Zusammenfassung
Frauen mit einem erhöhten BMI gelten als Risikoschwangere sowohl hinsichtlich mütterlicher Komplikationen als auch in Bezug auf fetal-neonatale Risiken. Die signifikant erhöhte Prävalenz hypertensiver Schwangerschaftserkrankungen bei adipösen Frauen konnte in zahlreichen Studien belegt werden. Darüber hinaus ist eine maternale Adipositas nachweislich ein unabhängiger Risikofaktor für die Entstehung eines manifesten Gestationsdiabetes. Für beide Entitäten sind erhöhte Inzidenzraten für kongenitale Malformationen beschrieben worden, was letztlich unterstreicht, dass gerade adipöse Gestationsdiabetikerinnen ein besonderes Risikokollektiv von Schwangeren darstellen und impliziert folglich, dass bei diesen Schwangeren bereits frühzeitig Screening-Untersuchungen angeboten werden sollten. Auf die Detektionsraten fetaler Anomalien und die eingeschränkte Visualisierung fetaler Zielstrukturen im Rahmen der pränatalen sonografischen Diagnostik soll in diesem Kapitel explizit eingegangen werden.
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Literatur
Aagaard-Tillery KM, Flint Porter T, Malone FD et al (2010) Influence of maternal BMI on genetic sonography in the FaSTER trial. Prenat Diagn 30:14–22
Abenhaim HA, Kinch RA, Morin L et al (2007) Effect of prepregnancy body mass index categories on obstetrical and neonatal outcomes. Arch Gynecol Obstet 275:39–43
ACOG Committee Opinion No. 600 (2014) Ethical issues in the care of the obese woman. Obstet Gynecol 123(6):1388–1393
ACOG Committee Opinion No. 640 (2015) Cell-free DNA screening for fetal aneuploidy. Obstet Gynecol 126(3):e31–e37
ACOG Practice Bulletin No 156 (2015) Obesity in pregnancy. Obstet Gynecol 126(6):e112–e126
Adekola H, Soto E, Dai J, Lam-Rachlin J, Gill N, Leon-Peters J, Puder K, Abramowicz JS (2015) Optimal visualization of the fetal four-chamber and outflow tract views with transabdominal ultrasound in the morbidly obese: are we there yet? J Clin Ultrasound 43(9):548–555
Aksoy H, Aksoy Ü, Karadağ Öİ, Yücel B, Aydın T, Babayiğit MA (2015) Influence of maternal body mass index on sonographic fetal weight estimation prior to scheduled delivery. J Obstet Gynaecol Res 41(10):1556–1561
Al-Obaidly S, Al-Ibrahim A, Saleh N, Al-Belushi M, Al-Mansouri Z, Khenyab N (2017) Third trimester ultrasound accuracy and delivery outcome in obese and morbid obese pregnant women. J Matern Fetal Neonatal Med 32(8):1275–1279
Aly JM, Polotsky AJ (2017) Paternal diet and obesity: effects on reproduction. Semin Reprod Med 35(4):313–317
Artieri CG, Haverty C, Evans EA, Goldberg JD, Haque IS, Yaron Y, Muzzey D (2017) Noninvasive prenatal screening at low fetal fraction: comparing whole-genome sequencing and single-nucleotide polymorphism methods. Prenat Diagn 37(5):482–490
Ashoor G, Syngelaki A, Poon LC, Rezende JC, Nicolaides KH (2013) Fetal fraction in maternal plasma cell-free DNA at 11-13 weeks’ gestation: relation to maternal and fetal characteristics. Ultrasound Obstet Gynecol 41(1):26–32
Audibert F, De Bie I, Johnson JA, Okun N, Wilson RD, Armour C, Chitayat D, Kim R (2017) No. 348-Joint SOGC-CCMG guideline: update on prenatal screening for fetal aneuploidy, fetal anomalies, and adverse pregnancy outcomes. J Obstet Gynaecol Can 39(9):805–817
Aune D, Saugstad OD, Henriksen T, Tonstad S (2014) Maternal body mass index and the risk of fetal death, stillbirth, and infant death: a systematic review and meta-analysis. JAMA 311(15):1536–1546
Aviram A, Yogev Y, Ashwal E, Hiersch L, Hadar E, Gabbay-Benziv R (2017) Prediction of large for gestational age by various sonographic fetal weight estimation formulas-which should we use? J Perinatol 37(5):513–517
Bak GS, Sperling L, Källén K, Salvesen KÅ (2016) Prospective population-based cohort study of maternal obesity as a source of error in gestational age estimation at 11–14 weeks. Acta Obstet Gynecol Scand 95(11):1281–1287
Barber C, Rankin J, Heslehurst N (2017) Maternal body mass index and access to antenatal care: a retrospective analysis of 619,502 births in England. BMC Pregnancy Childbirth 17(1):290
Benacerraf B (2013) The use of obstetrical ultrasound in the obese gravida. Semin Perinatol 37(5):345–347
Benn P, Valenti E, Shah S, Martin K, Demko Z (2018) Factors associated with informative redraw after an initial no result in noninvasive prenatal testing. Obstet Gynecol 132(2):428–435
Bodnar LM, Ness RB, Markovic N et al (2005) The risk of preeclampsia rises with increasing prepregnancy body mass index. Ann Epidemiol 15:475–482
Boney CM, Verma A, Tucker R, Vohr BR (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115(3):e290–e296
Boots CE, Bernardi LA, Stephenson MD (2014) Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss. Fertil Steril 102(2):455–459
Broughton DE, Moley KH (2017) Obesity and female infertility: potential mediators of obesity’s impact. Fertil Steril 107(4):840–847
Cai GJ, Sun XX, Zhang L, Hong Q (2014) Association between maternal body mass index and congenital heart defects in offspring: a systematic review. Am J Obstet Gynecol 211(2):91–117
