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Peripheral T-cell lymphoma with involvement of the expanded mantle zone

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Abstract

Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they represent a separate T-cell lymphoma type remains to be demonstrated by a study of more of such cases.

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Authors and Affiliations

  1. Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway

    Ida Münster Ikonomou, Anne Tierens, Gunhild Troen, Helen Vålerhaugen & Jan Delabie

  2. Department of Cancer Genetics, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway

    Hege Vangstein Aamot & Sverre Heim

  3. Department of Oncology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway

    Grete F. Lauritzsen

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  1. Ida Münster Ikonomou
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  2. Anne Tierens
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Correspondence to Ida Münster Ikonomou.

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Ikonomou, I.M., Tierens, A., Troen, G. et al. Peripheral T-cell lymphoma with involvement of the expanded mantle zone. Virchows Arch 449, 78–87 (2006). https://doi.org/10.1007/s00428-005-0123-z

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  • DOI: https://doi.org/10.1007/s00428-005-0123-z

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