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Sentinel Node Mapping in Endometrial Cancer

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Recent Advances in Endometrial Cancer

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Abstract

Knowledge about the lymph node involvement in endometrial cancer is essential for prognostication and tailoring adjuvant therapies. Sentinel node assessment is an alternative to complete lymphadenectomy, which while minimizing surgical and postoperative morbidity, can give an accurate estimation about the lymph nodal involvement. In this chapter, we describe how sentinel node mapping evolved in endometrial cancer, various mapping techniques used, present role of sentinel node mapping, oncological outcomes when sentinel node mapping is used and also the controversies surrounding sentinel mapping.

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References

  1. Holloway RW, Abu-Rustam NR, Backes FJ, Boggess JF, Gotlieb WH, Jeffrey Lowery W, et al. Sentinel lymph node mapping and staging in endometrial cancer: a Society of Gynecologic Oncology literature review with consensus recommendation. Gynecol Oncol. 2017 August;146(2):405–15.

    PubMed  PubMed Central  Google Scholar 

  2. Shepherd JH. Revised FIGO staging for gynaecological cancer. Br J Obstet Gynaecol. 1989;96:889–92.

    CAS  PubMed  Google Scholar 

  3. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Obstet Gynaecol. 2009;105:103–4.

    Google Scholar 

  4. Creasmen WT, Morrow CP, Bundy BN, et al. Surgical pathologic spread pattern of endometrial cancer. A Gynecologic Oncology Group Study. Cancer. 1987;60(8 Suppl):2035–41.

    Google Scholar 

  5. Orr JW, Holloway RW, Orr PF, Holimon JL. Surgical staging of uterine cancer: an analysis of perioperative morbidity. Gynecol Oncol. 1991;42:209–16.

    PubMed  Google Scholar 

  6. Creasmen WT, Odicino F, Maisonneuve P, et al. Carcinoma of the corpus uteri. J Epidemiol Biostat. 2001;6:47–86.

    Google Scholar 

  7. Zivanovic O, Khoury-Collado F, Abu-Rustam NR, Germignani ML. Sentinel lymph node biopsy in the management of vulvar carcinoma, cervical carcinoma, and endometrial cancer. Oncologist. 2009;14:695–705.

    PubMed  Google Scholar 

  8. National Comprehensive Cancer Network. Uterine neoplasms (Version 2.2018). 2018. Available from http://www.nccn.org/professionals/physician_gls/pdf/uterine.pdf

  9. Abu-Rustam NR, Khory-Collado F, Pandit-Taskar N, et al. Sentinel lymph node mapping for grade 1 endometrial cancer: is it the answer to the surgical staging dilemma? Gynecol Oncol. 2009;113:163–9.

    Google Scholar 

  10. Abu-Rustam NR. Sentinel lymph node mapping for endometrial cancer: a modern approach to surgical staging. JNCCN. 2014;12(2):288–97.

    Google Scholar 

  11. Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Ann Oncol. 2016;27:16–41.

    CAS  PubMed  Google Scholar 

  12. Press JZ, Gotlieb WH. Controversies in the treatment of early stage endometrial cancer. Obstet Gynecol Int. 2012;2012:578490.

    PubMed  PubMed Central  Google Scholar 

  13. Beesley VL, Rowlands IJ, Hayes SC, Janda M, O’ Rourke P, Marquart L, et al. Incidence, risk factors and estimates of a woman’s risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in a women treated for endometrial cancer. Gynecol Oncol. 2015;136:87–93.

    PubMed  Google Scholar 

  14. Zikan M, Fischerova D, Pinkavova I, Slama J, Weinberger V, Dusek L, et al. A prospective study examining the incidence of asymptomatic and symptomatic lymphoceles following lymphadenectomy in patients with gynaecological cancer. Gynecol Oncol. 2015;137:291–8.

    PubMed  Google Scholar 

  15. Abu-Rustam NR, Alektiar K, Iasonos A, et al. The incidence of symptomatic lower-extremity lymphedema following treatment of uterine corpus malignancies: a 12-year experience at memorial Sloan-Kettering cancer Centre. Gynecol Oncol. 2006;103:714–8.

    Google Scholar 

  16. Panici PB, Basile S, Maneschi F, et al. Systematic pelvic lymphadenectomy in early-stage endometrial cancer: a randomized clinical trial. J Natl Cancer Inst. 2008;100:1707–16.