Callaway LK, Prins JB, Chang AM et al (2006) The prevalence and impact of overweight and obesity in an Australian obstetric population. Med J Aust 184:56–59
Canick JA, Palomaki GE, Kloza EM, Lambert-Messerlian GM, Haddow JE (2013) The impact of maternal plasma DNA fetal fraction on next generation sequencing tests for common fetal aneuploidies. Prenat Diagn 33(7):667–674
Catalano P, deMouzon SH (2015) Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes. Int J Obes 39(4):642–649
Catanzarite V, Delaney K, Wolfe S et al (2005) Targeted mid-trimester ultrasound examination: how does fetal anatomic visualization depend upon the duration of the scan? Ultrasound Obstet Gynecol 26:521–526
Centre for Maternal and Child Enquiries/Royal College of Obstetricians and Gynaecologists (2010) Management of women with obesity in pregnancy. https://www.rcog.org.uk/globalassets/documents/guidelines/cmacercogjointguidelinemanagementwomenobesitypregnancya.pdf. Zugegriffen am 30.06.2021
Chan WS, Rey E, Kent NE, VTE in Pregnancy Guideline Working Group, Chan WS, Kent NE, Rey E, Corbett T, David M, Douglas MJ, Gibson PS, Magee L, Rodger M, Smith RE, Society of Obstetricians and Gynecologists of Canada (2014) Venous thromboembolism and antithrombotic therapy in pregnancy. J Obstet Gynaecol Can 36(6):527–553
Chauhan SP, Henrichs CE (2003) Obesity in pregnancy: risks and interventions by gestational stage. OBG Management 15:27–38
Chiswick C, Reynolds RM, Denison F, Drake AJ, Forbes S, Newby DE, Walker BR, Quenby S, Wray S, Weeks A, Lashen H, Rodriguez A, Murray G, Whyte S, Norman JE (2015) Effect of metformin on maternal and fetal outcomes in obese pregnant women (EMPOWaR): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol 3(10):778–786
Chu SY, Kim SY, Lau J et al (2007) Maternal obesity and risk of stillbirth: a metaanalysis. Am J Obstet Gynecol 197:223–228
Chung JH, Pelayo R, Hatfield TJ, Speir VJ, Wu J, Caughey AB (2012) Limitations of the fetal anatomic survey via ultrasound in the obese obstetrical population. J Matern Fetal Neonatal Med 25(10):1945–1949
Cnattingius S, Villamor E (2016) Weight change between successive pregnancies and risks of stillbirth and infant mortality: a nationwide cohort study. Lancet 387(10018):558–565
Dabelea D, Crume T (2011) Maternal environment and the transgenerational cycle of obesity and diabetes. Diabetes 60(7):1849–1855
Dar P, Curnow KJ, Gross SJ, Hall MP, Stosic M, Demko Z, Zimmermann B, Hill M, Sigurjonsson S, Ryan A, Banjevic M, Kolacki PL, Koch SW, Strom CM, Rabinowitz M, Benn P (2014) Clinical experience and follow-up with large scale single-nucleotide polymorphism-based noninvasive prenatal aneuploidy testing. Am J Obstet Gynecol 211(5):527.e1–527.e17
Dashe JS, McIntire DD, Twickler DM (2009) Effect of maternal obesity on the ultrasound detection of anomalous fetuses. Obstet Gynecol 113:1001–1007
Davidoff A, Reuter K, Karellas A et al (1994) Maternal umbilicus: ultrasound window to the gravid uterus. J Clin Ultrasound 22:263–267
Davies GAL, Maxwell C, McLeod L (2018) No. 239-obesity in pregnancy. J Obstet Gynaecol Can 40(8):e630–e639
Denison FC, MacGregor H, Stirrat LI, Stevenson K, Norman JE, Reynolds RM (2017) Does attendance at a specialist antenatal clinic improve clinical outcomes in women with class III obesity compared with standard care? A retrospective case-note analysis. BMJ Open 7(5):e015218
Derraik JG, Ahlsson F, Diderholm B, Lundgren M (2015) Obesity rates in two generations of Swedish women entering pregnancy, and associated obesity risk among adult daughters. Sci Rep 5:16692
Di Cianni G, Miccoli R, Volpe L, Lencioni C, Ghio A, Giovannitti MG, Cuccuru I, Pellegrini G, Chatzianagnostou K, Boldrini A, Del Prato S (2005) Maternal triglyceride levels and newborn weight in pregnant women with normal glucose tolerance. Diabet Med 22(1):21–25
Dodd JM, Whitehead CL (2017) Obesity: maternal obesity and congenital anomalies – risk and diagnosis. Nat Rev Endocrinol 13(9):504–506
Dodd JM, Louise J, Deussen AR, McPhee AJ, Owens JA, Robinson JS (2018) Prenatal diet and child growth at 18 months. Pediatrics 142(3) pii: e20180035. https://doi.org/10.1542/peds.2018-0035
Dolin CD, Kominiarek MA (2018) Pregnancy in women with obesity. Obstet Gynecol Clin N Am 45(2):217–232
Durst JK, Tuuli MG, Stout MJ, Macones GA, Cahill AG (2016) Degree of obesity at delivery and risk of preeclampsia with severe features. Am J Obstet Gynecol 214(5):651.e1–651.e5
Eastwood KA, Daly C, Hunter A, McCance D, Young I, Holmes V (2017) The impact of maternal obesity on completion of fetal anomaly screening. J Perinat Med 45(9):1061–1067
Edlow AG (2017) Maternal obesity and neurodevelopmental and psychiatric disorders in offspring. Prenat Diagn 37(1):95–110
Ehrenberg HM, Dierker L, Milluzzi C et al (2002) Prevalence of maternal obesity in an urban center. Am J Obstet Gynecol 187:1189–1193
Enzensberger C, Pulvermacher C, Degenhardt J, Kawacki A, Germer U, Gembruch U, Krapp M, Weichert J, Axt-Fliedner R (2012) Fetal loss rate and associated risk factors after amniocentesis, chorionic villus sampling and fetal blood sampling. Ultraschall Med 33(7):E75–E79
