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Female Infertility and Fertility Preservation

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Clinical Reproductive Medicine and Surgery

Abstract

Infertility is a common problem, affecting 10–15 % of couples. This chapter focuses on evaluating the female for factors that can lead to infertility. As outcomes for cancer survivors improve and the population ages, many patients may be interested in fertility preservation for medical or social reasons. Treatment options for these patients are outlined. Indications for embryo, oocyte, and ovarian tissue cryopreservation are discussed.

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References

  1. Mosher WD, Pratt WF. Fecundity and infertility in the United States: incidence and trends. Fertil Steril. 1991;56:192.

    PubMed  CAS  Google Scholar 

  2. Greenhall E, Vessey M. The prevalence of subfertility: a review of the current confusion and a report of two new studies. Fertil Steril. 1990;54:978.

    PubMed  CAS  Google Scholar 

  3. Mosher W, Pratt W. Fecundity and infertility in the United States, 1965–1988. Advance Data from Vital and Health Statistics, No. 192, 4 Dec 1990. Hyattsville, MD: National Center for Health Statistics; 1990.

    Google Scholar 

  4. Maroulis GB. Effect of aging on fertility and pregnancy. Semin Reprod Endocrinol. 1991;9:165.

    Google Scholar 

  5. Treolar AE. Menarche, menopause and intervening fecundability. Hum Biol. 1974;46:89–107.

    Google Scholar 

  6. Henry L. Some data on natural fertility. Eugen Q. 1961;8:81.

    PubMed  CAS  Google Scholar 

  7. Stein ZA. A women’s age: childbearing and childrearing. Am J Epidemiol. 1985;121:327.

    PubMed  CAS  Google Scholar 

  8. Mosher AD. Infertility trends among US couples: 1965–1976. Fam Plann Perspect. 1982;14:22.

    PubMed  CAS  Google Scholar 

  9. Ventura SJ, Hamilton BE, Sutton PD. Revised birth and fertility rates for the United States, 2000 and 2001. Natl Vital Stat Rep. 2003;51:1.

    Google Scholar 

  10. Cramer DW, Walker AM, Schiff I. Statistical methods in evaluating the outcome of infertility therapy. Fertil Steril. 1979;32:80.

    PubMed  CAS  Google Scholar 

  11. Guttmacher AF. Factors effecting normal expectancy of conception. JAMA. 1956;161:855.

    CAS  Google Scholar 

  12. Centers for Disease Control and Prevention. 2009 Assisted reproductive technology success rates. National Summary and Fertility Clinic Reports. Atlanta, GA; 2011.

    Google Scholar 

  13. Myers JA. The natural history of tuberculosis in the human body. III. Tuberculous women and their children. Am Rev Respir Dis. 1961;84:558.

    PubMed  CAS  Google Scholar 

  14. Cates W, Rolfs RT, Aral SO. Sexually transmitted diseases, pelvic inflammatory disease, and infertility: an epidemiologic update. Epidemiol Rev. 1990;12:199–220.

    PubMed  Google Scholar 

  15. Wǿlner-Hanssen P, Kiviat NK, Holmes KK. Atypical pelvic inflammatory disease: subacute, chronic or subclinical upper genital tract infection in women. In: Holmes KK, Mardh P-A, Sparling PF, Weisner PJ, editors. Sexually transmitted disease. 2nd ed. New York: McGraw-Hill; 1990. p. 615–20.

    Google Scholar 

  16. Daly JW, Monif GRG. Salmonella typhi. In: Monif GRG, editor. Infectious diseases in obstetrics and gynecology. 2nd ed. Philadelphia: Harper & Row; 1986. p. 303.

    Google Scholar 

  17. Donnez J, Nisolle M, Smoes P, Gillet N, Beguin S, Casanas-Roux F. Peritoneal endometriosis and “endometriotic” nodules of the rectovaginal septum are two different entities. Fertil Steril. 1996;66:362–8.

    PubMed  CAS  Google Scholar 

  18. Vercellini P. Endometriosis: what a pain it is. Semin Reprod Endocrinol. 1997;15:251–61.

    PubMed  CAS  Google Scholar 

  19. Cunningham FG, Gant NF, Leveno KJ, Gilstrap LC, Hauth JC, Wenstrom KD, editors. Williams obstetrics. 22nd ed. New York: McGraw-Hill; 2005. p. 451–68.

