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Palliative Care in Older Adults with Cancer and Frailty

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Frailty in Older Adults with Cancer

Abstract

Palliative care is an approach to care addressing quality of life, pain and distress symptoms, and psychological and spiritual well-being in patients with serious illness. Access to palliative care is critical, and the early integration of palliative care has a substantial benefit for patients with cancer. In older patients with cancer who are frail, palliative care may be the primary initial treatment approach, helping to mitigate or even avoid the significant adverse effects from cancer therapy to which frail older adults are more susceptible. Frail older adults have unique palliative needs due to higher rates of comorbid conditions, functional impairments, and high rates of complications and symptoms at the end-of-life. This chapter will discuss the availability of palliative care, the ease of access in older adults, the benefits of early integration of palliative care in oncology treatments, pharmacological considerations in older adults, and a special focus on the specifics of care in older cancer patients with frailty.

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References

  1. World Health Organization. WHO Definition for Palliative Care. Available at: https://www.who.int/cancer/palliative/definition/en/. Accessed October 23, 2020.

  2. Hui D, De La Cruz M, Mori M, Parsons HA, Kwon JH, Torres-Vigil I, et al. Concepts and definitions for “supportive care,” “best supportive care,” “palliative care,” and “hospice care” in the published literature, dictionaries, and textbooks. Support Care Cancer. 2013 Mar;21(3):659–85.

    Article  PubMed  Google Scholar 

  3. Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017 Jan;35(1):96–112.

    Article  PubMed  Google Scholar 

  4. National Hospice and Palliative Care : Hopsice Care Overview for Professionals. 2020.; Available at https://www.nhpco.org/hospice-care-overview/hospice-faqs/. Accessed 25 October 2020.

  5. Saunders DCM, Clark D. Cicely Saunders: selected writings 1958-2004. Oxford: Oxford University Press; 2006.

    Book  Google Scholar 

  6. Irish Hospice Foundation. What is Hospice Care. 2020; Available at: https://hospicefoundation.ie/aboutus/hospice-palliative-and-end-of-life-care/what-is-hospice-care/. Accessed 25 October 2020.

  7. Walker DK, Edwards RL, Bagcivan G, Bakitas MA. Cancer and palliative care in the United States, Turkey, and Malawi: developing global collaborations. Asia Pac J Oncol Nurs. 2017 Jul–Sep;4(3):209–19.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kanasi E, Ayilavarapu S, Jones J. The aging population: demographics and the biology of aging. Periodontol 2000. 2016;72(1):13–8.

    Article  PubMed  Google Scholar 

  9. Trends G. Public health and aging: trends in aging—United States and worldwide. Public Health. 2003;347:921–5.

    Google Scholar 

  10. Blackwell DL, Lucas JW, Clarke TC. Summary health statistics for U.S. adults: national health interview survey, 2012. Vital Health Stat. 2014 Feb;260:1–161.

    Google Scholar 

  11. López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194–217.

    Article  PubMed  PubMed Central  Google Scholar 

  12. American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Guiding principles for the care of older adults with multimorbidity: an approach for clinicians. J Am Geriatr Soc. 2012;60(10):E1–E25.

    Article  PubMed Central  Google Scholar 

  13. Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005 Aug;173(5):489–95.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Mohile SG, Epstein RM, Hurria A, Heckler CE, Canin B, Culakova E, et al. Communication with older patients with cancer using geriatric assessment: a cluster-randomized clinical trial from the National Cancer Institute Community Oncology Research Program. JAMA Oncol. 2020 Feb 1;6(2):196–204.

    Article  PubMed  Google Scholar 

  15. National Comprehensive Cancer Network. National Comprehensive Cancer Network Guidelines in Oncology - Older Adult Oncology. 2020. Available at https://www.nccn.org/professionals/physician_gls/pdf/senior.pdf. Accessed 3 Nov 2020.

  16. Morrison RS, Augustin R, Souvanna P, Meier DE. America’s care of serious illness: a state-by-state report card on access to palliative care in our nation’s hospitals. J Palliat Med. 2011;14(10):1094–6.

    Article  PubMed  PubMed Central  Google Scholar 

  17. WHO. Global Atlas of Palliative care at the end of life. Geneva: WHO; 2014.

    Google Scholar 

  18. Chapman M, Le B, Gorelik A, Schwarz J. Prognostic factors in the elderly: a profile and outcomes study of a community palliative care service. Intern Med J. 2012;42(9):1046–9.

    Article  CAS  PubMed  Google Scholar 

  19. Young J, Badgery-Parker T, Dobbins T, Jorgensen M, Gibbs P, Faragher I, et al. Comparison of ECOG/WHO performance status and ASA score as a measure of functional status. J Pain Symptom Manag. 2015;49(2):258–64.

    Article  Google Scholar 

  20. Loh KP, Soto-Perez-de-Celis E, Hsu T, de Glas NA, Battisti NML, Baldini C, et al. What every oncologist should know about geriatric assessment for older patients with cancer: young international society of geriatric oncology position paper. J Oncol Pract. 2018;14(2):85–94.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Abernethy AP, Wheeler JL, Currow DC. Utility and use of palliative care screening tools in routine oncology practice. Cancer J. 2010;16(5):444–60.

