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Myelodysplastic syndromes: Their history, evolution and relation to acute myeloid leukaemia

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Summary

The myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal disorders arising from a multipotent haemopoietic progenitor which share a leukaemic propensity, 30% of cases culminating in acute myeloid leukaemia (AML). Their pathogenesis probably entails multiple steps, phenotypic progression being determined by either expansion or evolution of the abnormal clone. The clonal origin of certain cases of de novo AML is analogous to that of MDS and evidence that they share a common pathogenesis and distinct biological characteristics is beginning to emerge.

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  1. Department of Haematology, King's College Hospital, School of Medicine and Dentistry, Denmark Hill, SE 5 8 RX, London, UK

    D. M. Layton & G. J. Mufti

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D. M. Layton is supported by a grant from the Leukaemia Research Fund.

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Layton, D.M., Mufti, G.J. Myelodysplastic syndromes: Their history, evolution and relation to acute myeloid leukaemia. Blut 53, 423–436 (1986). https://doi.org/10.1007/BF00320305

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