Abstract
Human evolution has shaped gender differences between males and females. Over the years, scientific studies have proposed that epigenetic modifications significantly influence sex-specific differences. The evolution of sex chromosomes with epigenetics as the driving force may have led to one sex being more adaptable than the other when exposed to various factors over time. Identifying and understanding sex-specific differences, particularly in DNA methylation, will help determine how each gender responds to factors, such as disease susceptibility, environmental exposure, brain development and neurodegeneration. From a medicine and health standpoint, sex-specific methylation studies have shed light on human disease severity, progression, and response to therapeutic intervention. Interesting findings in gender incongruent individuals highlight the role of genetic makeup in influencing DNA methylation differences. Sex-specific DNA methylation studies will empower the biotechnology and pharmaceutical industry with more knowledge to identify biomarkers, design and develop sex bias drugs leading to better treatment in men and women based on their response to different diseases.
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This work was supported by the National Research Foundation of South Africa (Grant Number: 130674).
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Govender, P., Ghai, M. & Okpeku, M. Sex-specific DNA methylation: impact on human health and development. Mol Genet Genomics 297, 1451–1466 (2022). https://doi.org/10.1007/s00438-022-01935-w
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DOI: https://doi.org/10.1007/s00438-022-01935-w