Eriksson JG, Sandboge S, Salonen M, Kajantie E, Osmond C (2015) Maternal weight in pregnancy and offspring body composition in late adulthood: findings from the Helsinki Birth Cohort Study (HBCS). Ann Med 47:94–99
Eskes TK (2006) Abnormal folate metabolism in mothers with Down syndrome offspring: review of the literature. Eur J Obstet Gynecol Reprod Biol 124(2):130–133
Euliano TY, Nguyen MT, Marossero D et al (2007) Monitoring contractions in obese parturients: electrohysterography compared with traditional monitoring. Obstet Gynecol 109:1136–1140
Faschingbauer F, Raabe E, Heimrich J, Faschingbauer C, Schmid M, Mayr A, Schild RL, Beckmann MW, Kehl S (2016) Accuracy of sonographic fetal weight estimation: influence of the scan-to-delivery interval in combination with the applied weight estimation formula. Arch Gynecol Obstet 294(3):487–493
Fedorcsák P, Storeng R, Dale PO et al (2000) Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 79:43–48
Flenady V, Koopmans L, Middleton P, Frøen JF, Smith GC, Gibbons K, Coory M, Gordon A, Ellwood D, McIntyre HD, Fretts R, Ezzati M (2011) Major risk factors for stillbirth in high-income countries: a systematic review and meta-analysis. Lancet 377(9774):1331–1340
Forno E, Young OM, Kumar R, Simhan H, Celedón JC (2014) Maternal obesity in pregnancy, gestational weight gain, and risk of childhood asthma. Pediatrics 134(2):e535–e546
Forsén T, Eriksson JG, Tuomilehto J, Teramo K, Osmond C, Barker DJ (1997) Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ 315:837–840
Forthun I, Wilcox AJ, Strandberg-Larsen K, Moster D, Nohr EA, Lie RT, Surén P, Tollånes MC (2016) Maternal prepregnancy BMI and risk of cerebral palsy in offspring. Pediatrics 138(4). pii: e20160874
Fuchs F, Houllier M, Voulgaropoulos A, Levaillant JM, Colmant C, Bouyer J, Senat MV (2013) Factors affecting feasibility and quality of second-trimester ultrasound scans in obese pregnant women. Ultrasound Obstet Gynecol 41(1):40–46
Gaillard R, Steegers EA, Franco OH, Hofman A, Jaddoe VW (2015) Maternal weight gain in different periods of pregnancy and 37 childhood cardio-metabolic outcomes. The Generation R Study. Int J Obes 39:677–685
Gandhi M, Fox NS, Russo-Stieglitz K et al (2009) Effect of increased body mass index on first-trimester ultrasound examination for aneuploidy risk assessment. Obstet Gynecol 114:856–859
Gardosi J, Madurasinghe V, Williams M, Malik A, Francis A (2013) Maternal and fetal risk factors for stillbirth: population based study. BMJ f108:346
Gaudet L, Wen SW, Walker M (2014) The combined effect of maternal obesity and fetal macrosomia on pregnancy outcomes. J Obstet Gynaecol Can 36(9):776–784
Ghidini A (2014) Maternal obesity and Down syndrome in the offspring: is there a link? Prenat Diagn 34(4):307–309
Gibson KS, Stetzer B, Catalano PM, Myers SA (2016) Comparison of 2- and 3-dimensional sonography for estimation of birth weight and neonatal adiposity in the setting of suspected fetal macrosomia. J Ultrasound Med 35(6):1123–1129
Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH (2017) Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 50(3):302–314
Godfrey KM, Costello PM, Lillycrop KA (2015) The developmental environment, epigenetic biomarkers and long-term health. J Dev Orig Health Dis 6(5):399–406
Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, Broekman BF (2017) Influence of maternal obesity on the long-term health of offspring. Lancet Diabetes Endocrinol 5(1):53–64
Goffman D, Madden RC, Harrison EA et al (2007) Predictors of maternal mortality and near-miss maternal morbidity. J Perinatol 27:597–601
Goldman KN, Hodes-Wertz B, McCulloh DH, Flom JD, Grifo JA (2015) Association of body mass index with embryonic aneuploidy. Fertil Steril 103(3):744–748
Goodall PT, Ahn JT, Chapa JB et al (2005) Obesity as a risk factor for failed trial of labor in patients with previous cesarean delivery. Am J Obstet Gynecol 192:1423–1426
Gregg AR, Skotko BG, Benkendorf JL, Monaghan KG, Bajaj K, Best RG, Klugman S, Watson MS (2016) Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics. Genet Med 18(10):1056–1065
Gupta S, Timor-Tritsch IE, Oh C, Chervenak J, Monteagudo A (2014) Early second-trimester sonography to improve the fetal anatomic survey in obese patients. J Ultrasound Med 33(9):1579–1583
Gurram P, Benn P, Grady J, Prabulos AM, Campbell W (2014) First trimester aneuploidy screening markers in women with pre-gestational diabetes mellitus. J Clin Med 3(2):480–490
Haghiac M, Vora NL, Basu S, Johnson KL, Presley L, Bianchi DW, Hauguel-de Mouzon S (2012) Increased death of adipose cells, a path to release cell-free DNA into systemic circulation of obese women. Obesity (Silver Spring) 20(11):2213–2219
Hall LF, Neubert AG (2005) Obesity and pregnancy. Obstet Gynecol Surv 60:253–260
Harper LM, Cahill AG, Smith K, Macones GA, Odibo AO (2012) Effect of maternal obesity on the risk of fetal loss after amniocentesis and chorionic villus sampling. Obstet Gynecol 119(4):745–751
Harper LM, Jauk VC, Owen J, Biggio JR (2014) The utility of ultrasound surveillance of fluid and growth in obese women. Am J Obstet Gynecol 211(5):524.e1–524.e8
