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Donor egg IVF model to assess ecological implications for ART success

  • Assisted Reproduction Technologies
  • Published:
Journal of Assisted Reproduction and Genetics Aims and scope Submit manuscript

Abstract

Purpose

Environmental influences on reproductive success are recognized. We hypothesized that location of fertility clinics may influence treatment success and explored this hypothesis utilizing donor egg IVF (IVF) embryo transfer (ET) model.

Methods

Publicly accessible national registry data (Society for Assisted Reproductive Technology) on fresh & frozen (FET) ET cycles undertaken at participating clinics across North America (n = 444 IVF centers) for 2007 were utilized. Information on number of donor egg IVF cycles, live birth (LB) rate following fresh and frozen ET(FET), average number (#) of ET and IVF center's location, geographical coordinates (latitude, longitude, altitude), annualized average temperatures and midyear regional ultraviolet B (UVB) radiation intensity were obtained. Multivariable logistic regression analyses assessed relationship between LBR (in tertile and uppermost versus lesser quartiles) following fresh and FET with geographical coordinates (region and altitude of clinic location) and ecological influences (average temperature and midyear UVB intensity), adjusting for #ET and clinic experience with donor egg IVF.

Results

Average number of fresh ET, clinic location (region) and midyear UVB intensity were positive predictors of LBR following fresh ET, whereas altitude and annualized average regional temperature demonstrated an inverse relationship with LBR following fresh ET. For FET cycles, #ET, clinic region and altitude were positive determinants of increasing LBR’s. Annualized regional temperature and midyear UVB failed to demonstrate any relationship with LB following donor egg FET.

Conclusion

Our data suggest that ecological influences may relate to donor egg IVF cycle success. Future studies are needed to better elucidate the mechanisms that could explain the observed associations.

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References

  1. Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet. 1978;2(8085):366.

    Article  CAS  PubMed  Google Scholar 

  2. Center for disease control and prevention. Assisted reproductive technology success rates, 2008. National summary and fertility clinic reports [online]. URL: http://www.cdc.gov/art/ART2008/PDF/ART_2008_Full.pdf (Last accessed 25 Nov 2012).

  3. Ferraretti AP, Goossens V, de Mouzon J, Bhattacharya S, Castilla JA, Korsak V, et al. European IVF-monitoring (EIM); Consortium for European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Hum Reprod. 2012;27(9):2571–84.

    Article  CAS  PubMed  Google Scholar 

  4. Wang J, Sauer MV. In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement. Ther Clin Risk Manag. 2006;2(4):355–64.

    Article  PubMed Central  PubMed  Google Scholar 

  5. The Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology. Recommendations for gamete and embryo donation: a committee opinion. Fertil Steril. 2012 Oct 17.

  6. Society for Assisted Reproductive Technology. http://sart.org/find_frm.html. (Last accessed 25 Nov 2012).

  7. Borini A, Suriano R, Barberi M, Dal Prato L, Bulletti C. Oocyte donation programs: strategy for improving results. Ann N Y Acad Sci. 2011;1221:27–31.

    Article  PubMed  Google Scholar 

  8. Noyes N, Hampton BS, Berkeley A, Licciardi F, Grifo J, Krey L. Factors useful in predicting the success of oocyte donation: a 3-year retrospective study. Fertil Steril. 2001;76:92–7.

    Article  CAS  PubMed  Google Scholar 

  9. Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, et al. Clinical factors affecting endometrial receptiveness in oocyte donation cycles. Fertil Steril. 2008;89(3):491–501.

    Article  PubMed  Google Scholar 

  10. Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82(4):850–6.

    Article  PubMed  Google Scholar 

  11. Briggs D. Environmental pollution and the global burden of disease. Br Med Bull. 2003;68:1–24.

    Article  CAS  PubMed  Google Scholar 

  12. Grant WB. A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries. Dermatoendocrinol. 2011;3(3):193–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Grant WB, Cannell JJ. Autism prevalence in the United States with respect to solar ultraviolet-B doses: An ecological study. Dermato-endocrinology. 2013;5:159–64.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Guillette Jr LJ, Iguchi T. Ecology. Life in a contaminated world. Science. 2012;337(6102):1614–5.