    Google Scholar 

  20. Roth L, Taylor HS. Risks of smoking to reproductive health: assessment of women’s knowledge. Am J Obstet Gynecol. 2001;184:934–9.

    PubMed  CAS  Google Scholar 

  21. Stillman RJ, editor. Seminars in reproductive endocrinology: smoking and reproductive health. New York: Thieme; 1989.

    Google Scholar 

  22. Laurent SL, Thompson SJ, Addy C, Garrison CZ, Moore EE. An epidemiologic study of smoking and primary infertility in women. Fertil Steril. 1992;57:565–72.

    PubMed  CAS  Google Scholar 

  23. Kaye AD, Clarke AC, Sabar R, Vig S, Dhawan KP, Hofbauer R, et al. Herbal medications: current trends in anesthesiology practice-a hospital survey. J Clin Anesth. 2000;12:468–71.

    PubMed  CAS  Google Scholar 

  24. Williams M, Hill CJ, Scudamore I, Dunphy B, Cooke ID, Barratt CLR. Sperm numbers and distribution within the human fallopian tube around ovulation. Hum Reprod. 1993;8:2019.

    PubMed  CAS  Google Scholar 

  25. Gould JE, Overstreet JW, Hanson FW. Assessment of human sperm function after recovery from the female reproductive tract. Biol Reprod. 1984;31:888.

    PubMed  CAS  Google Scholar 

  26. Glatt AE, Zinner SH, McCormack WM. The prevalence of dyspareunia. Obstet Gynecol. 1990;75:433.

    PubMed  CAS  Google Scholar 

  27. Adamson GD. Diagnosis and clinical presentation of endometriosis. Am J Obstet Gynecol. 1990;162:568.

    PubMed  CAS  Google Scholar 

  28. Brosens IA, Brosens JJ. Redefining endometriosis: is deep endometriosis a progressive disease? Hum Reprod. 2000;15:1.

    PubMed  CAS  Google Scholar 

  29. Nishida M. Relationship between the onset of dysmenorrhea and histologic findings in adenomyosis. Am J Obstet Gynecol. 1991;165:229.

    PubMed  CAS  Google Scholar 

  30. Reinhold C, Atri M, Mehio A, Zakarian R, Aldis AE, Bret PM, et al. Diffuse uterine adenomyosis: morphologic criteria and diagnostic accuracy of endovaginal sonograph. Radiology. 1995;197:609.

    PubMed  CAS  Google Scholar 

  31. Garcia-Velasco JA, Arici A. Chemokiines and human reproduction. Fertil Steril. 1999;71:983.

    PubMed  CAS  Google Scholar 

  32. Chandra A, Mosher WD, Copen C, Sionean C. Sexual behavior, sexual attraction, and sexual identity in the United States: data from the 2006–2008 National Survey of Family Growth. Natl Health Stat Report. 2011;36:1–36.

    PubMed  Google Scholar 

  33. Diamant AL, Schuster MA, McGuigan K, Lever J. Lesbians’ sexual history with men: implications for taking a sexual history. Arch Intern Med. 1999;159:2730–6.

    PubMed  CAS  Google Scholar 

  34. Marrazzo JM, Stine K. Reproductive health history of lesbians: implications for care. Am J Obstet Gynecol. 2004;190:1298–304.

    PubMed  Google Scholar 

  35. Banna M. Craniopharyngioma: based on 160 cases. Br J Radiol. 1976;49:206.

    PubMed  CAS  Google Scholar 

  36. Sklar CA. Craniopharyngioma: endocrine abnormalities at presentation. Pediatr Neurosurg. 1994;21:18.

    PubMed  Google Scholar 

  37. Schlechte J, Sherman B, Halmi N, Van Gilder J, Chapler FK, Dolan K, et al. Prolactin-secreting pituitary tumors. Endocr Rev. 1980;1:295.

    PubMed  CAS  Google Scholar 

  38. Vallette-Kasic S, Morange-Ramus I, Selim A, Gunz G, Morange S, Enjalbert A, et al. Macroprolactinemia revisited: a study on 106 patients. J Clin Endocrinol Metab. 2002;87:581.