    Google Scholar 

  17. ASTEC study group, Kitchener H, Swart AM, Qian Q, et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomized study. Lancet. 2009;373:125–36.

    Google Scholar 

  18. Todo Y, Kato H, Kaneuchi M, et al. Survival effect of Para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective analysis. Lancet. 2010;375:1165–72.

    PubMed  Google Scholar 

  19. Frumovitz M, Slomovitz BM, Singh DK, Broaddus RR, Abrams J, Sun CC, et al. Frozen section analysis as predictors of lymphatic spread in patients with early-stage uterine cancer. J Am Coll Surg. 2004;199:388–93.

    PubMed  Google Scholar 

  20. Mariani A, Dowdy SC, Cliby WA, Gostout BS, Jones MB, Wilson TO, et al. Prospective assessment of lymphatic dissemination in endometrial cancer: a paradigm shift in surgical staging. Gynecol Oncol. 2008;109:11–8.

    PubMed  PubMed Central  Google Scholar 

  21. Case AS, Rocconi RP, Straughn JM, Conner M, Novak L, Wang W, et al. A prospective blinded evaluation of the accuracy of frozen section for the surgical management of endometrial cancer. Obstet Gynecol. 2006;108:1375–9.

    PubMed  Google Scholar 

  22. Kumar S, Bandyopadhyay S, Semaan A, Shah JP, Mahdi H, Morris R, et al. The role of frozen section in surgical staging of low risk endometrial cancer. PLoS One. 2011;6:e21912.

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Altman AD, Ferguson SE, Atenafu EG, Kobel M, McAlpine JN, Panzarella T, et al. Canadian high risk endometrial cancer (CHREC) consortium: analyzing the clinical behavior of high risk endometrial cancers. Gynecol Oncol. 2015;139:268–74.

    PubMed  Google Scholar 

  24. Kumar S, Medeiros F, Dowdy SC, Keeney GL, Bakkum-Gamez JN, Podratz KC, et al. A prospective assessment of the reliability of frozen section to direct intraoperative decision making in endometrial cancer. Gynecol Oncol. 2012;127:525–31.

    PubMed  Google Scholar 

  25. Stephan JM, Hansen J, Samuelson M, McDonald M, Chin Y, Bender D, et al. Intra-operative frozen section results reliably predict final pathology in endometrial cancer. Gynecol Oncol. 2014;133:499–505.

    PubMed  Google Scholar 

  26. Cabanas RM. An approach for the treatment of penile carcinoma. Cancer. 1977;39:456–66.

    CAS  PubMed  Google Scholar 

  27. Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992;127:392–9.

    CAS  PubMed  Google Scholar 

  28. Krag DN, Anderson SJ, Julian TB, Brown AM, Harlow SP, Costantino JP, et al. Sentinel lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial. Lancet Oncol. 2010;11:927–33.

    PubMed  PubMed Central  Google Scholar 

  29. Oonk MH, van Hemel BM, Hollema H, de Hullu JA, Ansink AC, Vergote I, et al. Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol. 2010;11:646–52.

    PubMed  Google Scholar 

  30. Burke TW, Levenback C, Tornos C, Morris M, Wharton JT, Gerhenson DM. Intraabdominal lymphatic mapping to direct selective pelvic and par-aortic lymphadenectomy in women with high-risk endometrial cancer: results of a pilot study. Gynecol Oncol. 1996;62:169–73.

    CAS  PubMed  Google Scholar 

  31. National Comprehensive Cancer Network. Vulvar cancer (Version 1.2019). 2018. Available from: http://www.nccn.org/professionals/physician_gls/pdf/vulvar.pdf

  32. National Comprehensive Cancer Network. Cervical cancer (Version 1.2019). 2018. Available from: http://www.nccn.org/professionals/physician_gls/pdf/cervical.pdf

  33. Barlin JN, Khoury-Collado F, Kim CH, Leitao MM, Chi DS, Sonodo Y, et al. The importance of applying a sentinel lymph node mapping algorithm in endometrial cancer staging: beyond removal of blue nodes. Gynecol Oncol. 2012;125(3):531–5.

