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Pulmonary Surgery for Malignant Disease in Older Adults

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Principles and Practice of Geriatric Surgery

Abstract

Ms. Jones is a 78-year-old female who recently fell in her kitchen, striking her rib cage against the counter. X-rays in the emergency department showed no rib fractures but did reveal an incidental unsuspected lung mass in the middle of the left lung. This led to a CT scan that showed a 2 cm spiculated nodule in the superior segment of the left lower lobe with no mediastinal adenopathy.

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References

  1. US Census Bureau, Population Division. Table 3. Projections of the population by sex and selected age groups for the United States: 2015 to 2060 (NP2014-T3) Release Date: December 2014

    Google Scholar 

  2. US Census Bureau, Population Division. Table 6. Percent distribution of the projected population by selected age groups for the United States: 2015 to 2060 (NP2014-T6). Release Date: December 2014

    Google Scholar 

  3. Arias E, Heron M, Xu JQ (2017) United States life tables, 2014. In: National vital statistics reports, vol 66, no 4. National Center for Health Statistics, Hyattsville

    Google Scholar 

  4. US Census Bureau, Population Division. Table 17. Projected life expectancy at birth by sex, race, and hispanic origin for the United States: 2015 to 2060 (NP2014-T17). Release Date: December 2014

    Google Scholar 

  5. American Cancer Society, Cancer Facts & Figures (2017) Age-adjusted cancer death rates, males by site. http://www.cancer.org/docroot/MED/content/MED_1_1_Most_Requested_Graphs_and_Figures_2008.asp

  6. American Cancer Society, Cancer Facts & Figures (2017) Age-adjusted cancer death rates, females by site. http://www.cancer.org/docroot/MED/content/MED_1_1_Most_Requested_Graphs_and_Figures_2008.asp

  7. Howlader N, Noone AM, Krapcho M, et al. SEER cancer statistics review, 1975–2014. National Cancer Institute. Bethesda. https://seer.cancer.gov/csr/1975_2014/. Based on November 2016 SEER data submission, posted to the SEER web site, April 2017

  8. Gridelli C, Langer C, Maione P, Rossi A, Schild SE (2007) Lung cancer in the elderly. J Clin Oncol 25(14):1898–1907

    Article  PubMed  Google Scholar 

  9. Hage R, de la Riviere AB, Seldenrijk C, van den Bosch JM (2003) Update in pulmonary carcinoid tumors: a review article. Ann Surg Oncol 10(6):697–704

    Article  CAS  PubMed  Google Scholar 

  10. Teeter SM, Holmes FF, McFarlane MJ (1987) Lung carcinoma in the elderly population. Influence of histology on the inverse relationship of stage to age. Cancer 60(6):1331–1336

    Article  CAS  PubMed  Google Scholar 

  11. Rossi A, Ganassini A, Tantucci C et al (1996) Aging and the respiratory system. Aging (Milano) 8(3):143–161

    CAS  Google Scholar 

  12. Janssens JP, Pache JC, Nicod LP (1999) Physiological changes in respiratory function associated with aging. Eur Respir J 13:197–205

    Article  CAS  PubMed  Google Scholar 

  13. Meyer KC (2004) Lung infections and aging. Ageing Res Rev 3(1):55–67

    Article  PubMed  Google Scholar 

  14. Verra F, Escudier E, Lebargy F et al (1995) Ciliary abnormalities in bronchial epithelium of smokers, ex-smokers, and nonsmokers. Am J Respir Crit Care Med 151(3):630–634

    Article  CAS  PubMed  Google Scholar 

  15. Salathe M, O’Riordan TG, Wanner A (1996) Treatment of mucociliary dysfunction. Chest 110:1048–1057

    Article  CAS  PubMed  Google Scholar 

  16. McLesky CH (1992) Anesthesia for the geriatric patient. In: Barash PG, Cullen BF, Staelting RK (eds) Clinical anesthesia, 2nd edn. JB Lippincott, Philadelphia, pp 1353–1383

    Google Scholar 

  17. Fleisher LA, Fleischmann KE, Auerbach AD et al (2014) ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery. Circulation 130:e278–e333

    PubMed  Google Scholar 

  18. Passman RS, Gingold DS, Amar D et al (2005) Prediction rule for atrial fibrillation after major noncardiac thoracic surgery. Ann Thorac Surg 79:1698–1703

    Article  PubMed  Google Scholar 

  19. Roselli EE, Murthy SC, Rice TW et al (2005) Atrial fibrillation complicating lung cancer resection. J Thorac Cardiovasc Surg 130:438–444