    Article  PubMed  Google Scholar 

  15. Sloka S, Silva C, Pryse-Phillips W, Patten S, Metz L, Yong VW. A quantitative analysis of suspected environmental causes of MS. Can J Neurol Sci. 2011;38(1):98–105.

    PubMed  Google Scholar 

  16. Bronson FH. Mammalian reproduction: an ecological perspective. Biol Reprod. 1985;32(1):1–26.

    Article  CAS  PubMed  Google Scholar 

  17. Legro RS, Sauer MV, Mottla GL, Richter KS, Li X, Dodson WC, et al. Effect of air quality on assisted human reproduction. Hum Reprod. 2010;25(5):1317–24.

    Article  PubMed  Google Scholar 

  18. Gillie O. The Scots' Paradox: can sun exposure, or lack of it, explain major paradoxes in epidemiology? Anticancer Res. 2012;32:237–48.

    CAS  PubMed  Google Scholar 

  19. Cummings DR. Human birth seasonality and sunshine. Am J Hum Biol. 2010;22(3):316–24.

    Article  PubMed  Google Scholar 

  20. Cummings DR. Seasonal sunshine and vitamin D: a possible explanation for differences in European and United States birth patterns. Biodemography Soc Biol. 2010;56(2):105–22.

    Article  PubMed  Google Scholar 

  21. Stumpf WE, Denny ME. Vitamin D (soltriol), light, and reproduction. Am J Obstet Gynecol. 1989;161(5):1375–84. Review.

    Article  CAS  PubMed  Google Scholar 

  22. Luk J, Torrealday S, Neal Perry G, Pal L. Relevance of vitamin D in reproduction. Hum Reprod. 2012;27(10):3015–27.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010;94(4):1314–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27(11):3321–7.

    Article  CAS  PubMed  Google Scholar 

  25. Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101:447–52.

    Article  CAS  PubMed  Google Scholar 

  26. Anifandis GM, Dafopoulos K, Messini CI, Chalvatzas N, Liakos N, Pournaras S, et al. Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome. Reprod Biol Endocrinol. 2010;8:91.

    Article  PubMed Central  PubMed  Google Scholar 

  27. Canto MT, Anderson WF, Brawley O. Geographic variation in breast cancer mortality for white and black women: 1986-1995. CA Cancer J Clin. 2001;51(6):367–70.

    Article  CAS  PubMed  Google Scholar 

  28. Elliott JC, Lucas RM, Clements MS, Bambrick HJ. Population density determines the direction of the association between ambient ultraviolet radiation and type 1 diabetes incidence. Pediatr Diabetes. 2010;11(6):394–402.

    Article  PubMed  Google Scholar 

  29. Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006;26(4A):2687–99.

    CAS  PubMed  Google Scholar 

  30. Grant WB. Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Res. 2012;32(1):223–36.

    CAS  PubMed  Google Scholar 

  31. Milo R, Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev. 2010;9(5):A387–94.

    Article  CAS  PubMed  Google Scholar 

  32. Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008;51(8):1391–8.

    Article  CAS  PubMed  Google Scholar 

  33. Sariego J. Patterns of breast cancer presentation in the United States: does geography matter? Am Surg. 2009;75(7):545–9.

    PubMed  Google Scholar 

  34. Sturgeon SR, Schairer C, Gail M, McAdams M, Brinton LA, Hoover RN. Geographic variation in mortality from breast cancer among white women in the United States. J Natl Cancer Inst. 1995;87(24):1846–53.

    Article  CAS  PubMed  Google Scholar 

  35. Wei-Passanese EX, Han J, Lin W, Li T, Laden F, Qureshi AA. Geographical variation in residence and risk of multiple nonmelanoma skin cancers in US women and men. Photochem Photobiol. 2012;88(2):483–9.

    Article  CAS  PubMed  Google Scholar 

  36. Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005;10(2):94–111. Review.

    PubMed  Google Scholar 

  37. United States Census Bureau, Census Bureau Regions and Divisions with State FIPC Codes. http://www.census.gov/geo/www/us_regdiv.pdf (last accessed 25 Nov 2012).