    Article  PubMed  Google Scholar 

  22. Rodriguez KL, Barnato AE, Arnold RM. Perceptions and utilization of palliative care services in acute care hospitals. J Palliat Med. 2007;10(1):99–110.

    Article  PubMed  Google Scholar 

  23. Hui D, Elsayem A, De La Cruz M. Cancer centers availability and integration of palliative Care at US. JAMA. 2010;303:1054–61.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Holmenlund K, Sjøgren P, Nordly M. Specialized palliative care in advanced cancer: what is the efficacy? A systematic review. Palliat Support Care. 2017;15(6):724.

    Article  PubMed  Google Scholar 

  25. Hui D, Bansal S, Strasser F, Morita T, Caraceni A, Davis M, et al. Indicators of integration of oncology and palliative care programs: an international consensus. Ann Oncol. 2015;26(9):1953–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Higginson IJ, Evans CJ. What is the evidence that palliative care teams improve outcomes for cancer patients and their families? Cancer J. 2010 Sep–Oct;16(5):423–35.

    Article  PubMed  Google Scholar 

  27. Ferrell B, Sun V, Hurria A, Cristea M, Raz DJ, Kim JY, et al. Interdisciplinary palliative care for patients with lung cancer. J Pain Symptom Manag. 2015;50(6):758–67.

    Article  Google Scholar 

  28. Hanks G, Robbins M, Sharp D, Forbes K, Done K, Peters T, et al. The imPaCT study: a randomised controlled trial to evaluate a hospital palliative care team. Br J Cancer. 2002;87(7):733–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Temel J, Greer J, Pirl W. Early palliative care in non-small-cell lung cancer. N Engl J Med. 2010;363(23):2264–5.

    CAS  Google Scholar 

  30. Temel JS, Greer JA, Admane S, Gallagher ER, Jackson VA, Lynch TJ, et al. Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non–small-cell lung cancer: Results of a randomized study of early palliative care. J Clin Oncol. 2011;29(17):2319–26.

    Article  PubMed  Google Scholar 

  31. Zimmermann C, Swami N, Krzyzanowska M, Hannon B, Leighl N, Oza A, et al. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet. 2014;383(9930):1721–30.

    Article  PubMed  Google Scholar 

  32. Rabow MW, Dibble SL, Pantilat SZ, McPhee SJ. The comprehensive care team: a controlled trial of outpatient palliative medicine consultation. Arch Intern Med. 2004;164(1):83–91.

    Article  PubMed  Google Scholar 

  33. Scibetta C, Kerr K, Mcguire J, Rabow MW. The costs of waiting: implications of the timing of palliative care consultation among a cohort of decedents at a comprehensive cancer center. J Palliat Med. 2016;19(1):69–75.

    Article  PubMed  Google Scholar 

  34. Wentlandt K, Krzyzanowska MK, Swami N, Rodin GM, Le LW, Zimmermann C. Referral practices of oncologists to specialized palliative care. J Clin Oncol. 2012;30(35):4380–6.

    Article  PubMed  Google Scholar 

  35. Reyes-Ortiz CA, Williams C, Westphal C. Comparison of early versus late palliative care consultation in end-of-life care for the hospitalized frail elderly patients. Am J Hospice Palliat Med. 2015;32(5):516–20.

    Article  Google Scholar 

  36. Bakitas M, Lyons KD, Hegel MT, Balan S, Brokaw FC, Seville J, et al. Effects of a palliative care intervention on clinical outcomes in patients with advanced cancer: the Project ENABLE II randomized controlled trial. JAMA. 2009;302(7):741–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Cassel JB, Kerr KM, Kalman NS, Smith TJ. The business case for palliative care: translating research into program development in the US. J Pain Symptom Manag. 2015;50(6):741–9.

    Article  Google Scholar 

  38. Smith S, Brick A, O’Hara S, Normand C. Evidence on the cost and cost-effectiveness of palliative care: a literature review. Palliat Med. 2014;28(2):130–50.

    Article  PubMed  Google Scholar 

  39. Gade G, Venohr I, Conner D, McGrady K, Beane J, Richardson RH, et al. Impact of an inpatient palliative care team: a randomized controlled trial. J Palliat Med. 2008;11(2):180–90.

    Article  PubMed  Google Scholar 

  40. Walter L, Schonberg M, Francisco S, Medical H, Israel B, Medical D. Screening mammography in older women: a review. JAMA. 2014;311:1336–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Wildiers H, Heeren P, Puts M, Topinkova E, Janssen-Heijnen ML, Extermann M, et al. International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol. 2014 Aug;32(24):2595–603.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Schiphorst A, Ten Bokkel HD, Breumelhof R, Burgmans J, Pronk A, Hamaker M. Geriatric consultation can aid in complex treatment decisions for elderly cancer patients. Eur J Cancer Care. 2016;25(3):365–70.

