Skip to main content

Advertisement

SpringerLink
Log in

A Critical assessment of extracorporeal shock-wave therapy for Peyronie’s disease

  • Published:
Current Sexual Health Reports Aims and scope Submit manuscript

Abstract

Standardization of the procedure of extracorporeal shockwave therapy (ESWT) is currently lacking. Although some positive results in terms of improvement of penile pain, penile curvature, and overall subjective symptoms have been reported, evidence-based data are lacking. ESWT seems to be well tolerated, but longer follow-up is needed to exclude possible long-term side effects. There is no clear explanation of the mechanism of action of ESWT in patients with Peyronie’s disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References and Recommended Reading

  1. Briganti A, Salonia A, Dehò F, et al.: Peyronie’s disease: a review. Curr Opin Urol 2003, 13:417–422.

    Article  PubMed  Google Scholar 

  2. Lindsay MB, Shain DM, Grambsch P, et al.: The incidence of Peyronie’s disease in Rochester, Minnesota, 1950 through 1984. J Urol 1991, 146:1007–1009.

    PubMed  CAS  Google Scholar 

  3. Smith BH: Subclinical Peyronie’s disease. Am J Clin Pathol 1969, 52:385–390.

    PubMed  CAS  Google Scholar 

  4. Butz M, Teichert HM: Treatment of Peyronie’s disease by extracorporeal shock waves. Proceedings of the American Urological Association [abstract]. J Urol 1998, 159:118.

    Google Scholar 

  5. Lingeman JE, McAteer JA, Kempson SA, et al.: Bioeffects of extra-corporeal shock wave lithotripsy: strategy for research and treatment. Urol Clin North Am 1998, 15:505–514.

    Google Scholar 

  6. Haupt G, Chapril M: Effect of shockwaves on the healing of partial thickness wounds in piglets. J Surg Res 1990, 49:45–48.

    Article  PubMed  CAS  Google Scholar 

  7. Levine LA: Review of current nonsurgical management of Peyronie’s disease. Int J Impot Res 2003, 15:S113-S120. This excellent paper is a critical review of the current nonsurgical treatment options for Peyronie’s disease, including oral, intralesional, topical, external energy, and combination therapies, often associated with discordant results.

    Article  PubMed  Google Scholar 

  8. Mulhall JP: Deciphering erectile dysfunction drug trials. J Urol 2003, 170:353–358. This comprehensive review of the literature highlights the major points that should be analyzed during erectile dysfunction drug trials, such as trial design, patient population studied, end points used, and adverse events profile.

    Article  PubMed  Google Scholar 

  9. Hauck EW, Altinkilic BM, Ludwig M, et al.: Extracorporeal shock wave therapy in the treatment of Peyronie’s disease. Eur Urol 2000, 38:663–670. A report of the first preliminary results of a case-controlled approach to assess the efficacy and safety of ESWT compared with placebo. The authors provide extensive data regarding the clinical ESWT profile and plaque size before and after treatment.

    Article  PubMed  CAS  Google Scholar 

  10. Hauck EW, Hauptmann A, Bschleipfer T, et al.: Questionable efficacy of extracorporeal shock wave therapy for Peyronie’s disease: results of a prospective approach. J Urol 2004, 171:296–299.

    Article  PubMed  Google Scholar 

  11. Mirone V, Imbimbo C, Palmieri A, et al.: Our experience of the association of a new physical and medical therapy in patients suffering from induratio penis plastica. Eur Urol 1999, 36:327–330.

    Article  PubMed  CAS  Google Scholar 

  12. Michel MS, Braun P, Sazova O, et al.: Shock wave therapy for the treatment of Peyronie’s diasease: first clinical investigation for the objective determination of deviation improvement by means of artificial erection. Proceedings of the American Urological Association [abstract]. J Urol 1999, 161:262.

    Article  Google Scholar 

  13. Lebret T, Loison G, Hervè JM, et al.: Extracorporeal shock wave therapy in the treatment of Peyronie’s disease: experience with standard lithotriptor (Siemens-Multiline). Urology 2002, 59:657–661.

    Article  PubMed  Google Scholar 

  14. Manikandan R, Islam W, Srinivasan V, et al.: Evaluation of extracorporeal shock wave therapy in Peyronie’s disease. Urology 2002, 60:795–799. Although many variables can limit the correct interpretation of these results, randomization of patients to different timings of ESWT is an interesting tool for the eventual development of a standardized protocol for ESWT in patients affected by Peyronie’s disease.