Hellmuth C, Uhl O, Standl M, Demmelmair H, Heinrich J, Koletzko B, Thiering E (2017) Cord blood metabolome is highly associated with birth weight, but less predictive for later weight development. Obes Facts 10(2):85–100
Hendler I, Blackwell SC, Treadwell MC et al (2004a) Does advanced ultrasound equipment improve the adequacy of ultrasound visualization of fetal cardiac structures in the obese gravid woman? Am J Obstet Gynecol 190:1616–1619
Hendler I, Blackwell SC, Bujold E et al (2004b) The impact of maternal obesity on midtrimester sonographic visualization of fetal cardiac and craniospinal structures. Int J Obes Relat Metab Disord 28:1607–1611
Hendler I, Blackwell SC, Bujold E et al (2005) Suboptimal second-trimester ultrasonographic visualization of the fetal heart in obese women: should we repeat the examination? J Ultrasound Med 24:1205–1209
Heslehurst N, Simpson H, Ells LJ et al (2008) The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obes Rev 9:635–683
Hijazi ZR, East CE (2009) Factors affecting maternal perception of fetal movement. Obstet Gynecol Surv 64:489–497
Hildebrand E, Gottvall T, Blomberg M (2013) Maternal obesity and detection rate of fetal structural anomalies. Fetal Diagn Ther 33(4):246–251
Hildebrand E, Källén B, Josefsson A, Gottvall T, Blomberg M (2014) Maternal obesity and risk of Down syndrome in the offspring. Prenat Diagn 34(4):310–315
Hilson JA, Rasmussen KM, Kjolhede CL (2006) Excessive weight gain during pregnancy is associated with earlier termination of breast-feeding among white women. J Nutr 136:140–146
Huang T, Meschino WS, Okun N, Dennis A, Hoffman B, Lepage N, Rashid S, Aul R, Farrell SA (2013) The impact of maternal weight discrepancies on prenatal screening results for Down syndrome. Prenat Diagn 33(5):471–476
Hunsley C, Farrell T (2014) The influence of maternal body mass index on fetal anomaly screening. Eur J Obstet Gynecol Reprod Biol 182:181–184
Isganaitis E, Rifas-Shiman SL, Oken E, Dreyfuss JM, Gall W, Gillman MW, Patti ME (2015) Associations of cord blood metabolites with early childhood obesity risk. Int J Obes 39(7):1041–1048
Jackson RA, Gibson KA, Wu YW et al (2004) Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 103:551–563
James AH, Jamison MG, Brancazio LR et al (2006) Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol 194:1311–1315
Johansson S, Villamor E, Altman M, Bonamy AK, Granath F, Cnattingius S (2014) Maternal overweight and obesity in early pregnancy and risk of infant mortality: a population based cohort study in Sweden. BMJ g6572:349
Jurewicz J, Radwan M, Sobala W, Radwan P, Jakubowski L, Hawuła W, Ulańska A, Hanke W (2014) Lifestyle factors and sperm aneuploidy. Reprod Biol 14(3):190–199
Kabiru W, Raynor BD (2004) Obstetric outcomes associated with increase in BMI category during pregnancy. Am J Obstet Gynecol 191:928–932
Kagan KO, Sroka F, Sonek J, Abele H, Lüthgens K, Schmid M, Wagner P, Brucker S, Wallwiener D, Hoopmann M (2018) First-trimester risk assessment based on ultrasound and cell-free DNA vs combined screening: a randomized controlled trial. Ultrasound Obstet Gynecol 51(4):437–444
Karim JN, Roberts NW, Salomon LJ, Papageorghiou AT (2017) Systematic review of first-trimester ultrasound screening for detection of fetal structural anomalies and factors that affect screening performance. Ultrasound Obstet Gynecol 50(4):429–441
Kesrouani A, Atallah C, AbouJaoude R, Assaf N, Khaled H, Attieh E (2017) Accuracy of clinical fetal weight estimation by Midwives. BMC Pregnancy Childbirth. 17(1):59
Khoury FR, Ehrenberg HM, Mercer BM (2009) The impact of maternal obesity on satisfactory detailed anatomic ultrasound image acquisition. J Matern Fetal Neonatal Med 22:337–341
Kleinwechter H, Schäfer-Graf U, Bührer C, Hoesli I, Kainer F, Kautzky-Willer A, Pawlowski B, Schunck K, Somville T, Sorger M (2017) Diabetes und Schwangerschaft. DDG Praxisempfehlung. Diabetologie 12(Suppl 2):233–241
Kolås T, Øian P, Skjeldestad FE (2010) Risks for peroperative excessive blood loss in cesarean delivery. Acta Obstet Gynecol Scand 89:658–663
Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C (2018) The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics 142(3). pii: e20180776
Kozlowski P, Burkhardt T, Gembruch U, Gonser M, Kähler C, Kagan KO, von Kaisenberg C, Klaritsch P, Merz E, Steiner H, Tercanli S, Vetter K, Schramm T (2018) DEGUM, ÖGUM, SGUM and FMF Germany Recommendations for the Implementation of First-Trimester Screening, Detailed Ultrasound, Cell-Free DNA Screening and Diagnostic Procedures. Ultraschall Med. 2019 Apr;40(2):176–193
Kritzer S, Magner K, Warshak CR (2014) Increasing maternal body mass index and the accuracy of sonographic estimation of fetal weight near delivery. J Ultrasound Med 33(12):2173–2179
Kumari AS (2001) Pregnancy outcome in women with morbid obesity. Int J Gynaecol Obstet 73:101–107
Kushner RF, Kahan S (2018) Introduction: the state of obesity in 2017. Med Clin North Am 102(1):1–11