    PubMed  Google Scholar 

  34. Sinno AK, Fader AN, Tanner EJ. Single site robotic sentinel lymph node biopsy and hysterectomy in endometrial cancer. Gynecol Oncol. 2015;137(1):190.

    PubMed  Google Scholar 

  35. Sinno AK, Fader AN, Roche KL, Giuntoli RL II, Tanner EJ. A comparison of colorimetric versus fluorometric sentinel lymph node mapping during robotic surgery for endometrial cancer. Gynecol Oncol. 2014;134(2):281–6.

    PubMed  Google Scholar 

  36. Torne A, Pahisa J, Vidal-Sicart S, Martinez-Roman S, Paredes P, Puerto B, et al. Transvaginal ultrasound-guided myometrial injection of radiotracer (TUMIR): a new method for sentinel lymph node detection in endometrial cancer. Gynecol Oncol. 2013;128(1):88–94.

    PubMed  Google Scholar 

  37. Solima E, Martinelli F, Ditto A, Maccauro M, Carcangiu M, Mariani L, et al. Diagnostic accuracy of sentinel node in endometrial cancer by using hysteroscopic injection of radiolabeled tracer. Gynecol Oncol. 2012;126(3):419–23.

    PubMed  Google Scholar 

  38. Niikura H, Kaiho-Sakuma M, Tokunaga H, Toyoshima M, Utsunomiya H, Nagase S, et al. Tracer injection sites and combinations for sentinel lymph node detection in patients with endometrial cancer. Gynecol Oncol. 2013;131:299–303.

    PubMed  Google Scholar 

  39. Rossi EC, Jackson A, Ivanova A, Boggess JF. Detection of sentinel nodes for endometrial cancer with robotic assisted fluorescence imaging: cervical versus hysteroscopic injection. Int J Gynecol Cancer. 2013;23:1704–11.

    PubMed  Google Scholar 

  40. Holloway RW, Ahmad S, Kendrick JE, Bigsby GE, Brudie LA, Ghurani GB, et al. A prospective cohort study comparing colorimetric and fluorescent imaging for sentinel lymph node mapping in endometrial cancer. Ann Surg Oncol. 2017;24(7):1972–9. https://doi.org/10.1245/s10434-017-5825-3.

    Article  PubMed  Google Scholar 

  41. Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, et al. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study. Lancet Oncol. 2017;18:384–92.

    PubMed  Google Scholar 

  42. Kang S, Yoo HJ, Hwang JH, Lim M-C, Seo S-S, Park S-Y. Sentinel lymph node biopsy in endometrial cancer: meta-analysis of 26 studies. Gynecol Oncol. 2012;126(3):419–23.

    Google Scholar 

  43. Kushner DM, Connor JP, Wilson MA, Hafez GR, Chappell RJ, Stewart SL, et al. Laparoscopic sentinel lymph node mapping for cervix cancer - a detailed evaluation and time analysis. Gynecol Oncol. 2007;106:507–12.

    PubMed  Google Scholar 

  44. Albo D, Wayne JD, Hunt KK, Rahlfs TF, Singletary SE, Ames FC, et al. Anaphylactic reactions to isosulfan blue dye during sentinel lymph node biopsy for breast cancer. Am J Surg. 2001;182:393–8.

    CAS  PubMed  Google Scholar 

  45. Blessing WD, Stolier AJ, Teng SC, Bolton JS, Fuhrman GM. A comparison of methylene blue and lymphazurin in breast cancer sentinel node mapping. Am J Surg. 2002;184:341–5.

    PubMed  Google Scholar 

  46. Levenback C, Ali S, Coleman RL, Gold MA, Fowler JM, Judson PL, et al. Lymphatic mapping and sentinel lymph node biopsy in women with squamous cell carcinoma of the vulva: a gynecologic oncology group study. J Clin Oncol. 2012;30:3786–91.

    PubMed  PubMed Central  Google Scholar 

  47. Veronesi U, Paganelli G, Viale G, Luini A, Zurrida S, Galimberti V, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349:546–53.

    PubMed  Google Scholar 

  48. Gipponi M, Di Somma C, Peressini A, Solari N, Gliori S, Nicolo G, et al. Sentinel lymph node biopsy in patients with stage I/II melanoma: clinical experience and literature review. J Surg Oncol. 2004;85:133–40.