    Article  PubMed  CAS  Google Scholar 

  15. Lebret T, Herve JM, Lugagne PM, et al.: Extra-corporeal lithotripsy in the treatment of Peyronie’s disease. Use of a standard lithotriptor (Multiline Siemens) on ‘young’ (less than six months) plaque. Prog Urol 2000, 10:65–71.

    PubMed  CAS  Google Scholar 

  16. Sytenko A: Shock wave therapy of Peyronie’s disease: Does correction depend on energy level? Proceedings of the European Society for Sexual Medicin [abstract]. Int J Impot Res 2003, 15:S54.

    Google Scholar 

  17. Hamm R, Mclarty E, Ashdown J, et al.: Peyronie’s disease: the Plymouth experience of extracorporeal shockwave treatment. BJU Int 2001, 87:849–852. Although few patients were enrolled in this study, the authors objectively assessed patients before and after treatment with a validated questionnaire (IIEF) and performed artificial, assisted erection and penile ultrasonography in all patients.

    Article  PubMed  CAS  Google Scholar 

  18. Husain J, Lynn NNK, Jones DK, et al.: Extracorporeal shock wave therapy in the management of Peyronie’s disease: initial experience. BJU Int 2000, 86:466–468.

    Article  PubMed  CAS  Google Scholar 

  19. Gianneo E, Nespoli R, Conti G, et al.: La Peyronie’s disease (IPP) and extracorporeal shock waves therapy (ESWT): our experience. Proceedings of the American Urological Association [abstract]. J Urol 1998, 161:205.

    Google Scholar 

  20. Colombo F, Serrago M, Esposito N, et al.: Shock waves in Peyronie’s disease: the preliminary report. Proceedings of the American Urological Association [abstract]. J Urol 1998, 159:119.

    Article  Google Scholar 

  21. Colombo F, Mantovani F, Patelli E, et al.: Shock waves in la Peyronie’s disease: two-year experience. Proceedings of the European Association of Urology [abstract]. Eur Urol 1999, 35:124. This abstract is one of the first reports of ESWT as an effective therapy for Peyronie’s disease. Based on the large number of patients enrolled, the authors interestingly underlined how penile plaque features (such as calcifications) should be associated with different timing and modality of application of ESWT in patients affected by Peyronie’s disease.

    Google Scholar 

  22. Sautter T, Bangerter U, Sulser T: Extracorporeal shock wave (ESW) as a new effective treatment in Peyronie’s disease. Proceedings of the European Association of Urology [abstract]. Eur Urol 1999, 35:124.

    Google Scholar 

  23. Baumann M, Tauber R: Induratio penis plastica: extrakorporale piezoelektrische Stoss-wellentherapie als neuer Therapieansatz. Akt Urol 1998, 29:1–5.

    Google Scholar 

  24. Kiyota H, Ohishi Y, Asano K, et al.: Extracorporeal shock wave treatment for Peyronie’s disease using EDAP LT-02: preliminary results. Int J Urol 2002, 9:110–113.

    Article  PubMed  Google Scholar 

  25. Abdel-Salm Y, Budair Z, Renner C, et al.: Treatment of Peyronie’s disease by extracorporeal shockwave therapy: evaluation of our preliminary results. J Endourol 1999, 13:549–552.

    Article  Google Scholar 

  26. Gelbard MK, Dorey F, James K: The natural history of Peyronie’s disease. J Urol 1990, 144:1376–1379.

    PubMed  CAS  Google Scholar 

  27. Rosen RC, Riley A, Wagner G, et al.: The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997, 54:346–351.

    Google Scholar 

  28. Gelbard MK, Dorey F, James K: The natural history of Peyronie’s disease. J Urol 1990, 144:1376–1379.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Urology, Università Vita Salute San Raffaele, Via Olgettina 60, 20132, Milano, Italy

    Alberto Briganti MD, Andrea Salonia MD, Giuseppe Zanni MD, Federico Dehò MD, Nazareno Suardi MD, Bruno Mazzoccoli MD, Vincenzo Scattoni MD & Francesco Montorsi MD

Authors
  1. Alberto Briganti MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Salonia MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Giuseppe Zanni MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Federico Dehò MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Nazareno Suardi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bruno Mazzoccoli MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vincenzo Scattoni MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Francesco Montorsi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Briganti, A., Salonia, A., Zanni, G. et al. A Critical assessment of extracorporeal shock-wave therapy for Peyronie’s disease. Curr sex health rep 1, 19–23 (2004). https://doi.org/10.1007/s11930-004-0014-3

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11930-004-0014-3

Keywords

Search

Navigation