Landres IV, Milki AA, Lathi RB (2010) Karyotype of miscarriages in relation to maternal weight. Hum Reprod 25:1123–1126
Lanowski JS, Lanowski G, Schippert C, Drinkut K, Hillemanns P, Staboulidou I (2017) Ultrasound versus clinical examination to estimate fetal weight at term. Geburtshilfe Frauenheilkd 77(3):276–283
Lantz ME, Chisholm CA (2004) The preferred timing of second-trimester obstetric sonography based on maternal body mass index. J Ultrasound Med 23(8):1019–1022
Lashen H, Fear K, Sturdee DW (2004) Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod 19(7):1644–1646
Leddy MA, Power ML, Schulkin J (2008) The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol 1:170–178
Lindam A, Johansson S, Stephansson O, Wikström AK, Cnattingius S (2016) High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality-a population-based sibling study in Sweden. Am J Epidemiol 184(2):98–105
Lisonkova S, Muraca GM, Potts J, Liauw J, Chan WS, Skoll A, Lim KI (2017) Association between prepregnancy body mass index and severe maternal morbidity. JAMA 318(18):1777–1786
Livergood MC, LeChien KA, Trudell AS (2017) Obesity and cell-free DNA „no calls“: is there an optimal gestational age at time of sampling? Am J Obstet Gynecol 216(4):413.e1–413.e9
Luzzo KM, Wang Q, Purcell SH, Chi M, Jimenez PT, Grindler N, Schedl T, Moley KH (2012) High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. PLoS One 7(11):e49217
Mack LM, Kim SY, Lee S, Sangi-Haghpeykar H, Lee W (2017) Automated fractional limb volume measurements improve the precision of birth weight predictions in late third-trimester fetuses. J Ultrasound Med 36(8):1649–1655
Magnus MC, Olsen SF, Granstrom C, Lund-Blix NA, Svensson J, Johannesen J, Fraser A, Skrivarhaug T, Joner G, Njølstad PR, Størdal K, Stene LC (2018) Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes. Int J Epidemiol 47(2):417–426
Marciniak A, Patro-Małysza J, Kimber-Trojnar Ż, Marciniak B, Oleszczuk J, Leszczyńska-Gorzelak B (2017) Fetal programming of the metabolic syndrome. Taiwan J Obstet Gynecol 56(2):133–138
Maruotti GM, Saccone G, Martinelli P (2017) Third trimester ultrasound soft-tissue measurements accurately predicts macrosomia. J Matern Fetal Neonatal Med 30(8):972–976
Maxwell C, Glanc P (2011) Imaging and obesity: a perspective during pregnancy. AJR Am J Roentgenol 196(2):311–319
McCoy MC, Watson WJ, Chescheir NC et al (1996) Transumbilical use of the endovaginal probe. Am J Perinatol 13:395–397
McCurdy CE, Bishop JM, Williams SM, Grayson BE, Smith MS, Friedman JE, Grove KL (2009) Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 119(2):323–335
McGuire W, Dyson L, Renfrew M (2010) Maternal obesity: consequences for children, challenges for clinicians and carers. Semin Fetal Neonatal Med 15(2):108–112
Mehta SK, Richards N, Lorber R, Rosenthal GL (2009) Abdominal obesity, waist circumference, body mass index, and echocardiographic measures in children and adolescents. Congenit Heart Dis 4(5):338–347
Metwally M, Ong KJ, Ledger WL et al (2008) Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 90:714–726
Metwally M, Saravelos SH, Ledger WL et al (2010) Body mass index and risk of miscarriage in women with recurrent miscarriage. Fertil Steril 94:290–295
Metzger B, Lowe L, Dyer A, Coustan D, Hadden D, Hod M, Oats J, Persson B, Trimble E (2010) The Hyperglycemia Adverse Pregnancy Outcome (HAPO) Study: associations of higher levels of maternal glucose and BMI with macrosomia: an example of diabesity. 154 OR
Molyneaux E, Poston L, Ashurst-Williams S, Howard LM (2014) Obesity and mental disorders during pregnancy and postpartum: a systematic review and meta-analysis. Obstet Gynecol 123(4):857–867
Mone F, Mulcahy C, McParland P, McAuliffe FM (2017) Should we recommend universal aspirin for all pregnant women? Am J Obstet Gynecol 216(2):141.e1–141.e5
Moore TR (2004) Adolescent and adult obesity in women: a tidal wave just beginning. Clin Obstet Gynecol 47(4):884–889
Moore GS, Post AL, West NA, Hart JE, Lynch AM (2015) Fetal weight estimation in diabetic pregnancies using the gestation-adjusted projection method: comparison of two timing strategies for third-trimester sonography. J Ultrasound Med 34(6):971–975
NCD Risk Factor Collaboration (NCD-RisC) (2016) Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet 387(10026):1377–1396
NCD Risk Factor Collaboration (NCD-RisC) (2017) Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. Lancet 390(10113):2627–2642
Neveux LM, Palomaki GE, Larrivee DA, Knight GJ, Haddow JE (1996) Refinements in managing maternal weight adjustment for interpreting prenatal screening results. Prenat Diagn 16(12):1115–1119
Nohr EA, Vaeth M, Baker JL, Sørensen TIA, Olsen J, Rasmussen KM (2008) Combined associations of prepregnancy body mass index and gestational weight gain with the outcome of pregnancy. Am J Clin Nutr 87(6):1750–1759
Norton ME, Kuppermann M (2016) Women should decide which conditions matter. Am J Obstet Gynecol 215(5):583–587.e1
Norton ME, Jacobsson B, Swamy GK, Laurent LC, Ranzini AC, Brar H, Tomlinson MW, Pereira L, Spitz JL, Hollemon D, Cuckle H, Musci TJ, Wapner RJ (2015) Cell-free DNA analysis for noninvasive examination of trisomy. N Engl J Med 372(17):1589–1597
