Abstract
The infrared transmission spectrum has been studied on the mixed medicine sample composed of sildenafil citrate (SDF or Viagra) and traditional Chinese medicine(TCM). The measured infrared spectra are composed of several broad absorption bands and many sharp absorption lines. Then the broad absorption bands are changed from sample to sample. It is identified that the sharp and broad absorption bands are from the Viagra and TCM, respectively. A numerical best fitting process has been used to extract the absorption spectrum from the spectrum of mixed sample. Combined with the numerical analysis, the Viagra component can be extracted from the mixed material even with a changeable broad absorption bands' background. It shows that the infrared transmission spectroscopy is a useful method to extract the component of chemical medicine from the mixed medicine.
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Reference
http//www.fda.gov/cder/consumerinfo/viagra/viagra update 721.htm, July 22 (1998).
Kazzahiro saisho, Karen S, Scott, Shigeyoshi Morimoto, and Yuji Nakahara, Biol, Pharm, Bull, 24(12)1384-1388(2001).
Qiming Zhang, Hua Ying, Hau[wev Huang, Weihua Zhu and Ruying Yu, Joural of Medicine Analysis (in chinese) 22(4).315-317 (2002).
W. Lu, W. L. Xu, X. C. Shen, 1996, "Localization effect on the frequency of impurity local modes in a semiconductor", J. Phys. Chem. Solids, 57, 643(1996)
W. Lu, Y.M. Mu, S.C. Shen, Y. Fu, and M. Willander, International Jounal of Infrared & Millimeter Waves, 19, 1007(1998)
Liu P. Xu WL. Lu W, International Journal of Infrared & Millimeter Waves. 22, 469, (2001)
Z.F. Li, W. Lu, S.C. Shen, S. Holland, C.M. Hu, D. Hetmann, B. Shen, Y.D. Zheng, T. Someya, Y. Arakawa, Appl. Phys. Lett. 80, 431, (2002)
Cooper J D H, Mairhead D C, Taylor J E, Baker P R, J. Chromatogr. B, 701 87-95 (1997).
Jeong C K, Lee H Y, Jang M S, Kim W B, Lee H S, ibid., 754 141-147 (2001).
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Wang, Y., Chen, G., Zhu, Z. et al. Study on Infrared Transmission Spectrum of Sildenafil Citrate Mixed in Traditional Chinese Medicine. International Journal of Infrared and Millimeter Waves 24, 1177–1185 (2003). https://doi.org/10.1023/A:1024725220089
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DOI: https://doi.org/10.1023/A:1024725220089