    PubMed  Google Scholar 

  49. Ballester M, Dubernard G, Lecuru F, Heitz D, Mathevet P, Marret H, et al. Detection rate and diagnostic accuracy of sentinel-node biopsy in early stage endometrial cancer: a prospective multicentre study (SENTI-ENDO). Lancet Oncol. 2011;12:469–76.

    PubMed  Google Scholar 

  50. Perissinotti A, Paredes P, Vidal-Sicart S, Torne A, Albela S, Navales I, et al. Use of SPECT/CT for improved sentinel lymph node localization in endometrial cancer. Gynecol Oncol. 2013;129:42–8.

    CAS  PubMed  Google Scholar 

  51. Jewell EL, Huang JJ, Abu-Rustum NR, Gardner GJ, Brown CL, Sonoda Y, et al. Detection of sentinel lymph nodes in minimally invasive surgery using indocyanine green and near-infrared fluorescence imaging for uterine and cervical malignancies. Gynecol Oncol. 2014;133:274–7.

    PubMed  PubMed Central  Google Scholar 

  52. Rossi EC, Ivanova A, Boggess JF. Robotically assisted fluorescence-guided lymph node mapping with ICG for gynecologic malignancies: a feasibility study. Gynecol Oncol. 2012;124:78–82.

    PubMed  Google Scholar 

  53. Papadia A, Buda A, Gasparri ML, Martino GD, Bussi B, Verri D, et al. The impact of different doses of indocyanine green on the sentinel lymph-node mapping in early stage endometrial cancer. J Can Res & Clin Oncol. 2018;144:2187–91.

    CAS  Google Scholar 

  54. Frumovitz M, Plante M, Lee PS, Sandadi S, Lilija JF, Escobar PF, et al. Near-infrared fluorescence for detection of sentinel lymph node in women with cervical and uterine cancers (FILM): a randomised, phase 3, multicentre, non-inferiority trial. Lancet Oncol. 2018;19:1394–403.

    PubMed  PubMed Central  Google Scholar 

  55. Cochran AJ. Prediction of outcome for patients with cutaneous melanoma. Pigment Cell Res. 1997;10:162–7.

    CAS  PubMed  Google Scholar 

  56. Compton CC, Byrd DR, Garcia-Aguilar J, Kurtzman SH, Olawaiye A, Washington MK. AJCC cancer staging atlas. New York, NY: Springer; 2012.

    Google Scholar 

  57. Kim CH, Soslow RA, Park KJ, Barber EL, Khoury-Collado F, Barlin JN, et al. Pathologic ultrastaging improves micrometastasis detection in sentinel lymph nodes during endometrial cancer staging. Int J Gynecol Cancer. 2013;23(5):964–70.

    PubMed  PubMed Central  Google Scholar 

  58. Raimond E, Ballester M, Hudry D, Bendifallah S, Darai E, Graesslin O, et al. Impact of sentinel lymph node biopsy on the therapeutic management of early stage endometrial cancer: results of a retrospective multicentre study. Gynecol Oncol. 2014;133(3):506–11.

    PubMed  Google Scholar 

  59. Touhami O, Trinh XB, Gregoire J, Sebastianelli A, Renaud MC, Grondin K, et al. Predictors of non-sentinel lymph node (non-SLN) metastasis in patients with sentinel lymph node (SLN) metastasis in endometrial cancer. Gynecol Oncol. 2015;138:41–5.

    PubMed  Google Scholar 

  60. Tanner EJ, Sinno AK, Stone RL, Levinson KL, Long KC, Fader AN. Factors associated with successful bilateral sentinel lymph node mapping in endometrial cancer. Gynecol Oncol. 2015;138:542–7.

    PubMed  Google Scholar 

  61. Bats AS, Mathevet P, Buenerd A, Orliaguet I, Mery E, Zerdoud S, et al. The sentinel node technique detects unexpected drainage pathways and allows nodal ultrastaging in early cervical cancer: insights from the multicenter prospective SENTICOL study. Ann Surg Oncol. 2013;20:413–22.

    PubMed  Google Scholar 

  62. Delaloye JF, Pampallona S, Chardonnens E, Fiche M, Lehr HA, De Grandi P, et al. Intraoperative lymphatic mapping and sentinel node biopsy using hysteroscopy in patients with endometrial cancer. Gynecol Oncol. 2007;106:89–93.