O’Brien K, Shainker SA, Modest AM, Spiel MH, Resetkova N, Shah N, Hacker MR (2017) Cost analysis of following up incomplete low-risk fetal anatomy ultrasounds. Birth 44(1):35–40
Odibo AO, Cahill A, Macones G et al (2010) Maternal obesity and fetal loss rates from prenatal invasive procedures (abstr). Ultrasound Obstet Gynecol 36(Suppl 1):S37
OECD (2017) https://www.oecd.org/health/obesity-update.htm
Padula F, Gulino FA, Capriglione S, Giorlandino M, Cignini P, Mastrandrea ML, D'Emidio L, Giorlandino C (2015) What is the rate of incomplete fetal anatomic surveys during a second-trimester scan? Retrospective observational study of 4000 nonobese pregnant women. J Ultrasound Med 34(12):2187–2191
Paladini D (2009) Sonography in obese and overweight pregnant women: clinical, medicolegal and technical issues. Ultrasound Obstet Gynecol 33:720–729
Palomaki GE, Lambert-Messerlian GM, Haddow JE (2016) Where have all the trisomies gone? Am J Obstet Gynecol 215(5):583–587.e1
Pasko DN, Wood SL, Jenkins SM, Owen J, Harper LM (2016) Completion and sensitivity of the second-trimester fetal anatomic survey in obese gravidas. J Ultrasound Med 35(11):2449–2457
Pergament E, Cuckle H, Zimmermann B, Banjevic M, Sigurjonsson S, Ryan A, Hall MP, Dodd M, Lacroute P, Stosic M, Chopra N, Hunkapiller N, Prosen DE, McAdoo S, Demko Z, Siddiqui A, Hill M, Rabinowitz M (2014) Single-nucleotide polymorphism-based noninvasive prenatal screening in a high-risk and low-risk cohort. Obstet Gynecol 124(2 Pt 1):210–218
Persson M, Cnattingius S, Villamor E, Söderling J, Pasternak B, Stephansson O, Neovius M (2017) Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons. BMJ 357:j2563
Petersen AK, Cheung SW, Smith JL, Bi W, Ward PA, Peacock S, Braxton A, Van Den Veyver IB, Breman AM (2017) Positive predictive value estimates for cell-free noninvasive prenatal screening from data of a large referral genetic diagnostic laboratory. Am J Obstet Gynecol 217(6):691.e1–691.e6
Phatak M, Ramsay J (2010) Impact of maternal obesity on procedure of mid-trimester anomaly scan. J Obstet Gynaecol 30(5):447–450
Porter B, Neely C, Szychowski J, Owen J (2015) Ultrasonographic fetal weight estimation: should macrosomia-specific formulas be utilized? Am J Perinatol 32(10):968–972
Poston L, Bell R, Croker H, Flynn AC, Godfrey KM, Goff L, Hayes L, Khazaezadeh N, Nelson SM, Oteng-Ntim E, Pasupathy D, Patel N, Robson SC, Sandall J, Sanders TA, Sattar N, Seed PT, Wardle J, Whitworth MK, Briley AL, UPBEAT Trial Consortium (2015) Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol 3(10):767–777
Queisser-Luft A, Kieninger-Baum D, Menger H et al (1998) Does maternal obesity increase the risk of fetal abnormalities? Analysis of 20,248 newborn infants of the Mainz Birth Register for detecting congenital abnormalities. Ultraschall Med 19:40–44
Rasmussen SA, Chu SY, Kim SY et al (2008) Maternal obesity and risk of neural tube defects: a metaanalysis. Am J Obstet Gynecol 198:611–619
Rasmussen S, Irgens LM, Espinoza J (2014) Maternal obesity and excess of fetal growth in pre-eclampsia. BJOG 121(11):1351–1357
Ray JG, Wyatt PR, Vermeulen MJ, Meier C, Cole DE (2005) Greater maternal weight and the ongoing risk of neural tube defects after folic acid flour fortification. Obstet Gynecol 105(2):261–265
Ray A, Hildreth A, Esen UI (2008) Morbid obesity and intra-partum care. J Obstet Gynaecol 28:301–304
Rayanagoudar G, Hashi AA, Zamora J, Khan KS, Hitman GA, Thangaratinam S (2016) Quantification of the type 2 diabetes risk in women with gestational diabetes: a systematic review and meta-analysis of 95,750 women. Diabetologia 59(7):1403–1411
RCOG (2015) https://www.rcog.org.uk/globalassets/documents/guidelines/gtg-37a.pdf
Reichler A, Sherer DM, Divon MY (1997) Transvaginal sonographic imaging of early second-trimester fetal anatomy assisted by uterine fundal pressure. Obstet Gynecol 89(6):949–952
Revello R, Sarno L, Ispas A, Akolekar R, Nicolaides KH (2016) Screening for trisomies by cell-free DNA testing of maternal blood: consequences of a failed result. Ultrasound Obstet Gynecol 47(6):698–704
Reynolds RM, Allan KM, Raja EA et al (2013) Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1323275 person years. BMJ f4539:347
Robillard PY, Dekker G, Chaouat G, Scioscia M, Iacobelli S, Hulsey TC (2017) Historical evolution of ideas on eclampsia/preeclampsia: a proposed optimistic view of preeclampsia. J Reprod Immunol 123:72–77
Robinson HE, O'Connell CM, Joseph KS et al (2005) Maternal outcomes in pregnancies complicated by obesity. Obstet Gynecol 106:1357–1364
Roelants JA, Vermeulen MJ, Koning IV, Groenenberg IAL, Willemsen SP, Hokken-Koelega ACS, Joosten KFM, Reiss IKM, Steegers-Theunissen RPM (2017) Foetal fractional thigh volume: an early 3D ultrasound marker of neonatal adiposity. Pediatr Obes 12(Suppl 1):65–71
Rose NC (2016) Genetic screening and the obese gravida. Clin Obstet Gynecol 59(1):140–147
Rosenberg JC, Guzman ER, Vintzileos AM et al (1995) Transumbilical placement of the vaginal probe in obese pregnant women. Obstet Gynecol 85:132–134
