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Staging of pancreatic cancer with multidetector CT in the setting of preoperative chemoradiation therapy

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An Erratum to this article was published on 25 February 2011

Abstract

Background

Preoperative chemoradiation can potentially improve outcomes in patients with pancreatic cancer. This study addresses its effect on staging pancreatic cancer with multidetector computed tomography (MDCT).

Methods

Fifty-five patients underwent a dual-phase MDCT pancreas protocol for proved pancreatic cancer. Of these, 16 patients underwent preoperative chemoradiation. Three radiologists independently reviewed images to assess for locally advanced disease, liver and peritoneal metastases on baseline studies of all 55 patients, and on follow-up preoperative studies for the 16 patients receiving preoperative therapy. Overall score for resectability was graded on a scale from 1 to 5 (1, definitely resectable; 5. definitely unresectable). Receiver operating characteristic curves and weighted (κ statistics were determined.

Results

The areas under the receiver operating characteristic curves for readers 1, 2, and 3 were 0.98, 0.96, and 0.90, respectively. Weighted κ values for reader 1 versus reader 2, reader 1 versus reader 3, and reader 2 versus reader 3 were 0.90, 0.57, and 0.54, respectively. Interpreting scores of 1 to 3 for resectability as resectable disease, the mean values for sensitivity, specificity, negative predictive value, positive predictive value, and accuracy were 0.92, 0.91, 0.74, 0.98, and 0.92 respectively.

Conclusion

The negative predictive value for MDCT for identifying unresectable pancreatic cancer in the setting of preoperative therapy is comparable to that reported in the absence of neoadjuvant therapy.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 57, Houston, Texas, 77070, USA

    E. P. Tamm, E. M. Loyer, S. Faria, R. A. Dubrow & C. Charnsangavej

  2. Department of Surgical Oncology, Unit 444, The University of Texas M.D. Anderson Cancer Center, 301402, Houston, Texas, 77230, USA

    C. P. Raut & D. B. Evans

  3. Department of Oncologic Medicine, Unit 426, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, Texas, 77030, USA

    R. A. Wolff

  4. Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 97, Houston, Texas, 77030, USA

    C. H. Crane

Authors
  1. E. P. Tamm
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  2. E. M. Loyer
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  3. S. Faria
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  4. C. P. Raut
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  5. D. B. Evans
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  6. R. A. Wolff
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  7. C. H. Crane
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  8. R. A. Dubrow
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  9. C. Charnsangavej
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Corresponding author

Correspondence to E. P. Tamm.

Additional information

An erratum to this article can be found online at http://dx.doi.org/10.1007/s00261-011-9702-4

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Tamm, E.P., Loyer, E.M., Faria, S. et al. Staging of pancreatic cancer with multidetector CT in the setting of preoperative chemoradiation therapy. Abdom Imaging 31, 568–574 (2006). https://doi.org/10.1007/s00261-005-0194-y

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  • DOI: https://doi.org/10.1007/s00261-005-0194-y

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