    Article  PubMed  Google Scholar 

  20. Sedrakyan A, Treasure T, Browne J et al (2005) Pharmacologic prophylaxis for postoperative atrial tachyarrhythmia in general thoracic surgery: evidence from randomized clinical trials. J Thorac Cardiovasc Surg 129:997–1005

    Article  CAS  PubMed  Google Scholar 

  21. British Thoracic Society, Society of Cardiothoracic Surgeons of Great Britain and Ireland Working Party (2001) Guidelines on the selection of patients with lung cancer for surgery. Thorax 56:89–108

    Article  Google Scholar 

  22. Colice GL, Shafazand S, Griffin JP et al (2007) Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidence-based clinical practice guidelines (2nd ed). Chest 132:161–177

    Article  Google Scholar 

  23. Wyser C, Stulz P, Soler M et al (1999) Prospective evaluation of an algorithm for the functional assessment of lung resection candidates. Am J Respir Crit Care Med 159:1450–1456

    Article  CAS  PubMed  Google Scholar 

  24. Datta D, Lahiri B (2003) Preoperative evaluation of patients undergoing lung resection surgery. Chest 123:2096–2103

    Article  PubMed  Google Scholar 

  25. Linden PA, Bueno R, Colson YL et al (2005) Lung resection in patients with preoperative FEV1 < 35% predicted. Chest 127:1984–1990

    Article  PubMed  Google Scholar 

  26. Ferguson MK, Little L, Rizzo L et al (1988) Diffusing capacity predicts morbidity and mortality after pulmonary resection. J Thorac Cardiovasc Surg 96:894–900

    Article  CAS  PubMed  Google Scholar 

  27. Stephan F, Boucheseiche S, Hollande J et al (2000) Pulmonary complications following lung resection: a comprehensive analysis of incidence and possible risk factors. Chest 118:1263–1270

    Article  CAS  PubMed  Google Scholar 

  28. Botsen PC, Block AJ, Moulder PC (1981) Relationship between preoperative pulmonary function tests and complications after thoracotomy. Surg Gynecol Obstet 52:813–815

    Google Scholar 

  29. Girish M, Trayner E, Dammann O et al (2001) Symptom-limited stair climbing as a predictor of postoperative cardiopulmonary complications after high risk surgery. Chest 120:1147–1151

    Article  CAS  PubMed  Google Scholar 

  30. Solway S, Brooks D, Lacasses Y et al (2001) A qualitative systematic overview of the measurement properties of functional walk tests used in the cardiorespiratory domain. Chest 119(1):256–270

    Article  CAS  PubMed  Google Scholar 

  31. Jaklitsch MT, Mery CM, Audisio RA (2003) The use of surgery to treat lung cancer in elderly patients. Lancet Oncol 4:463–471

    Article  PubMed  Google Scholar 

  32. Olsen GN, Block AJ, Tobias JA (1974) Prediction of postpneumonectomy pulmonary function using quantitative macroaggregate lung scanning. Chest 66:13–16

    Article  CAS  PubMed  Google Scholar 

  33. Pate P, Tenholder MF, Griffin JP et al (1996) Preoperative assessment of the high-risk patient for lung resection. Ann Thorac Surg 61:1494–1500

    Article  CAS  PubMed  Google Scholar 

  34. Markos J, Mullan BP, Hillman DR et al (1989) Preoperative assessment as a predictor of mortality and morbidity after lung resection. Am Rev Respir Dis 139:902–910

    Article  CAS  PubMed  Google Scholar 

  35. Bolliger CT, Wyser C, Boser H et al (1995) Lung scanning and exercise testing for the prediction of postoperative performance in lung resection candidates at increased risk of complications. Chest 108:947–348

    Article  Google Scholar 

  36. Holden DA, Rice TW, Stefmach K et al (1992) Exercise testing, 6-min walk, and stair climb in the evaluation of patients at high risk for pulmonary resection. Chest 102:1774–1779

    Article  CAS  PubMed  Google Scholar 

  37. Wahi R, McMurtry MJ, DeCaro LF et al (1989) Determinants of perioperative morbidity and mortality after pneumonectomy. Ann Thorac Surg 48:33–37

    Article  CAS  PubMed  Google Scholar 

  38. Brock MV, Kim MP, Hooker CM et al (2004) Pulmonary resection in octogenarians with stage I nonsmall cell lung cancer: a 22-year experience. Ann Thorac Surg 77:271–277

    Article  PubMed  Google Scholar 

  39. Moller JT, Cluitmans P, Rasmussen LS et al (1998) Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study. Lancet 351:857–861