    PubMed  Google Scholar 

  63. Desai PH, Hughes P, Tobias DH, Tchabo N, Heller PB, Dise C, et al. Accuracy of robotic sentinel lymph node detection (RSLND) for patients with endometrial cancer (EC). Gynecol Oncol. 2014;135:196–200.

    PubMed  Google Scholar 

  64. Favero G, Pfiffer T, Ribeiro A, Carvalho JP, Baracat EC, Mechsner S, et al. Laparoscopic sentinel lymph node detection after hysteroscopic injection of technetium-99 in patients with endometrial cancer. Int J Gynecol Cancer. 2015;25:423–30.

    PubMed  Google Scholar 

  65. How J, Gotlieb WH, Press JZ, Abitbol J, Pelmus M, Ferenczy A, et al. Comparing indocyanine green, technetium, and blue dye for sentinel lymph node mapping in endometrial cancer. Gynecol Oncol. 2015;137:436–42.

    CAS  PubMed  Google Scholar 

  66. How J, Lau S, Press J, Ferenczy A, Pelmus M, Stern J, et al. Accuracy of sentinel lymph node detection following intra-operative cervical injection for endometrial cancer: a prospective study. Gynecol Oncol. 2012;127:332–7.

    PubMed  Google Scholar 

  67. Lopes LA, Nicolau SM, Baracat FF, Baracat EC, Goncalves WJ, Santos HV, et al. Sentinel lymph node in endometrial cancer. Int J Gynecol Cancer. 2007;17:1113–7.

    CAS  PubMed  Google Scholar 

  68. Lopez-De la Manzanara Cano C, Cordero Garcia JM, Martin-Francisco C, Pascual-Ramirez J, Parra CP, Cespedes Casas C. Sentinel lymph node detection using 99mTc combined with methylene blue cervical injection for endometrial cancer surgical management: a prospective study. Int J Gynecol Cancer. 2014;24:1048–53.

    PubMed  Google Scholar 

  69. Mais V, Peiretti M, Gargiulo T, Parodo G, Cirronis MG, Melis GB. Intraoperative sentinel lymph node detection by vital dye through laparoscopy or laparotomy in early endometrial cancer. J Surg Oncol. 2010;101:408–12.

    PubMed  Google Scholar 

  70. Plante M, Touhami O, Trinh XB, Renaud MC, Sebastianelli A, Grondin K, et al. Sentinel node mapping with indocyanine green and endoscopic near-infrared fluorescence imaging in endometrial cancer. A pilot study and review of the literature. Gynecol Oncol. 2015;137:443–7.

    PubMed  Google Scholar 

  71. Robova H, Charvat M, Strnad P, Hrehorcak M, Taborska K, Skapa P, et al. Lymphatic mapping in endometrial cancer: comparison of hysteroscopic and subserosal injection and the distribution of sentinel lymph nodes. Int J Gynecol Cancer. 2009;19:391–4.

    PubMed  Google Scholar 

  72. Sawicki S, Lass P, Wydra D. Sentinel lymph node biopsy in endometrial cancer: comparison of 2 detection methods. Int J Gynecol Cancer. 2015;25:1044–50.

    PubMed  Google Scholar 

  73. Vidal F, Leguevaque P, Motton S, Delotte J, Ferron G, Querleu D, et al. Evaluation of the sentinel lymph node algorithm with blue dye labeling for early-stage endometrial cancer in a multicentric setting. Int J Gynecol Cancer. 2013;23:1237–43.

    PubMed  Google Scholar 

  74. Li B, Li XG, Wu LY, Zhang WH, Li SM, Min C. A pilot study of sentinel lymph node identification in patients with endometrial cancer. Bull Cancer. 2007;94:E1–4.

    PubMed  Google Scholar 

  75. Mucke J, Klapdor R, Schneider M, Langer F, Gratz KF, Hillemanns P. Isthmocervical labelling and SPECT/CT for optimized sentinel detection in endometrial cancer: technique, experience and results. Gynecol Oncol. 2014;134:287–92.

    CAS  PubMed  Google Scholar 

  76. Khoury-Collado F, Glaser GE, Zivanovic O, Sonoda Y, Levine DA, Chi DS, et al. Improving sentinel lymph node detection rates in endometrial cancer: how many cases are needed? Gynecol Oncol. 2009;115:453–5.