    Article  CAS  Google Scholar 

  43. Sattar S, Alibhai SM, Spoelstra SL, Fazelzad R, Puts MT. Falls in older adults with cancer: a systematic review of prevalence, injurious falls, and impact on cancer treatment. Support Care Cancer. 2016;24(10):4459–69.

    Article  PubMed  Google Scholar 

  44. Mohile SG, Mohamed MR, Culakova E, Xu H, Loh KP, Magnuson A, et al. A geriatric assessment (GA) intervention to reduce treatment toxicity in older patients with advanced cancer: a University of Rochester Cancer Center NCI community oncology research program cluster randomized clinical trial (CRCT). J Clin Oncol. 2020;38(15):12009.

    Article  Google Scholar 

  45. Davies E, Higginson IJ, World Health Organization. Better palliative care for older people. 2004.

    Google Scholar 

  46. Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–57.

    Article  CAS  PubMed  Google Scholar 

  47. Pal LM, Manning L. Palliative care for frail older people. Clin Med (Lond). 2014 Jun;14(3):292–5.

    Article  Google Scholar 

  48. Koller K, Rockwood K. Frailty in older adults: implications for end-of-life care. Cleve Clin J Med. 2013 Mar;80(3):168–74.

    Article  PubMed  Google Scholar 

  49. Gallagher P, Baeyens J, Topinkova E, Madlova P, Cherubini A, Gasperini B, et al. Inter-rater reliability of STOPP (Screening Tool of Older Persons’ Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) criteria amongst physicians in six European countries. Age Ageing. 2009;38(5):603–6.

    Article  PubMed  Google Scholar 

  50. Alexander K, Goldberg J, Korc-Grodzicki B. Palliative care and symptom management in older patients with cancer. Clin Geriatr Med. 2016;32(1):45–62.

    Article  PubMed  Google Scholar 

  51. Haley WE. Family caregivers of elderly patients with cancer: understanding and minimizing the burden of care. J Support Oncol. 2003 Nov–Dec;1(4 Suppl 2):25–9.

    PubMed  Google Scholar 

  52. Lunney JR, Lynn J, Foley DJ, Lipson S, Guralnik JM. Patterns of functional decline at the end of life. JAMA. 2003;289(18):2387–92.

    Article  PubMed  Google Scholar 

  53. Nagy-Agren S, Haley HB. Management of infections in palliative care patients with advanced cancer. J Pain Symptom Manag. 2002;24(1):64–70.

    Article  Google Scholar 

  54. Albrecht JS, McGregor JC, Fromme EK, Bearden DT, Furuno JP. A nationwide analysis of antibiotic use in hospice care in the final week of life. J Pain Symptom Manag. 2013;46(4):483–90.

    Article  Google Scholar 

  55. Kelechi TJ, Prentice M, Madisetti M, Brunette G, Mueller M. Palliative care in the management of pain, odor, and exudate in chronic wounds at the end of life: a cohort study. J Hospice Palliat Nurs. 2017;19(1):17–25.

    Article  Google Scholar 

  56. Hui D, Dev R, Bruera E. The last days of life: symptom burden and impact on nutrition and hydration in cancer patients. Curr Opin Support Palliat Care. 2015;9(4):346.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Lichtman SM. Guidelines for the treatment of elderly cancer patients. Cancer Control. 2003;10(6):445–53.

    Article  PubMed  Google Scholar 

  58. Baker SD, Grochow LB. Pharmacology of cancer chemotherapy in the older person. Clin Geriatr Med. 1997;13(1):169–83.

    Article  CAS  PubMed  Google Scholar 

  59. Agrawal A, Asthana V, Sharma JP, Gupta V. Efficacy of lipophilic vs lipophobic opioids in addition to hyperbaric bupivacaine for patients undergoing lower segment caeserean section. Anesth Essays Res. 2016 Sep–Dec;10(3):420–4.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Smith HS. Opioid metabolism. Mayo Clinic Proc. 2009;84(7):613–24.

    Article  CAS  Google Scholar 

  61. Overholser BR, Foster DR. Opioid pharmacokinetic drug-drug interactions. Am J Manag Care. 2011 Sep;17(Suppl 11):S276–87.

    PubMed  Google Scholar 

  62. Ilene Browner MD. Applications in Geriatric Oncology. 2020; Available at: https://www.hopkinsmedicine.org/gec/series/cancer_aging.html. Accessed 23 August 2020.

  63. Weinstein JR, Anderson S. The aging kidney: physiological changes. Adv Chronic Kidney Dis. 2010;17(4):302–7.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Pruskowski J, Arnold RM. Opioid pharmacokinetics# 307. J Palliat Med. 2016;19(6):668–70.

    Article  PubMed  Google Scholar 

  65. Malec M, Shega JW. Pain management in the elderly. Med Clin North Am. 2015 Mar;99(2):337–50.

    Article  PubMed  Google Scholar 

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Mohanaselvan, A., Paulino, R., Wieland, L., Subbiah, I., Holmes, H.M. (2022). Palliative Care in Older Adults with Cancer and Frailty. In: Gomes, F. (eds) Frailty in Older Adults with Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-89162-6_15

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  • DOI: https://doi.org/10.1007/978-3-030-89162-6_15

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