    Article  CAS  PubMed  Google Scholar 

  40. Hshieh TT, Saczynski J, Gou RY et al (2017) Trajectory of functional recovery after postoperative delirium in elective surgery. Ann Surg 265:647–653

    Article  PubMed  Google Scholar 

  41. Rasmussen LS, Siersma VD, ISPOCD Group (2004) Postoperative cognitive dysfunction: true deterioration versus random variation. Acta Anesthesiol Scand 48:1137–1143

    Article  CAS  Google Scholar 

  42. Newman S, Stygall J, Shaefi S et al (2007) Postoperative cognitive dysfunction after noncardiac surgery. Anesthesiology 106:572–590

    Article  PubMed  Google Scholar 

  43. Kaneko T, Takahashi S, Naka T et al (1997) Postoperative delirium following gastrointestinal surgery in elderly patients. Surg Today 27:107–111

    Article  CAS  PubMed  Google Scholar 

  44. Fukuse T, Satoda N, Hijiya K et al (2005) Importance of a comprehensive geriatric assessment in prediction of complications following thoracic surgery in elderly patients. Chest 127:886–891

    Article  PubMed  Google Scholar 

  45. Narian O, Rubenstein L et al (1988) Predictors of immediate and 6 month outcomes in hospitalized elderly patients. The importance of functional status. J Am Geriatr Soc 36:775–783

    Article  Google Scholar 

  46. Reuben D, Rubenstein L et al (1992) Value of functional status as a predictor of mortality: results of a prospective study. Am J Med 93(6):663–669

    Article  CAS  PubMed  Google Scholar 

  47. Landi F, Giuseppe G et al (1999) Body mass index and mortality among older people living in the community. J Am Geriatr Soc 47:1072

    Article  CAS  PubMed  Google Scholar 

  48. Audisio RA, Ramesh H, Longo W et al (2005) Preoperative assessment of surgical risk in oncogeriatric patients. Oncologist 10:262–268

    Article  PubMed  Google Scholar 

  49. Rubenstein LZ, Schairer C, Wieland GD, Kane R (1984) Systematic biases in functional status assessment of elderly adults: effects of different data sources. J Gerontol 39(6):686–691

    Article  CAS  PubMed  Google Scholar 

  50. Buccheri G, Ferrigno D, Tamburini M (1996) Karnofsky and ECOG performance status scoring in lung cancer: a prospective, longitudinal study of 536 patients from a single institution. Eur J Cancer 32A(7):1135

    Article  CAS  PubMed  Google Scholar 

  51. Harpole DH Jr, Herndon JF 2nd, Young WG Jr et al (1995) Stage I nonsmall cell lung cancer: a multivariate analysis of treatment methods and patterns of recurrence. Cancer 76:787–796

    Article  PubMed  Google Scholar 

  52. Stamatis G, Djuric D, Eberhardt W et al (2002) Postoperative morbidity and mortality after induction chemoradiotherapy for locally advancer lung cancer: an analysis of 350 operated patients. Eur J Cardiothorac Surg 22:292–297

    Article  PubMed  Google Scholar 

  53. Ferguson MK, Vigneswaran WT (2008) Diffusing capacity predicts morbidity after lung resection in patients without obstructive lung disease. Ann Thorac Surg 85(4):1158–1164

    Article  PubMed  Google Scholar 

  54. O’Rourke MA, Feussner JR, Feigl P et al (1987) Age trends of lung cancer stage at diagnosis: implications for lung cancer screening in the elderly. JAMA 258:921–926

    Article  PubMed  Google Scholar 

  55. Mery CM, Pappas AN, Bueno R et al (2005) Similar long-term survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Chest 128:237–245

    Article  PubMed  Google Scholar 

  56. Weinmann M, Jeremie B, Toomes H et al (2003) Treatment of lung cancer in the elderly. Part I. Non-small cell lung cancer. Lung Cancer 39:233–253

    Article  PubMed  Google Scholar 

  57. Morandi U, Stefani A, Golinelli M et al (1997) Results of surgical resection in patients over the age of 70 years with non small-cell lung cancer. Eur J Cardiothorac Surg 11:432–439

    Article  CAS  PubMed  Google Scholar 

  58. Gail MH, Eagan RT, Feld R et al (1984) Prognostic factors in patients with resected state I non-small cell lung cancer: a report from the Lung Cancer Study Group. Cancer 54:1802–1813

    Article  CAS  PubMed  Google Scholar 

  59. Mountain CF, Lukeman JM, Hammar SP et al (1987) Lung cancer classification: the relationship of disease extent and cell type to survival in a clinical trials population. J Surg Oncol 35:147–156