    PubMed  CAS  Google Scholar 

  39. Smith G, Roberts R, Hall C, Nuki G. Reversible ovulatory failure associated with the development of luteinized unruptured follicles in women with inflammatory arthritis taking non-steroidal anti-inflammatory drugs. Br J Rheumatol. 1996;35:458–62.

    PubMed  CAS  Google Scholar 

  40. Zanagnolo V, Dharmarajan AM, Endo K, Wallach EE. Effects of acetylsalicylic acid (aspirin) and naproxen sodium (naproxen) on ovulation, prostaglandin, and progesterone production in the rabbit. Fertil Steril. 1996;65:1036–43.

    PubMed  CAS  Google Scholar 

  41. Freda PU, Wardlaw SL, Post KD. Unusual causes of sellar/parasellar masses in a large transsphenoidal surgical series. J Clin Endocrinol Metab. 1996;81:3455.

    PubMed  CAS  Google Scholar 

  42. Hurley D, Gharib H. Detection and treatment of hypothyroidism and Grave’s disease. Geriatrics. 1995;60:41.

    Google Scholar 

  43. Krassas GE, Pontikides N, Kaltsas T, Papadopoulou P, Batrinos M. Menstrual disturbances in thyrotoxicosis. Clin Endocrinol (Oxf). 1994;40:641.

    CAS  Google Scholar 

  44. Frisch RE. The right weight: body fat, menarche and ovulation. Baillieres Clin Obstet Gynecol. 1990;4:419–39.

    CAS  Google Scholar 

  45. Drukker BH. Examination of the breast by the patient and by the physician. In: Hindle W, editor. Breast disease for gynecologists. New York: Appleton & Lange; 1990. p. 52–4.

    Google Scholar 

  46. Miller JW, Crapo L. The medical treatment of Cushing’s disease. Endocr Rev. 1993;14:443.

    PubMed  CAS  Google Scholar 

  47. Herbst AL, Bern HA, editors. Developmental effects of diethylstilbesterol(DES) in pregnancy. New York: Thieme-Stratton; 1981.

    Google Scholar 

  48. The Practice Committee of the American Society for Reproductive Medicine. Vaccinations guidelines for female infertility patients. Fertil Steril. 2008;90(3):S169–71.

    Google Scholar 

  49. The Practice Committee of the American Society for Reproductive Medicine. Guidelines for reducing the risk of viral transmission during fertility treatment. Fertil Steril. 2008;90(3):S156–62.

    Google Scholar 

  50. Fleischer AC. Sonography in gynecology & obstetrics: just the facts. New York: McGraw-Hill; 2004.

    Google Scholar 

  51. Timor-Tritsch IE, Rottem S, editors. Transvaginal sonography. 2nd ed. New York: Elsevier; 1991.

    Google Scholar 

  52. Hurd WW, Wyckoff ET, Reynolds DB, Amesse LS, Gruber JS, Horowitz GA. Patient rotation and resolution of unilateral cornual obstruction during hysterosalpingography. Obstet Gynecol. 2003;101:1275.

    PubMed  Google Scholar 

  53. Spring DB, Barkan HE, Pruyn SC. Potential therapeutic effects of contrast materials in hysterosalpingography: a prospective randomized clinical trial. Kaiser Permanente Infertility Work Group. Radiology. 2000;214:53–7.

    PubMed  CAS  Google Scholar 

  54. Glatstein IZ, Best CL, Palumbo A, Sleeper LA, Friedman AJ, Hornstein MD. The reproducibility of the postcoital test: a prospective study. Obstet Gynecol. 1995;85(3):396–400.

    PubMed  CAS  Google Scholar 

  55. Beltsos AN, Fisher S, Uhler ML, Clegg ED, Zinaman M. The relationship of the postcoital test and semen characteristics to pregnancy rates in 200 presumed fertile couples. Int J Fertil Menopausal Stud. 1996;41(4):405–11.

    PubMed  CAS  Google Scholar 

  56. Hurd WW, Randolph JF, Ansbacher R, Menge AC, Ohl DA, Brown AN. Comparison of intracervical, intrauterine, and intratubal techniques for donor insemination. Fertil Steril. 1993;59:339–42.

