Abstract
This study tested the hypothesis that sildenafil daily for 1 year can cure vascular erectile dysfunction (ED). In a prospective, randomized controlled trial, patients were assigned to two groups: group I, 50 mg of sildenafil daily at bedtime; group II, 50 to 100 mg of sildenafil on demand. The primary efficacy measures were International Index of Erectile Function domain score and peak systolic velocity (PSV) of penile arteries after treatment and following the nonmedicated periods. Treatment with 50 mg daily sildenafil for 1 year resulted in enduring normalization of erectile function in 59% of patients and a PSV of the cavernous arteries improved from 29.4 ± 9.8 cm/sec to 38.9 ± 10.3 cm/sec (P < 0.05). Sildenafil taken daily for 1 year resulted in ED regression and may be a useful tool for curing ED.
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Feldmann HA, Goldstein I, Hatzichristou DG, et al.: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994, 151:54–61.
Aytac IA, McKinlay JB, Krane RJ: The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999, 84:50–56.
Christiansen E, Guirguis WR, Cox D, Osterloh IH: Long-term efficacy and safety of oral Viagra (sildenafil citrate) in men with erectile dysfunction and the effect of randomised treatment withdrawal. Int J Impot Res 2000, 12:177–182.
Saenz de Tejada I, Gonzales Cadavid N, et al.: Anatomy, physiology and pathophysiology of erectile dysfunction. In Erectile Dysfunction. Edited by Jardin A, Wagner G, Khoury S, Giuliano F, Padma-Nathan H, Rosen RC. Plymouth: Health Publications; 2000:65–102.
Terradas C, Levalle O, Nagelberg A, Mormandi E: Sildenafil improves nocturnal penile erections in organic impotence. Int J Impot Res 2001, 13:125–129.
Halcox JP, Nour KR, Zalos G, et al.: The effect of sildenafil on human vascular function, platelet activation, and myocardial ischemia. J Am Coll Cardiol 2002, 40:1232–1240.
Karacan I, Hursch CJ, Williams RL: Some characteristics of nocturnal penile tumescence in elderly males. J Gerontol 1972, 27:39–45.
Desouza C, Parulkar A, Lumpkin D, et al.: Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 2002, 25:1336–1339.
Montorsi F, Maga T, Strambi LF, et al.: Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study. Urology 2000, 56:906–911.
Rochira V, Granata AR, Balestrieri A, et al.: Effects of sildenafil on nocturnal penile tumescence and rigidity in normal men: randomized, placebo-controlled, crossover study. J Androl 2002, 23:566–571.
Rosen RC, Riley A, Wagner G, et al.: The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49:822–830.
Cappelleri JC, Rosen RC, Smith MD, et al.: Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999, 54:346–351.
Jünemann KP, Siegsmund M, Lobelenz M, Alken P: Dopplersonographie der penisarterien. Urologe A 1990, 29:113–119.
Jünemann KP, Siegsmund M, Lobelenz M, Alken P: Ultrasound evaluation of the penis for assessment of impotence. J Clin Ultrasound 1996, 24:481–486.
Ornish D, Brown SE, Scherwitz LW, et al.: Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet 1990, 336:129–133.
Porst H, van Ahlen H: Stellenwert nächtlicher peniler Tumeszenz- und rigiditätsmessungen (NPT) mit dem Rigiscan(r) bei erektiler Dysfunktion. Aktuel Urol 1988, 19:21–25.
Kim N, Vardi Y, Padma-Nathan H, et al.: Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J Clin Invest 1993, 91:437–442.
Nehra A, Gettman MT, Nugent M, et al.: Transforming growth factor-beta1 (TGF-beta1) is sufficient to induce fibrosis of rabbit corpus cavernosum in vivo. J Urol 1999, 162(3 Pt1):910–915.
Katz SD, Balidemaj K, Homma S, et al.: Acute type 5 phosphodiesterase inhibition with sildenafil enhances flowmediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol 2000, 36:845–851.
Pallas J, Levine SB, Althof SE, Risen CB: A study using Viagra in a mental health practice. J Sex Marital Ther 2000, 26:41–50.
Wagner G: Erection: anatomy. In Impotence, Physiological, Psychological, Surgical, Diagnosis and Treatment. Edited by Wagner G, Green R. New York: Plenum Press; 1981:7–24.
Lerner SE, Melman A, Christ GJ: A review of erectile dysfunction: new insights and more questions. J Urol 1993, 149(5 Pt 2):1246–1255.
Mersdorf A, Goldsmith PC, Diederichs W, et al.: Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J Urol 1991, 145:749–758.
Krane RJ, Goldstein I, Saenz de Tejada I: Impotence. N Engl J Med 1989, 321:1648–1659.
Moreland RB: Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 1998, 10:113–120.
Montorsi F, Guazzoni G, Strambi LF, et al.: Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 1997, 158:1408–1410.
Moreland RB, Traish A, McMillin MA, et al.: PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol 1995, 153(3 Pt 1):826–834.
Border WA, Ruoslahti E: Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest 1992, 90:1–7.
Lawrence R, Hartmann DJ, Sonenshein GE: Transforming growth factor beta 1 stimulates type V collagen expression in bovine vascular smooth muscle cells. J Biol Chem 1994, 269:9603–9609.
Sommer F, Peters C, Klotz T, et al.: Sport und Bewegung in der Prävention Urologischer Erkrankungen. Urologe 2002, 42:297–305.
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Sommer, F. Curing erectile dysfunction: Pro. Current Sexual Health Reports 2, 48–50 (2005). https://doi.org/10.1007/s11930-005-0003-1
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DOI: https://doi.org/10.1007/s11930-005-0003-1