    Article  CAS  PubMed  Google Scholar 

  60. Deslauriers J, Gregoire J (2000) Surgical therapy of early non-small cell lung cancer. Chest 117(suppl):104S–109S

    Article  CAS  PubMed  Google Scholar 

  61. Faulkner SL (2000) Is Lobectomy the “gold standard” for stage I lung cancer in year 2000? Chest 118(suppl):119S

    Google Scholar 

  62. Bates M (1970) Results of surgery for bronchial carcinoma in patients aged 70 and over. Thorax 25:77–78

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Evans EW (1973) Resection of bronchial carcinoma in the elderly. Thorax 28:86–88

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  64. Kirsh MM, Rotman H, Bove E et al (1976) Major pulmonary resection for bronchial carcinoma in the elderly. Ann Thorac Surg 22:369–373

    Article  CAS  PubMed  Google Scholar 

  65. Harviel JD, McNamara JJ, Straehley CJ (1978) Surgical treatment of lung cancer in patients over the age of 70 years. J Thorac Cardiovasc Surg 75:802–805

    CAS  PubMed  Google Scholar 

  66. Ginsberg RJ, Hill LD, Eagan RT et al (1983) Modern thirty-day operative mortality for surgical resections in lung cancer. J Thorac Cardiovasc Surg 86:654–658

    CAS  PubMed  Google Scholar 

  67. Mery CM, Jaklitch MT (2006) Lung resection in the elderly, correspondence. Chest 129:496–497

    Article  Google Scholar 

  68. Albano WA (1977) Should elderly patients undergo surgery for cancer. Geriatrics 32:105–108

    CAS  PubMed  Google Scholar 

  69. Breyer RH, Zippe C, Pharr WF et al (1981) Thoracotomy in patients over age seventy years: ten-year experience. J Thorac Cardiovasc Surg 81:187–193

    CAS  PubMed  Google Scholar 

  70. Zapatero J, Madrigal L, Lago J et al (1990) Thoracic surgery in the elderly: review of 100 cases. Acta Chir Hung 31:227–234

    CAS  PubMed  Google Scholar 

  71. Allen MS, Darling GE, Pechet TT, ACOSOG Z0030 Study Group et al (2006) Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial. Ann Thorac Surg 81(3):1013–1019

    Article  PubMed  Google Scholar 

  72. Decamp MM Jr, Jaklitsch MT, Mentzer SJ et al (1995) The safety and versatility of video-thoracoscopy: a prospective analysis of 895 cases. J Am Coll Surg 181:113–120

    PubMed  Google Scholar 

  73. McKenna R (1994) Thoracoscopic lobectomy with mediastinal sampling in 80 year-old patients. Chest 106:1902–1904

    Article  PubMed  Google Scholar 

  74. Landreneau RL, Sugarbaker DJ, Mack MJ et al (1993) Postoperative pain-realted morbidity: video-assisted thoracic surgery versus thoracotomy. Ann Thorac Surg 56:1285–1289

    Article  CAS  PubMed  Google Scholar 

  75. Jaklitsch MT, Bueno R, Swanson SJ et al (1996) Video-assisted thoracic surgery in the elderly: a review of 307 cases. Chest 110:751–758

    Article  CAS  PubMed  Google Scholar 

  76. Cattaneo SM, Park BJ, Wilton AS et al (2008) Use of video-assisted thoracic surgery for lobectomy in the elderly results in fewer complications. Ann Thorac Surg 85:231–236

    Article  PubMed  Google Scholar 

  77. Ginsberg RJ, Rubinstein LV (1995) Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study Group. Ann Thorac Surg 60(3):615–622; discussion 622–623

    Article  CAS  PubMed  Google Scholar 

  78. Landreneau RJ, Sugarbaker DJ, Mack MJ et al (1997) Wedge resection versus lobectomy for stage I (T1 N0 M0) non-small-cell lung cancer. J Thorac Cardiovasc Surg 113(4):691–700

    Article  CAS  PubMed  Google Scholar 

  79. Kulke MH, Mayer RJ (1999) Carcinoid tumors. N Engl J Med 340(11):858–868

    Article  CAS  PubMed  Google Scholar 

  80. Marty-Ane C, Costes V, Pujol J et al (1995) Carcinoid tumors of the lung: do atypical features require aggressive management? Ann Thorac Surg 59(1):78–83

    Article  CAS  PubMed  Google Scholar 

  81. Mezzetti M, Raveglia F, Panigalli T et al (2003) Assessment of outcomes in typical and atypical carcinoids according to latest WHO classification. Ann Thorac Surg 76(6):1838–1842