Ryan A, Hunkapiller N, Banjevic M, Vankayalapati N, Fong N, Jinnett KN, Demko Z, Zimmermann B, Sigurjonsson S, Gross SJ, Hill M (2016) Validation of an enhanced version of a single-nucleotide polymorphism-based noninvasive prenatal test for detection of fetal aneuploidies. Fetal Diagn Ther 40(3):219–223
Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16(1):1–8
Sakowicz A, Grobman WA, Tankou J, Miller E (2018) The diagnostic utility of growth ultrasound for the indication of maternal overweight or obesity. Am J Obstet Gynecol 218(Suppl. 1):S273
Salihu HM, Alio AP, Belogolovkin V, Aliyu MH, Wilson RE, Reddy UM, Bruder K, Whiteman VE (2010) Prepregnancy obesity and risk of stillbirth in viable twin gestations. Obesity (Silver Spring) 18(9):1795–1800
Schienkiewitz A, Mensink G, Kuhnert R, Lange C (2017) Übergewicht und Adipositas bei Erwachsenen in Deutschland. J Health Monit 2:21–28
Schrauwers C, Dekker G (2009) Maternal and perinatal outcome in obese pregnant patients. J Matern Fetal Neonatal Med 22:218–226
Sebire NJ, Jolly M, Harris JP et al (2001) Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord 25:1175–1182
Shaffer BL, Norton ME (2018) Cell-free DNA screening for aneuploidy and microdeletion syndromes. Obstet Gynecol Clin N Am 45(1):13–26
Siega-Riz AM, Herring AH, Olshan AF et al (2009) The joint effects of maternal prepregnancy body mass index and age on the risk of gastroschisis. Paediatr Perinat Epidemiol 23:51–57
Silvestri MT, Pettker CM, Raney JH, Xu X, Ross JS (2016) Frequency and importance of incomplete screening fetal anatomic sonography in pregnancy. J Ultrasound Med 35(12):2665–2673
Simic M, Wåhlin IA, Marsál K, Källén K (2010) Maternal obesity is a potential source of error in mid-trimester ultrasound estimation of gestational age. Ultrasound Obstet Gynecol 35(1):48–53
Sohan K, Woodward B, Ramsewak SS (2004) Successful use of transrectal ultrasound for embryo transfer in obese women. J Obstet Gynaecol 24(7):839–840
Spencer K, Bindra R, Nicolaides KH (2003) Maternal weight correction of maternal serum PAPP-A and free beta-hCG MoM when screening for trisomy 21 in the first trimester of pregnancy. Prenat Diagn 23(10):851–855
Spencer K, Cowans NJ, Spencer CE, Achillea N (2010) A re-evaluation of the influence of maternal insulin-dependent diabetes on fetal nuchal translucency thickness and first-trimester maternal serum biochemical markers of aneuploidy. Prenat Diagn 30(10):937–940
Spradley FT (2017) Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia. Am J Phys Regul Integr Comp Phys 312(1):R5–R12
Spradley FT, Palei AC, Granger JP (2015) Increased risk for the development of preeclampsia in obese pregnancies: weighing in on the mechanisms. Am J Phys Regul Integr Comp Phys 309(11):R1326–R1343
Stothard KJ, Tennant PW, Bell R et al (2009) Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301:636–650
Stott-Miller M, Heike CL, Kratz M, Starr JR (2010) Increased risk of orofacial clefts associated with maternal obesity: case-control study and Monte Carlo-based bias analysis. Paediatr Perinat Epidemiol 24:502–512
Suzumori N, Ebara T, Yamada T, Samura O, Yotsumoto J, Nishiyama M, Miura K, Sawai H, Murotsuki J, Kitagawa M, Kamei Y, Masuzaki H, Hirahara F, Saldivar JS, Dharajiya N, Sago H, Sekizawa A, Japan NIPT Consortium (2016) Fetal cell-free DNA fraction in maternal plasma is affected by fetal trisomy. J Hum Genet 61(7):647–652
Syngelaki A, Bredaki FE, Vaikousi E, Maiz N, Nicolaides KH (2011) Body mass index at 11-13 weeks’ gestation and pregnancy complications. Fetal Diagn Ther 30(4):250–265
Tang X, Nick TG, Cleves MA, Erickson SW, Li M, Li J, MacLeod SL, Hobbs CA (2014) Maternal obesity and tobacco use modify the impact of genetic variants on the occurrence of conotruncal heart defects. PLoS One 9(9):e108903
The Lancet Diabetes Endocrinology (2017) Should we officially recognise obesity as a disease? Lancet Diabetes Endocrinol 5(7):483
Thornburg L, Young C, Pressman E (2006) Accuracy of sonographic birth weight prediction in obese parturients using the gestation-adjusted projection method. Am J Obstet Gynecol 195:S76
Thornburg LL, Miles K, Ho M et al (2009a) Fetal anatomic evaluation in the overweight and obese gravida. Ultrasound Obstet Gynecol 33:670–675
Thornburg LL, Mulconry M, Post A et al (2009b) Fetal nuchal translucency thickness evaluation in the overweight and obese gravida. Ultrasound Obstet Gynecol 33:665–669
Tuffnell DJ, Cartmill RS, Lilford RJ (1991) Fetal movements; factors affecting their perception. Eur J Obstet Gynecol Reprod Biol 39:165–167
Tuuli MG, Kapalka K, Macones GA, Cahill AG (2016) Three-versus two-dimensional sonographic biometry for predicting birth weight and macrosomia in diabetic pregnancies. J Ultrasound Med 35(9):1925–1930
Uhden M, Knippel AJ, Stressig R, Hammer R, Siegmann H, Froehlich S, Kozlowski P (2011) Impact of maternal obesity and maternal overweight on the detection rate of fetal heart defects and the image quality of prenatal echocardiography. Ultraschall Med 32(Suppl 2):E108–E114