  38. http://www.wunderground.com/wundermap/, (last accessed 25 Nov 2012).

  39. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80(6):1678S–88.

    CAS  PubMed  Google Scholar 

  40. United States Environmental Protection Agency, Monthly UV Index. http://www.epa.gov/sunwise/uvimonth.html (last accessed 25 Nov 2012).

  41. Grubesic TH, Matisziw TC. On the use of ZIP codes and ZIP code tabulation areas (ZCTAs) for the spatial analysis of epidemiological data. Int J Health Geogr. 2006;5:58.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Hibbert JD, Liese AD, Lawson A, Porter DE, Puett RC, Standiford D, et al. Evaluating geographic imputation approaches for zip code level data: an application to a study of pediatric diabetes. Int J Health Geogr. 2009;8:54.

    Article  PubMed Central  PubMed  Google Scholar 

  43. Du H, Daftary GS, Lalwani SI, Taylor HS. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol. 2005;19:2222–33.

    Article  CAS  PubMed  Google Scholar 

  44. Evans KN, Nguyen L, Chan J, Innes BA, Bulmer JN, Kilby MD, et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod. 2006;75(6):816–22.

    Article  CAS  PubMed  Google Scholar 

  45. Tavakoli M, Jeddi-Tehrani M, Salek-Moghaddam A, Rajaei S, Mohammadzadeh A, Sheikhhasani S, et al. Effect of 1,25(OH)(2) vitamin D(3) on cytokine production by endometrial cells of women with repeated implantation failure. Gynecol Endocrinol. 2012;28:906–11.

    Article  PubMed  Google Scholar 

  46. Lam DA, Miron JA. Seasonality of births in human populations. Soc Biol. 1991;3:51–78.

    Google Scholar 

  47. Wood S, Quinn A, Troupe S, Kingsland C, Lewis-Jones I. Seasonal variation in assisted conception cycles and the influence of photoperiodism on outcome in in vitro fertilization cycles. Hum Fertil (Camb). 2006;9(4):223–9.

    Article  Google Scholar 

  48. Barber N. On the Relationship Between Fertility and Geographic Latitude: A Cross-National Study. Cross-Cult Res. 2002;36:3–15.

    Article  Google Scholar 

  49. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96(2):344–8.

    Article  PubMed  Google Scholar 

  50. Rybak EA, Bevilacqua K, Veit CR, Klugman SD, Santoro N. Sibling and self ovum donation for sisters with an intermediate FMR1 mutation: what's a program to do? Fertil Steril. 2009;92:394.e9–394.e12.

    Google Scholar 

  51. Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J, Meseguer M. Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril. 2013;100:1050–8.

    Article  PubMed  Google Scholar 

  52. Sunkara SK, Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 2010;25:418–29.

    Article  PubMed  Google Scholar 

  53. Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82:850–6.

    Article  PubMed  Google Scholar 

  54. Cohen MA, Lindheim SR, Sauer MV. Hydrosalpinges adversely affect implantation in donor oocyte cycles. Hum Reprod. 1999;14:1087–9.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, FMB329, New Haven, CT, 06510, USA

    Lubna Pal

  2. University of Connecticut Storrs, Storrs, CT, USA

    Neiha Kidwai & Jehanzeb Kayani

  3. Sunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA, 94164-1603, USA

    William B. Grant

Authors
  1. Lubna Pal
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  2. Neiha Kidwai
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Correspondence to Lubna Pal.

Additional information

Capsule Within North American, geographical location of fertility clinic relates to donor egg IVF success.

These data were presented as an abstract at the 69th annual meeting of American Society for Reproductive Medicine, October 2012, San Diego.

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ESM 1

UV Outlook Index (a measure of summertime solar UVB) across North America (United States Environmental Protection Agency, http://www.epa.gov/sunwise/uvimonth.html [40], last accessed 2/3/14). (JPEG 92 kb)

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Pal, L., Kidwai, N., Kayani, J. et al. Donor egg IVF model to assess ecological implications for ART success. J Assist Reprod Genet 31, 1453–1460 (2014). https://doi.org/10.1007/s10815-014-0322-0

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  • DOI: https://doi.org/10.1007/s10815-014-0322-0

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