Abstract
This chapter describes a decade of experience with lung cancer vaccine development at a single institution. Elements of review include rationale, developmental strategy, scientific approach relative to historical perspective, and clinical circumstance.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Tarver, T.: Cancer facts & figures 2012. American Cancer Society (ACS). J. Consum. Health Internet 16, 366–367 (2012)
Howlader, N., et al. (eds.): SEER cancer statistics review, 1975-2009 (Vintage 2009 populations), National Cancer Institute. Bethesda, MD. http://seer.cancer.gov/csr/1975_2009_pops09/, based on Nov 2011 SEER data submission, posted to the SEER web site, Apr 2012
van Meerbeeck, J.P., Fennell, D.A., De Ruysscher, D.K.: Small-cell lung cancer. Lancet 378, 1741–1755 (2011). doi:10.1016/S0140-6736(11)60165-7
Goldstraw, P., et al.: Non-small-cell lung cancer. Lancet 378, 1727–1740 (2011). doi:10.1016/S0140-6736(10)62101-0
Dalgleish, A.G.: Therapeutic cancer vaccines: why so few randomised phase III studies reflect the initial optimism of phase II studies. Vaccine 29, 8501–8505 (2011). doi:10.1016/j.vaccine.2011.09.012
Perez, C.A., Santos, E.S., Raez, L.E.: Active immunotherapy for non-small-cell lung cancer: moving toward a reality. Expert Rev. Anticancer Ther. 11, 1599–1605 (2011). doi:10.1586/era.11.155
Kantoff, P.W., et al.: Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411–422 (2010). doi:10.1056/NEJMoa1001294
Disis, M.L.: Immune regulation of cancer. J. Clin. Oncol. 28, 4531–4538 (2010). doi:10.1200/JCO.2009.27.2146
Shepherd, F.A., Douillard, J.Y., Blumenschein Jr., G.R.: Immunotherapy for non-small cell lung cancer: novel approaches to improve patient outcome. J. Thorac. Oncol. 6, 1763–1773 (2011). doi:10.1097/JTO.0b013e31822e28fc
Scott, A.M., Wolchok, J.D., Old, L.J.: Antibody therapy of cancer. Nat. Rev. Cancer 12, 278–287 (2012). doi:10.1038/nrc3236
Hirschowitz, E.A., Hiestand, D.M., Yannelli, J.R.: Vaccines for lung cancer. J. Thorac. Oncol. 1, 93–104 (2006)
Palucka, K., Banchereau, J.: Cancer immunotherapy via dendritic cells. Nat. Rev. Cancer 12, 265–277 (2012). doi:10.1038/nrc3258
Cranmer, L.D., Trevor, K.T., Hersh, E.M.: Clinical applications of dendritic cell vaccination in the treatment of cancer. Cancer Immunol. Immunother. CII 53, 275–306 (2004). doi:10.1007/s00262-003-0432-5
Keenan, B.P., Jaffee, E.M.: Whole cell vaccines – past progress and future strategies. Semin. Oncol. 39, 276–286 (2012). doi:10.1053/j.seminoncol.2012.02.007
Keilholz, U., et al.: Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J. Immunother. 25, 97–138 (2002)
Wolchok, J.D., et al.: Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin. Cancer Res. 15, 7412–7420 (2009). doi:10.1158/1078-0432.CCR-09-1624
Disis, M.L.: Immunologic biomarkers as correlates of clinical response to cancer immunotherapy. Cancer Immunol. Immunother. CII 60, 433–442 (2011). doi:10.1007/s00262-010-0960-8
Moodie, Z., et al.: Response definition criteria for ELISPOT assays revisited. Cancer Immunol. Immunother. CII 59, 1489–1501 (2010). doi:10.1007/s00262-010-0875-4
Hirschowitz, E.A., et al.: Autologous dendritic cell vaccines for non-small-cell lung cancer. J. Clin. Oncol. 22, 2808–2815 (2004). doi:10.1200/JCO.2004.01.074
Hirschowitz, E.A., Foody, T., Hidalgo, G.E., Yannelli, J.R.: Immunization of NSCLC patients with antigen-pulsed immature autologous dendritic cells. Lung Cancer 57, 365–372 (2007). doi:10.1016/j.lungcan.2007.04.002
Hirschowitz, E.A., et al.: Pilot study of 1650-G: a simplified cellular vaccine for lung cancer. J. Thorac. Oncol. 6, 169–173 (2011). doi:10.1097/JTO.0b013e3181fb5c22
Emens, L.A., Jaffee, E.M.: Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer Res. 65, 8059–8064 (2005). doi:10.1158/0008-5472.CAN-05-1797
Zitvogel, L., Apetoh, L., Ghiringhelli, F., Kroemer, G.: Immunological aspects of cancer chemotherapy. Nat. Rev. Immunol. 8, 59–73 (2008). doi:10.1038/nri2216
Garnett, C.T., Schlom, J., Hodge, J.W.: Combination of docetaxel and recombinant vaccine enhances T-cell responses and antitumor activity: effects of docetaxel on immune enhancement. Clin. Cancer Res. 14, 3536–3544 (2008). doi:10.1158/1078-0432.CCR-07-4025
Kodumudi, K.N., et al.: A novel chemoimmunomodulating property of docetaxel: suppression of myeloid-derived suppressor cells in tumor bearers. Clin. Cancer Res. 16, 4583–4594 (2010). doi:10.1158/1078-0432.CCR-10-0733
Kudrin, A., Hanna Jr., M.G.: Overview of the cancer vaccine field: are we moving forward? Hum. Vaccines Immunother. 8, 1135–1140 (2012)
Parmiani, G., et al.: Opposite immune functions of GM-CSF administered as vaccine adjuvant in cancer patients. Ann. Oncol. 18, 226–232 (2007). doi:10.1093/annonc/mdl158
Acknowledgements
Our program has been fortunate to have received support from our institution, our cancer center, philanthropists, and foundations and extramurally from state-supported initiatives and the National Institutes of Health.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Wien
About this chapter
Cite this chapter
Hirschowitz, E.A., Foody, T.H., Yannelli, J.R. (2013). Lung Cancer Immunotherapy: Programmatic Development, Progress, and Perspectives. In: Giese, M. (eds) Molecular Vaccines. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1419-3_23
Download citation
DOI: https://doi.org/10.1007/978-3-7091-1419-3_23
Published:
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-1418-6
Online ISBN: 978-3-7091-1419-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)