    PubMed  CAS  Google Scholar 

  57. Luciano AA, Peluso J, Koch EI, Maier D, Kuslis S, Davison E. Temporal relationship and reliability of the clinical, hormonal and Ultrasonographic indices of ovulation in infertile women. Obstet Gynecol. 1990;75:412.

    PubMed  CAS  Google Scholar 

  58. Bates GW, Garza DE, Garza MM. Clinical manifestations of hormonal changes in the menstrual cycle. Obstet Gynecol Clin North Am. 1990;17:299.

    PubMed  CAS  Google Scholar 

  59. Moghissi KS. Accuracy of basal body temperature for ovulation induction. Fertil Steril. 1976;27:1415–21.

    PubMed  CAS  Google Scholar 

  60. Moghissi KS. Prediction and detection of ovulation. Fertil Steril. 1980;34:89–98.

    PubMed  CAS  Google Scholar 

  61. Investigators World Health Organization Task Force. Temporal relationships between ovulation and defined changes in the concentration of plasma estradiol-17β, luteinizing hormone, follicle stimulating hormone and progesterone. Am J Obstet Gynecol. 1980;138:383–90.

    Google Scholar 

  62. Wathen NC, Perry L, Lilford RJ, Chard T. Interpretation of single progesterone measurement in diagnosis of anovulation and defective luteal phase: observations on analysis of the normal; range. Br Med J. 1984;288:7.

    CAS  Google Scholar 

  63. Jordan J, Craig K, Clifton DK, Soules MR. Luteal phase defect: the sensitivity and specificity of diagnostic methods in common clinical use. Fertil Steril. 1994;62:55–62.

    Google Scholar 

  64. Filicori M, Butler JP, Crowley WF. Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion. J Clin Invest. 1984;73:1638–47.

    PubMed  CAS  Google Scholar 

  65. Noyes RW, Hertig AT, Rock J. Dating the endometrium. Fertil Steril. 1950;1:3–25.

    Google Scholar 

  66. Miller PR, Soules MR. The usefulness of a urinary LH kit for ovulation prediction during cycles of normal women. Obstet Gynecol. 1996;87:13.

    PubMed  CAS  Google Scholar 

  67. Lang-Dunlop A, Schultz R, Frank E. Interpretation of the BBT chart using the “Gap” technique compared to the colorline technique. Contraception. 2005;71:188–92.

    PubMed  Google Scholar 

  68. Martinez AR, Bernardus RE, Vermeiden JP, Schoemaker J. Time schedules of intrauterine insemination after urinary luteinizing hormone surge detection and pregnancy results. Gynecol Endocrinol. 1994;8:1.

    PubMed  CAS  Google Scholar 

  69. Nielsen MS, Barton SD, Hatasaka HH, Stanford JB. Comparison of several one-step home urinary hormone detection kits to OvuQuick. Fertil Steril. 2001;76:384.

    PubMed  CAS  Google Scholar 

  70. Lloyd R, Coulam CB. The accuracy of urinary luteinizing hormone testing in predicting ovulation. Am J Obstet Gynecol. 1989;160:1370–2.

    PubMed  CAS  Google Scholar 

  71. Coutifaris C, Myers ER, Guzick DS, Diamond MP, Carson SA, Legro RS, et al. Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril. 2004;82(5):1264–72.

    PubMed  Google Scholar 

  72. Spencer C, Eigen A, Shen D, Duda M, Qualls S, Weiss S, et al. Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients. Clin Chem. 1987;33:1391–6.

    PubMed  CAS  Google Scholar 

  73. Bohnet HG, Dahlen HG, Wutke W, Schneider HPG. Hyper-prolactinemic anovulatory syndrome. J Clin Endocrinol Metab. 1976;42:132.

    PubMed  CAS  Google Scholar 

  74. Moult PJA, Rees LH, Besser GM. Pulsatile gonadotropin secretion in hyperprolactinemic amenorrhoea and the response to bromocriptine therapy. Clin Endocrinol. 1982;16:153.

    CAS  Google Scholar 

  75. Yen SSC, Jaffe RB. Prolactin in human reproduction. In: Yen SSC, Jaffe RB, Barbieri RL, editors. Reproductive endocrinology: physiology, pathophysiology and clinical management. 4th ed. Philadelphia: WB Saunders; 1999. p. 273–4.

