CAS  PubMed  Google Scholar 

  15. Withey JR (1978) The toxicology of styrene monomer and its pharmacokinetics and distribution in the rat. Scand J Work Environ Health 4(Suppl 2):31–40

    Article  CAS  PubMed  Google Scholar 

  16. Hoet P, Lison D (2008) Ototoxicity of toluene and styrene: state of current knowledge. Crit Rev Toxicol 38:127–170

    Article  CAS  PubMed  Google Scholar 

  17. Rebert CS, Hall TA (1994) The neuroepidemiology of styrene: a critical review of representative literature. Crit Rev Toxicol 24(Suppl):S57–S106

    Article  PubMed  Google Scholar 

  18. Campo P, Loquet G, Blachère V, Roure M (1999) Toluene and styrene intoxication route in the rat cochlea. Neurotoxicol Teratol 21:427–434

    Article  CAS  PubMed  Google Scholar 

  19. Campo P, Lataye R, Loquet G, Bonnet P (2001) Styrene-induced hearing loss: a membrane insult. Hear Res 154:170–180

    Article  CAS  PubMed  Google Scholar 

  20. Morata TC, Campo P (2002) Ototoxic effects of styrene alone or in concert with other agents: a review. Noise Heal 4:15–24

    Google Scholar 

  21. Lataye R, Campo P, Barthelemy C, Loquet G, Bonnet P (2001) Cochlear pathology induced by styrene. Neurotoxicol Teratol 23:71–79

    Article  CAS  PubMed  Google Scholar 

  22. Chen G-D, Tanaka C, Henderson D (2008) Relation between outer hair cell loss and hearing loss in rats exposed to styrene. Hear Res 243:28–34

    Article  CAS  PubMed  Google Scholar 

  23. Sułkowski WJ, Kowalska S, Matyja W, Guzek W, Wesołowski W, Szymczak W, Kostrzewski P (2002) Effects of occupational exposure to a mixture of solvents on the inner ear: a field study. Int J Occup Med Environ Health 15:247–256

    PubMed  Google Scholar 

  24. Morata TC, Johnson A-C, Nylen P, Svensson EB, Cheng J, Krieg EF, Lindblad A-C, Ernstgård L, Franks J (2002) Audiometric findings in workers exposed to low levels of styrene and noise. J Occup Environ Med Am Coll Occup Environ Med 44:806–814

    Article  Google Scholar 

  25. Sass-Kortsak AM, Corey PN, Robertson JM (1995) An investigation of the association between exposure to styrene and hearing loss. Ann Epidemiol 5:15–24

    Article  CAS  PubMed  Google Scholar 

  26. Möller C, Odkvist L, Larsby B, Tham R, Ledin T, Bergholtz L (1990) Otoneurological findings in workers exposed to styrene. Scand J Work Environ Health 16:189–194

    Article  PubMed  Google Scholar 

  27. Calabrese G, Martini A, Sessa G, Cellini M, Bartolucci GB, Marcuzzo G, De Rosa E (1996) Otoneurological study in workers exposed to styrene in the fiberglass industry. Int Arch Occup Environ Health 68:219–223

    Article  CAS  PubMed  Google Scholar 

  28. Larsby B, Tham R, Odkvist LM, Hydén D, Bunnfors I, Aschan G (1978) Exposure of rabbits to styrene. Electronystagmographic findings correlated to the styrene level in blood and cerebrospinal fluid. Scand J Work Environ Health 4:60–65

    Article  CAS  PubMed  Google Scholar 

  29. Niklasson M, Tham R, Larsby B, Eriksson B (1993) Effects of toluene, styrene, trichloroethylene, and trichloroethane on the vestibulo- and opto-oculo motor system in rats. Neurotoxicol Teratol 15:327–334

    Article  CAS  PubMed  Google Scholar 

  30. Odkvist LM, Larsby B, Tham R, Ahlfeldt H, Andersson B, Eriksson B, Liedgren SR (1982) Vestibulo-oculomotor disturbances in humans exposed to styrene. Acta Otolaryngol (Stockh) 94:487–493

