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Universal MRSA/Staphylococcal Decolonization for Hospitalized Patients

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Infection Prevention

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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) remains an important public health threat. MRSA is one of the most important common causes of healthcare-associated infections (HAIs) in most hospitals. 47.9% of Staphylococcus aureus HAIs are due to MRSA. In addition, MRSA infections can result in substantial morbidity and mortality and lead to increase costs and length of stay. Both targeted decolonization, i.e., decolonize only patients identified to carry MRSA with chlorhexidine (CHG) bathing and intranasal mupirocin, and universal decolonization, i.e., decolonize all high-risk patients with CHG with or without mupirocin, have demonstrated decreased cross-transmission and infection with MRSA. Trials have shown that universal decolonization in adult and pediatric intensive care units (ICUs) has resulted in greater reduction of MRSA infections compared to targeted decolonization. A recent trial demonstrated universal decolonization with CHG bathing in non-critical care-reduced MRSA for patients with medical devices.

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Authors and Affiliations

  1. Department of Population Medicine, Harvard Medical School, Boston, MA, USA

    Edward J. Septimus

  2. Internal Medicine, Texas A&M College of Medicine, Houston, TX, USA

    Edward J. Septimus

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Editors and Affiliations

  1. VCUHS Epidemiology and Infection Control, Virginia Commonwealth University, Richmond, VA, USA

    Gonzalo Bearman

  2. Baltimore VA Medical Center, University of Maryland School of Medicine, Baltimore, MD, USA

    Daniel J. Morgan

  3. Division of Infectious Diseases, Cedars-Sinai, UCLA David Geffen School of Medicine, Los Angeles, CA, USA

    Rekha K. Murthy

  4. Infection Prevention and Control Department, University Health Network, Toronto, ON, Canada

    Susy Hota

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Septimus, E.J. (2022). Universal MRSA/Staphylococcal Decolonization for Hospitalized Patients. In: Bearman, G., Morgan, D.J., K. Murthy, R., Hota, S. (eds) Infection Prevention. Springer, Cham. https://doi.org/10.1007/978-3-030-98427-4_9

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