    Google Scholar 

  76. Hatjis CG, Morris M, Rose JC, Kofinas AD, Penry M, Swain M. Oxytocin, vasopressin and prolactin responses associated with nipple stimulation. South Med J. 1989;82:193–6.

    PubMed  CAS  Google Scholar 

  77. Hammond KR, Steinkampf MP, Boots LR, Blackwell RE. The effect of routine breast examination on serum prolactin levels. Fertil Steril. 1996;65(4):869–70.

    PubMed  CAS  Google Scholar 

  78. Jacobs LS, Snyder PJ, Wilbur JF, Utiger RD, Daughaday WH. Increased serum prolactin after administration of synthetic ­thyrotropin releasing hormone (TRH) in man. J Clin Endocrinol Metab. 1971;33:966.

    Google Scholar 

  79. Scott RT, Toner JP, Muasher SJ, Oehninger S, Robinson S, Rosenwaks Z. Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril. 1989;51:651.

    PubMed  CAS  Google Scholar 

  80. Toner JP, Philput CB, Jones GS, Muasher SJ. Basal follicle-­stimulating hormone is a better predictor of in vitro fertilization performance than age. Fertil Steril. 1991;55:784.

    PubMed  CAS  Google Scholar 

  81. Pearlstone AC, Fournet N, Gambone JC, Pang SC, Buyalos RP. Ovulation induction in women over 40 and older: the importance of basal follicle-stimulating hormone level and chronological age. Fertil Steril. 1992;58:674.

    PubMed  CAS  Google Scholar 

  82. Evers JL, Slaats P, Land JA, Dumoulin JC, Dunselman GA. Elevated levels of basal estradiol-17 beta predict poor response in patients with normal basal levels of follicle stimulating hormone undergoing in vitro fertilization. Fertil Steril. 1998;69:1010–4.

    PubMed  CAS  Google Scholar 

  83. Broekmans FJ, Kwee J, Hendriks DJ, Mol BW, Lambalk CB. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update. 2006;12:685–718.

    PubMed  CAS  Google Scholar 

  84. Scott RT, Hofmann GE. Prognostic assessment of ovarian reserve. Fertil Steril. 1995;63:1.

    PubMed  Google Scholar 

  85. Navot D, Rosenwaks Z, Margolioth EJ. Prognostic assessment of female fecundity. Lancet. 1987;2:645.

    PubMed  CAS  Google Scholar 

  86. Hendriks DJ, Mol BW, Bancsi LF, Te Valde ER, Broekmans FJ. Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal follicle stimulating hormone level. Fertil Steril. 2005;83:291–301.

    PubMed  Google Scholar 

  87. Tsepelidis S, Devreker F, Demeestere I, Flahuat A, Gervy C, Englert Y. Stable serum levels of anti-Mullerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum Reprod. 2007;22:1837–40.

    PubMed  CAS  Google Scholar 

  88. Marca L. Stabile G, Artensio AC, Volpe A. Serum anti-Mullerian hormone throughout the menstrual cycle. Hum Reprod. 2006;21:3103–7.

    PubMed  Google Scholar 

  89. Muttukrishna S, McGarrigle H, Wakim R, Khadum I, Ranieri DM, Serhal P. Antral follicle count, anti-Mullerian hormone and inhibin B: predictors of ovarian response in assisted reproductive technology? BJOG. 2005;112:1384–90.

    PubMed  CAS  Google Scholar 

  90. Ebner T, Sommergruber M, Moser M, Shebl O, Schreier-Lechner E, Tews G. Basal levels of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod. 2006;21:2022–6.

    PubMed  CAS  Google Scholar 

  91. Surveillance Epidemiology and End Results Cancer Statistics. http://seer.cancer.gov Accessed 20 Aug 2012.

  92. You W, Dainty LA, Rose GS, Krivak T, McHale MT, Olsen CH, et al. Gynecologic malignancies in women aged less than 25 years. Obstet Gynecol. 2005;105(6):1405–9.

    PubMed  Google Scholar 

  93. Schilsky RL, Sherins RJ, Hubbard SM, Wesley MN, Young RC, DeVita VT, et al. Long-term follow up of ovarian function in women treated with MOPP chemotherapy for Hodgkin’s disease. Am J Med. 1981;71:552–6.