Upadhyay J, Farr O, Perakakis N, Ghaly W, Mantzoros C (2018) Obesity as a Disease. Med Clin North Am 102(1):13–33
Usha Kiran TS, Hemmadi S, Bethel J et al (2005) Outcome of pregnancy in a woman with an increased body mass index. Br J Obstet Gynaecol 112:768–772
Valent AM, Newman T, Kritzer S, Magner K, Warshak CR (2017) Accuracy of sonographically estimated fetal weight near delivery in pregnancies complicated with diabetes mellitus. J Ultrasound Med 36(3):593–599
Vayá A, Rivera L, Hernández-Mijares A, de la Fuente M, Solá E, Romagnoli M, Alis R, Laiz B (2012) Homocysteine levels in morbidly obese patients: its association with waist circumference and insulin resistance. Clin Hemorheol Microcirc 52(1):49–56
Vieira MC, Begum S, Seed PT, Badran D, Briley AL, Gill C, Godfrey KM, Lawlor DA, Nelson SM, Patel N, Sattar N, White SL, Poston L, Pasupathy D, UPBEAT Consortium (2018) Gestational diabetes modifies the association between PlGF in early pregnancy and preeclampsia in women with obesity. Pregnancy Hypertens 13:267–272
Vitner D, Harris K, Maxwell C, Farine D (2018) Obesity in pregnancy: a comparison of four national guidelines. J Matern Fetal Neonatal Med 26:1–11
Waller DK, Shaw GM, Rasmussen SA et al (2007) Prepregnancy obesity as a risk factor for structural birth defects. Arch Pediatr Adolesc Med 161:745–750
Waller SA, O'Connell K, Carter A, Gravett MG, Dighe M, Richardson ML, Dubinsky TJ (2013) Incidence of fetal anomalies after incomplete anatomic surveys between 16 and 22 weeks. Ultrasound Q 29(4):307–312
Wang E, Batey A, Struble C, Musci T, Song K, Oliphant A (2013) Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma. Prenat Diagn 33(7):662–666
Wang F, Wu Y, Quon MJ, Li X, Yang P (2015) ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab 309(5):E487–E499
Watkins ML, Rasmussen SA, Honein MA et al (2003) Maternal obesity and risk for birth defects. Pediatrics 111:1152–1158
Wei S, Schmidt MD, Dwyer T et al (2009) Obesity and menstrual irregularity: associations with SHBG, testosterone, and insulin. Obesity (Silver Spring) 17:1070–1076
Weichert J, Hartge DR (2011) Obstetrical sonography in obese women: a review. J Clin Ultrasound 39(4):209–216
Wolfe HM, Sokol RJ, Martier SM et al (1990) Maternal obesity: a potential source of error in sonographic prenatal diagnosis. Obstet Gynecol 76:339–342
Wong SF, Chan FY, Cincotta RB, Lee-Tannock A, Ward C (2003) Factors influencing the prenatal detection of structural congenital heart diseases. Ultrasound Obstet Gynecol 21(1):19–25
Wood SL, Owen J, Jenkins SM, Harper LM (2018) The Utility of Repeat Midtrimester Anatomy Ultrasound for Anomaly Detection. Am J Perinatol. 2018 Dec;35(14):1346–1351
Woolner AM, Bhattacharya S (2015) Obesity and stillbirth. Best Pract Res Clin Obstet Gynaecol 29(3):415–426
Wright C, Smith B, Wright S, Weiner M, Wright K, Rubin D (2014) Who develops carpal tunnel syndrome during pregnancy: an analysis of obesity, gestational weight gain, and parity. Obstet Med 7(2):90–94
Yao R, Ananth CV, Park BY, Pereira L, Plante LA, Perinatal Research Consortium (2014) Obesity and the risk of stillbirth: a population-based cohort study. Am J Obstet Gynecol 210(5):457.e1–457.e9
Yao R, Park BY, Foster SE, Caughey AB (2017) The association between gestational weight gain and risk of stillbirth: a population-based cohort study. Ann Epidemiol 27(10):638–644.e1
Yao R, Schuh BL, Caughey AB (2019) The risk of perinatal mortality with each week of expectant management in obese pregnancies. J Matern Fetal Neonatal Med 32(3):434–441
Yared E, Dinsmoor MJ, Endres LK, Van den Berg MJ, Maier Hoell CJ, Lapin B, Plunkett BA (2016) Obesity increases the risk of failure of noninvasive prenatal screening regardless of gestational age. Am J Obstet Gynecol 215(3):370.e1–370.e6
Yeung EH, Sundaram R, Ghassabian A, Xie Y, Buck Louis G (2017) Parental obesity and early childhood development. Pediatrics 139(2). pii: e20161459. https://doi.org/10.1542/peds.2016-1459. Epub 2017 Jan 2
Zhang J, Peng L, Chang Q, Xu R, Zhong N, Huang Q, Zhong M, Yu Y (2018) Maternal obesity and risk of cerebral palsy in children: a systematic review and meta-analysis. Dev Med Child Neurol. 2019 Jan;61(1):31–38
Zhou Y, Zhu Z, Gao Y, Yuan Y, Guo Y, Zhou L, Liao K, Wang J, Du B, Hou Y, Chen Z, Chen F, Zhang H, Yu C, Zhao L, Lau TK, Jiang F, Wang W (2015) Effects of maternal and fetal characteristics on cell-free fetal DNA fraction in maternal plasma. Reprod Sci 22(11):1429–1435
Zhu Y, Chen Y, Feng Y, Yu D, Mo X (2018) Association between maternal body mass index and congenital heart defects in infants: a meta-analysis. Congenit Heart Dis 13(2):271–281
Zozzaro-Smith P, Gray LM, Bacak SJ, Thornburg LL (2014) Limitations of aneuploidy and anomaly detection in the obese patient. J Clin Med 3(3):795–808
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Weichert, J. (2022). Adipositas und Schwangerschaftsrisiken. In: Strauss, A., Strauss, C. (eds) Praxisbuch Adipositas in der Geburtshilfe . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61906-3_6
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