    PubMed  Google Scholar 

  77. Holloway RW, Gupta S, Stavitzski NM, Zhu X, Takimoto EL, Gubbi A, et al. Sentinel lymph node mapping with staging lymphadenectomy for patients with endometrial cancer increases the detection of metastasis. Gynecol Oncol. 2016;141:206–10.

    PubMed  Google Scholar 

  78. Leitao MM, Khoury-Collado F, Gardner G, Sonoda Y, Brown CL, Alektiar KM, et al. Impact of incorporating an algorithm that utilizes sentinel lymph node mapping during minimally invasive procedures on the detection of stage IIIC endometrial cancer. Gynecol Oncol. 2013;129:38–41.

    PubMed  Google Scholar 

  79. Rajanbabu A, Agarwal R. A prospective evaluation of the sentinel node mapping algorithm in endometrial cancer and correlation of its performance against endometrial cancer risk subtypes. Eur J Obstet Gynecol Reprod Biol. 2018;224:77–80.

    PubMed  Google Scholar 

  80. Ducie JA, Eriksson AGZ, Ali N, McGree ME, Weaver AL, Bogani G, et al. Comparison of a sentinel lymph node mapping algorithm and comprehensive lymphadenectomy in the detection of stage IIIC endometrial carcinoma at higher risk for nodal disease. Gynecol Oncol. 2017;147:541–8.

    PubMed  Google Scholar 

  81. Soliman P, Westin S, Dioun S, Sun C, Euscher E, Munsell M, et al. Sentinel lymph node mapping accurately identifies positive nodes in women with high risk endometrial cancer: a prospective validation trial. Int J Gynecol Cancer. 2016;26(Suppl.3):68.

    Google Scholar 

  82. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Uterine Neoplasms, Version 1.2017. 2016.

    Google Scholar 

  83. How J, Farrell PO, Amajoud Z, Lau S, Salvador S, How M, et al. Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis. Minerva Ginecol. 2018;70(2):194–214.

    PubMed  Google Scholar 

  84. Bodurtha SAJ, Fader AN, Tanner EJ. Sentinel lymph node assessment in endometrial cancer: a systematic review and meta-analysis. Am J Obstet Gynecol. 2017;216(5):459–76. e10

    Google Scholar 

  85. Abu-Rustum NR, Khoury-Collado F, Pandit-Taskar N, Soslow RA, Dao F, Sonoda Y, et al. Sentinel lymph node mapping for grade 1 endometrial cancer: is it the answer to the surgical staging dilemma? Gynecol. Oncologia. 2009;113:163–9.

    Google Scholar 

  86. Schiavone M, Scelzo C, Straight C, Zhou Q, Letiao M, Alektiar K, et al. Survival in patients with serous uterine carcinoma undergoing sentinel lymph node mapping. Int J Gynecol Cancer. 2016;26:74–5.

    Google Scholar 

  87. Schiavone M, Scelzo C, Straight C, Zhou Q, Alektiar K, Makker V, et al. Survival of patients with serous uterine carcinoma undergoing sentinel lymph node mapping. Ann Surg Oncol. 2017;24:1965–71.

    PubMed  PubMed Central  Google Scholar 

  88. How J, Gauthier C, Abitbol J, Lau S, Salvador S, Gotlieb R, et al. Impact of sentinel lymph node mapping on recurrence patterns in endometrial cancer. Gynecol Oncol. 2017;144:503–9.

    PubMed  Google Scholar 

  89. How J, Boldeanu I, Lau S, Salvador S, How E, Gotlieb R, et al. Unexpected locations of sentinel lymph nodes in endometrial cancer. Gynecol Oncol. 2017;147(1):18–23.

    PubMed  Google Scholar 

  90. Zahl Eriksson AG, Ducie J, Ali N, McGree ME, Weaver AL, Bogani G, et al. Comparison of a sentinel lymph node and a selective lymphadenectomy algorithm in patients with endometrioid endometrial carcinoma and limited myometrial invasion. Gynecol Oncol. 2016;140:394–9.

    PubMed  Google Scholar 

  91. Buda A, Restaino S, Martino GD, Ponti ED, Monterossi G, Dinoi G, et al. The impact of the type of nodal assessment on prognosis in patients with high-intermediate and high-risk ESMO/ESGO/ESTRO group endometrial cancer. A multicentre Italian study. Eur J Surg Oncol. 2018;44:1562–7.