    PubMed  CAS  Google Scholar 

  94. Multidisciplinary Working Group convened by the BFS. A strategy for fertility services for survivors of childhood cancer. Hum Fertil. 2003;6:A1–40.

    Google Scholar 

  95. Bath LE, Tydeman G, Critchley HO, Anderson RA, Baird DT, Wallace WH. Spontaneous conception in a young woman who had ovarian cortical tissue cryopreserved before chemotherapy and radiotherapy for a Ewing’s sarcoma of the pelvis: case report. Hum Reprod. 2004;19:2569–72.

    PubMed  CAS  Google Scholar 

  96. Bath LE, Wallace WH, Shaw MP, Fitzpatrick C, Anderson RA. Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-Mullerian hormone, inhibin B and ovarian ultrasound. Hum Reprod. 2003;18:2569–72.

    Google Scholar 

  97. Crofton PM, Thomson AB, Evans AE, Groome NP, Bath LE, Kelnar CJ, et al. Is inhibin B a potential marker of gonadotoxicity in prepubertal children treated for cancer? Clin Endocrinol (Oxf). 2003;58:296–301.

    CAS  Google Scholar 

  98. Lushbaugh C, Casarett GW. The effects of gonadal irradiation in clinical radiation therapy: a review. Cancer. 1976;37 Suppl 2Suppl 2:1111–25.

    PubMed  CAS  Google Scholar 

  99. Perez CA, Purdy JA, Li Z, Hall EJ. Biologic and physical aspects of radiation oncology. In: Hoskins WJ, Perez CA, Young RC, Barakat R, Markman M, Randall ME, editors. Principles and practice of gynecologic oncology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 446–7.

    Google Scholar 

  100. Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys. 2005;62(3):738–44.

    PubMed  Google Scholar 

  101. Morice P, Juncker L, Rey A, El-Hassan J, Haie-Meder C, Castaigne D. Ovarian transposition for patients with cervical carcinoma treated by radiosurgical combination. Fertil Steril. 2000;74:743–8.

    PubMed  CAS  Google Scholar 

  102. Gaetini A, De Simone M, Urgesi A, Levis A, Resegotti A, Ragona R, et al. Lateral high abdominal ovariopexy: an original surgical technique for protection of the ovaries during curative radiotherapy for Hodgkin’s disease. J Surg Oncol. 1988;39:22–8.

    PubMed  CAS  Google Scholar 

  103. Williams RS, Littell RD, Mendenhall NP. Laparoscopic oophoropexy and ovarian function in the treatment of Hodgkin disease. Cancer. 1999;86:2138–42.

    PubMed  CAS  Google Scholar 

  104. Meirow D, Schenker JG, Rosler A. Ovarian hyperstimulation syndrome with low oestradiol in non-classical 17 alpha-hydroxylase, 17,20-lyase deficiency: what is the role of oestrogens? Hum Reprod. 1996;11:2119–21.

    PubMed  CAS  Google Scholar 

  105. Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. GermLine stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004;428:145–50.

    PubMed  CAS  Google Scholar 

  106. Critchley HO, Wallace WH. Impact of cancer treatment on uterine function. J Natl Cancer Inst Monogr. 2005;34:64–8.

    PubMed  Google Scholar 

  107. Anchan RM, Ginsburg ES. Fertility concerns and preservation in younger women with breast cancer. Crit Rev Oncol Hematol. 2010;74:175–92.

    PubMed  Google Scholar 

  108. Bath LE, Wallace WH, Critchley HO. Late effects of the treatment of childhood cancer on the female reproductive system and the potential for fertility preservation. BJOG. 2002;109:107–14.

    PubMed  Google Scholar 

  109. Hawkins MM, Smith RA. Pregnancy outcomes in childhood cancer survivors: probable effects of abdominal irradiation. Int J Cancer. 1989;43:399–402.

    PubMed  CAS  Google Scholar 

  110. Noyes N, Knopman J, Long K, Coletta JM, Abu-Rustum NR. Fertility considerations in the management of gynecologic malignancies. Gynecol Oncol. 2011;120:326–33.