    Article  CAS  Google Scholar 

  31. Ledin T, Odkvist LM, Möller C (1989) Posturography findings in workers exposed to industrial solvents. Acta Otolaryngol (Stockh) 107:357–361

    Article  CAS  Google Scholar 

  32. Zamyslowska-Szmytke E, Sliwinska-Kowalska M (2011) Vestibular and balance findings in nonsymptomatic workers exposed to styrene and dichloromethane. Int J Audiol 50:815–822

    Article  PubMed  Google Scholar 

  33. Cherry N, Rodgers B, Venables H, Waldron HA, Wells GG (1981) Acute behavioral effects of styrene exposure: a further analysis. Br J Ind Med 38:346–350

    CAS  PubMed Central  PubMed  Google Scholar 

  34. Lindström K (1981) Behavioral changes after long-term exposure to organic solvents and their mixtures: determining factors and research results. Scand J Work Environ Health 7(Suppl 4):48–53

    PubMed  Google Scholar 

  35. Seeber A, Bruckner T, Triebig G (2009) Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurements. Int Arch Occup Environ Health 82:969–984

    Article  CAS  PubMed  Google Scholar 

  36. Cherry N, Waldron HA, Wells GG, Wilkinson RT, Wilson HK, Jones S (1980) An investigation of the acute behavioural effects of styrene on factory workers. Br J Ind Med 37:234–240

    CAS  PubMed Central  PubMed  Google Scholar 

  37. Flodin U, Ekberg K, Andersson L (1989) Neuropsychiatric effects of low exposure to styrene. Br J Ind Med 46:805–808

    CAS  PubMed Central  PubMed  Google Scholar 

  38. Triebig G, Lehrl S, Weltle D, Schaller KH, Valentin H (1989) Clinical and neurobehavioural study of the acute and chronic neurotoxicity of styrene. Br J Ind Med 46:799–804

    CAS  PubMed Central  PubMed  Google Scholar 

  39. Cherry N, Gautrin D (1990) Neurotoxic effects of styrene: further evidence. Br J Ind Med 47:29–37

    CAS  PubMed Central  PubMed  Google Scholar 

  40. Lilis R, Lorimer WV, Diamond S, Selikoff IJ (1978) Neurotoxicity of styrene in production and polymerization workers. Environ Res 15:133–138

    Article  CAS  PubMed  Google Scholar 

  41. Kishi R, Tozaki S, Gong YY (2000) Impairment of neurobehavioral function and color vision loss among workers exposed to low concentration of styrene–a review of literatures. Ind Health 38:120–126

    Article  CAS  PubMed  Google Scholar 

  42. Mutti A, Falzoi M, Romanelli A, Bocchi MC, Ferroni C, Franchini I (1988) Brain dopamine as a target for solvent toxicity: effects of some monocyclic aromatic hydrocarbons. Toxicology 49:77–82

    Article  CAS  PubMed  Google Scholar 

  43. Von Euler G, Bjørnaes S (1990) Persistent effects of chronic exposure to styrene on the affinity of neostriatal dopamine D-2 receptors. Toxicol Lett 54:101–106

    Article  Google Scholar 

  44. Gagnaire F, Chalansonnet M, Carabin N, Micillino J-C (2006) Effects of subchronic exposure to styrene on the extracellular and tissue levels of dopamine, serotonin and their metabolites in rat brain. Arch Toxicol 80:703–712

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

We thank Katie Ogston for copy-editing the manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. German Center for Vertigo and Balance Disorders, University Hospital Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany

    Carolin Simone Fischer, Otmar Bayer & Michael Strupp

  2. Department of Neurology, University Hospital Munich, Campus Grosshadern, Marchioninistrasse 15, 81377, Munich, Germany

    Michael Strupp

Authors
  1. Carolin Simone Fischer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Otmar Bayer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael Strupp
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolin Simone Fischer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fischer, C.S., Bayer, O. & Strupp, M. Transient bilateral vestibular dysfunction caused by intoxication with low doses of styrene. Eur Arch Otorhinolaryngol 271, 619–623 (2014). https://doi.org/10.1007/s00405-013-2819-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-013-2819-z

Keywords

Search

Navigation