    Article  PubMed  Google Scholar 

  82. Jaklitsch MT, Mery CM, Lukanich JM et al (2001) Sequential thoracic metastasectomy prolongs survival by re-establishing local control within the chest. J Thorac Cardiovasc Surg 121(4):657–667

    Article  CAS  PubMed  Google Scholar 

  83. Inoue M, Ohta M, Iuchi K et al (2004) Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma. Ann Thorac Surg 78(1):238–244

    Article  PubMed  Google Scholar 

  84. Weiser MR, Downey RJ, Leung DH, Brennan MF (2000) Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma. J Am Coll Surg 191(2):184–190; discussion 190–191

    Article  CAS  PubMed  Google Scholar 

  85. Saito Y, Omiya H, Kohno K et al (2002) Pulmonary metastasectomy for 165 patients with colorectal carcinoma: a prognostic assessment. J Thorac Cardiovasc Surg 124(5):1007–1013

    Article  PubMed  Google Scholar 

  86. Pfannschmidt J (2003) Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 126(3):732–739

    Article  PubMed  Google Scholar 

  87. Carballo M, Maish M, Jaroszewski D, Holmes C (2009) Video-assisted thoracic surgery (VATS) as a safe alternative for the resection of pulmonary metastases: a retrospective cohort study. J Cardiothorac Surg 4(1):13

    Article  PubMed  PubMed Central  Google Scholar 

  88. The International Registry of Lung Metastases, Writing Committee, Pastorino U et al (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg 113(1):37–49

    Article  Google Scholar 

  89. Collie DA, Wright AR, Williams JR et al (1994) Comparison of spiral-acquisition computed tomography and conventional computed tomography in the assessment of pulmonary metastatic disease. Br J Radiol 67(797):436–444

    Article  CAS  PubMed  Google Scholar 

  90. McCormack PM, Bains MS, Begg CB et al (1996) Role of video-assisted thoracic surgery in the treatment of pulmonary metastases: results of a prospective trial. Ann Thorac Surg 62(1):213–216

    Article  CAS  PubMed  Google Scholar 

  91. Reinhardt M, Wiethoelter N, Matthies A et al (2006) PET recognition of pulmonary metastases on PET/CT imaging: impact of attenuation-corrected and non-attenuation-corrected PET images. Eur J Nucl Med Mol Imaging 33(2):134–139

    Article  PubMed  Google Scholar 

  92. Nakajima J, Takamoto S, Tanaka M et al (2001) Thoracoscopic surgery and conventional open thoracotomy in metastatic lung cancer. Surg Endosc 15(8):849–853

    Article  CAS  PubMed  Google Scholar 

  93. Mutsaerts E, Zoetmulder F, Meijer S et al (2002) Long term survival of thoracoscopic metastasectomy vs metastasectomy by thoracotomy in patients with a solitary pulmonary lesion. Eur J Surg Oncol 28(8):864–868

    Article  CAS  PubMed  Google Scholar 

  94. Samet J, Hunt WC, Key C et al (1986) Choice of cancer therapy varies with age of patient. JAMA 255:3385–3390

    Article  CAS  PubMed  Google Scholar 

  95. Gridelli C, Langer C, Maione P et al (2007) Lung cancer in the elderly. J Clin Oncol 25(14):1989–1907

    Article  Google Scholar 

  96. McGarry RC, Song G, des Rosiers P et al (2002) Observation-only management of early stage, medically inoperable lung cancer: poor outcome. Chest 121:1155–1158

    Article  PubMed  Google Scholar 

  97. Yellin A, Brenfield JR (1985) Surgery for bronchogenic carcinoma in the elderly. Am Rev Respir Dis 131:197

    CAS  PubMed  Google Scholar 

  98. Arias E (2007) CDC. Natl Vital Stat Rep 56(9)

    Google Scholar 

  99. Goldstraw P et al (2016) The IASLC Lung Cancer Staging Project: proposals for revision of the TNM stage groupings in the forthcoming (eighth) edition of the TNM classification for lung cancer. J Thorac Oncol 11(1):39–51

    Article  PubMed  Google Scholar 

  100. National Center for Health Statistics (2017) Health, United States, 2016: with chartbook on long-term trends in health. National Center for Health Statistics, Hyattsville

    Google Scholar 

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Correspondence to Jeff Tarascio or Michael Jaklitsch .

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Fox, S., Bravo-Iñiguez, C., De Leon, L., Tarascio, J., Jaklitsch, M. (2019). Pulmonary Surgery for Malignant Disease in Older Adults. In: Rosenthal, R., Zenilman, M., Katlic, M. (eds) Principles and Practice of Geriatric Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-20317-1_40-1

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  • DOI: https://doi.org/10.1007/978-3-319-20317-1_40-1

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