    PubMed  Google Scholar 

  111. Plante M, Renaud MC, Francois H, Roy M. Vaginal radical trachelectomy: an oncologically safe fertility-preserving surgery. An updated series of 72 cases and a review of the literature. Gynecol Oncol. 2004;94:614–23.

    PubMed  Google Scholar 

  112. Plante M. Fertility preservation in the management of cervical cancer. CME J Gynecol Oncol. 2003;8:97–107.

    Google Scholar 

  113. Howard FM. Laparoscopic lateral ovarian transposition before radiation treatment of Hodgkin disease. J Am Assoc Gynecol Laparosc. 1997;4:601–4.

    PubMed  CAS  Google Scholar 

  114. Treissman MJ, Miller D, McComb PF. Laparoscopic lateral ovarian transposition. Fertil Steril. 1996;65:1229–31.

    PubMed  CAS  Google Scholar 

  115. Yarali H, Demirol A, Bukulmez O, Coskun F, Gürgan T. Laparoscopic high lateral transposition of both ovaries before pelvic irradiation. J Am Assoc Gynecol Laparosc. 2000;7:237–9.

    PubMed  CAS  Google Scholar 

  116. Bidzinski M, Lemieszczuk B, Zielinski J. Evaluation of the hormonal function and features of the ultrasound picture of transposed ovary in cervical cancer patients after surgery and pelvic irradiation. Eur J Gynaecol Oncol. 1993;14:77–80.

    PubMed  Google Scholar 

  117. Morice P, Castaigne D, Haie-Meder C, Pautier P, El Hassan J, Duvillard P, et al. Laparoscopic ovarian transposition for pelvic malignancies: indications and functional outcomes. Fertil Steril. 1998;70:956–60.

    PubMed  CAS  Google Scholar 

  118. Feeney DD, Moore DH, Look KY, Stehman FB, Sutton GP. The fate of the ovaries after radical hysterectomy and ovarian transposition. Gynecol Oncol. 1995;56:3–7.

    PubMed  CAS  Google Scholar 

  119. Chiarelli AM, Marrett LD, Darlington G. Early menopause and infertility in females after treatment for childhood cancer diagnosed in 1964-1988 in Ontario, Canada. Am J Epidemiol. 1999;150:245–54.

    PubMed  CAS  Google Scholar 

  120. Tangir J, Zelterman D, Ma W, Schwartz PE. Reproductive function after conservative surgery and chemotherapy for malignant germ cell tumors of the ovary. Obstet Gynecol. 2003;101:251–7.

    PubMed  Google Scholar 

  121. Blumenfeld Z. Ovarian cryopreservation versus ovarian suppression by GnRH analogues: primum non nocere. Hum Reprod. 2004;19:1924–5.

    PubMed  CAS  Google Scholar 

  122. Ataya K, Rao LV, Lawrence E, Kimmel R. Luteinizing hormone-releasing hormone agonist inhibits cyclophosphamide- induced ovarian follicular depletion in rhesus monkeys. Biol Reprod. 1995;52:365–72.

    PubMed  CAS  Google Scholar 

  123. Blumenfeld Z, Dann E, Avivi I, Epelbaum R, Rowe JM. Fertility after treatment for Hodgkin’s disease. Ann Oncol. 2002;13:138–47.

    PubMed  Google Scholar 

  124. Pereyra Pacheco B, Mendez Ribas JM, Milone G, Fernández I, Kvicala R, Mila T, et al. Use of GnRH analogs for functional protection of the ovary and preservation of fertility during cancer treatment in adolescents: a preliminary report. Gynecol Oncol. 2001;81:391–7.

    PubMed  CAS  Google Scholar 

  125. Fox KR, Mik R, Moore HC. Prevention of chemotherapy-associated amenorrhea (CRA) with leuprolide in young women with early stage breast cancer (Abstract). Proc Ann Soc Clin Oncol. 2001;25a.

    Google Scholar 

  126. Somers EC, Marder W, Christman GM, Ognenovski V, McCune WJ. Use of gonadotropin-releasing hormone analog for protection against premature ovarian failure during cyclophosphamide therapy in women with severe lupus. Arthritis Rheum. 2005;52:2761–7.

    PubMed  CAS  Google Scholar 

  127. Blumenfeld Z, Avivi I, Eckam A, Epelbaum R, Rowe JM, Dann EJ. Gonadotropin-releasing hormone agonist decreases chemotherapy-induced gonadotoxicity and premature ovarian failure in young female patients with Hodgkin lymphoma. Fertil Steril. 2008;1:166–73.