    PubMed  Google Scholar 

  92. Khoury-Collado F, Murray MP, Hensley ML, Sonoda Y, Alektiar KM, Levine DA, et al. Sentinel lymph node mapping for endometrial cancer improves the detection of metastatic disease to regional lymph nodes. Gynecol Oncol. 2011;122:251–4.

    CAS  PubMed  Google Scholar 

  93. Kumar S, Podratz KC, Bakkum-Gamez JN, Dowdy SC, Weaver AL, McGree ME, et al. Prospective assessment of the prevalence of pelvic, paraaortic and high paraaortic lymph node metastasis in endometrial cancer. Gynecol Oncol. 2014;132:38–43.

    PubMed  Google Scholar 

  94. Abu-Rustam NR, Gomez JD, Alektiar KM, et al. The incidence of isolated paraaortic nodal metastasis in surgically staged endometrial cancer patients with negative pelvic lymph nodes. Gynecol Oncol. 2009;115:236–8.

    Google Scholar 

  95. Chiang AJ, Yu KJ, Chao KC, Teng NN. The incidence of isolated Para-aortic nodal metastasis in completely staged endometrial cancer patients. Gynecol Oncol. 2011;121:122–5.

    PubMed  Google Scholar 

  96. Pelosi E, Arena V, Baudino B, Bello M, Giusti M, Gargiulo T, et al. Pre-operative lymphatic mapping and intraoperative sentinel lymph node detection in early stage endometrial cancer. Nucl Med Commun. 2003;24:971–5.

    CAS  PubMed  Google Scholar 

  97. Cormier B, Rozenholc AT, Gotlieb W, Plante M, Giede C. Communities of practice Group of the Society of gynecologic oncology of Canada. Sentinel lymph node procedure in endometrial cancer: a systematic review and proposal for standardization of future research. Gynecol Oncol. 2015;138:478–85.

    PubMed  Google Scholar 

  98. Todo Y, Suzuki Y, Azuma M, Hatanaka Y, Konno Y, Watari H, et al. Ultrastaging of paraortic lymph nodes in stage IIIC1 endometrial cancer: a preliminary report. Gynecol Oncol. 2012;127:532–7.

    PubMed  Google Scholar 

  99. Yabushita H, Shimazu M, Yamada H, Sawaguchi K, Noguchi M, Nakanishi M, et al. Occult lymph node metastases detected by cytokeratin immunohistochemistry predict recurrence in nodenegative endometrial cancer. Gynecol Oncol. 2001;80:139–44.

    CAS  PubMed  Google Scholar 

  100. St Clair CM, Eriksson AG, Ducie JA, Jewell EL, Alektiar KM, Hensley ML, et al. Low-volume lymph node metastasis discovered during sentinel lymph node mapping for endometrial carcinoma. Ann Surg Oncol. 2016;23:1653–9.

    PubMed  Google Scholar 

  101. Lyman GH, Giuliano AE, Somerfield MR, Benson AB, Bodurka DC, Burstein HJ, et al. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol. 2005;23:7703–20.

    PubMed  Google Scholar 

  102. Naoura I, Canlorbe G, Bendifallah S, Ballester M, Darai E. Relevance of sentinel lymph node procedure for patients with high-risk endometrial cancer. Gynecol Oncol. 2015;136(1):60–4.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gynecologic Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala, India

    Anupama Rajanbabu

  2. Department of Gynecologic Oncology, Prakhar cancer Centre, Kanpur, Uttar Pradesh, India

    Reshu Agarwal

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  1. Anupama Rajanbabu
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  2. Reshu Agarwal
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  1. Department of Obstetrics & Gynecology, Babu Jagjivan Ram Memorial Hospital, New Delhi, India

    Sumita Mehta

  2. Obstetrics and Gynecology, UCMS & GTB Hospital, Delhi, India

    Bindiya Gupta

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Rajanbabu, A., Agarwal, R. (2020). Sentinel Node Mapping in Endometrial Cancer. In: Mehta, S., Gupta, B. (eds) Recent Advances in Endometrial Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-15-5317-2_6

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  • DOI: https://doi.org/10.1007/978-981-15-5317-2_6

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