    Google Scholar 

  128. Del Mastro L, Boni L, Michelotti A, Gamucci T, Olmeo N, Gori S, et al. Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. JAMA. 2011;306(3):269–76.

    PubMed  Google Scholar 

  129. Munster PN, Moore AP, Ismail-Kahn R, Cox CE, Lacevic M, Gross-King M, et al. Randomized trial using gonadotropin-­releasing hormone agonist triptorelin for preservation of ovarian function during neoadjuvant chemotherapy for breast cancer. J Clin Oncol. 2012;30(5):533–8.

    PubMed  CAS  Google Scholar 

  130. Practice Committees of the American Society for Reproductive Medicine. Mature oocytes cryopreservation: a guideline. Fertil Steril. 2012;99(1):37–43.

    Google Scholar 

  131. Society for Assisted Reproductive Technology. http://www.sart.org. Accessed: 20 Aug 2012.

  132. Kolibianakis EM, Venetis CA, Tarlatzis BC. Cryopreservation of human embryos by vitrification or slow-freeze: which one is better? Curr Opin Obstet Gynecol. 2009;21:270–4.

    PubMed  Google Scholar 

  133. Pelinck MJ, Hoek A, Simons AH, Heineman MJ. Efficacy of natural cycle IVF: a review of the literature. Hum Reprod Update. 2002;8:129–39.

    PubMed  CAS  Google Scholar 

  134. Oktay K, Buyuk E, Davis O, Yermakova I, Veeck L, Rosenwaks Z. Fertility preservation in breast cancer patients: IVF and embryo cryopreservation after ovarian stimulation with tamoxifen. Hum Reprod. 2003;18:90–5.

    PubMed  CAS  Google Scholar 

  135. Noyes N, Knopman J, Metser K, Friedman B, Fino ME, Westphal LM. Oocyte cryopreservation as a fertility measure for cancer patients. Reprod Biomed Online. 2011;23:323–33.

    PubMed  CAS  Google Scholar 

  136. von Wolff M, Thaler CJ, Frambach T, Zeeb C, Lawrenz B, Popovici RM, et al. Ovarian stimulation to cryopreserve fertilized oocytes in cancer patients can be started in the luteal phase. Fertil Steril. 2009;92(4):1360–5.

    Google Scholar 

  137. Oktay K, Buyuk E, Libertella N, Akar M, Rosenwaks Z. Fertility preservation in breast cancer patients: prospective controlled comparison of ovarian stimulation with Tamoxifen and Letrozole for embryo cryopreservation. J Clin Oncol. 2005;23(19):4347–53.

    PubMed  CAS  Google Scholar 

  138. Azim AA, Costantini-Ferrando M, Oktay K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective study. J Clin Oncol. 2008;26:2630–5.

    PubMed  CAS  Google Scholar 

  139. Oktay K, Kan MT, Rosenwaks Z. Recent progress in oocyte and ovarian tissue cryopreservation and transplantation. Curr Opin Obstet Gynecol. 2001;13:263–8.

    PubMed  CAS  Google Scholar 

  140. Magistrini M, Szollosi D. Effects of cold and of isopropyl-N-phenylcarbamate on the second meiotic spindle of mouse oocytes. Eur J Cell Biol. 1980;22:699–707.

    PubMed  CAS  Google Scholar 

  141. Stachecki JJ, Cohen J, Willadsen S. Detrimental effects of sodium during mouse oocyte cryopreservation. Biol Reprod. 1998;59:395–400.

    PubMed  CAS  Google Scholar 

  142. Shaw JM, Jones GM. Terminology associated with vitrification and other cryopreservation procedures for oocytes and embryos. Hum Reprod Update. 2003;9:583–605.

    PubMed  CAS  Google Scholar 

  143. Smith GD, Serafini PC, Fioravanti J, Yadid I, Coslovsky M, Hassun P, et al. Prospective randomized comparison of human oocyte cryopreservation with slow rate freezing or vitrification. Fertil Steril. 2010;94:2088–95.

    PubMed  Google Scholar 

  144. Noyes N, Porcu E, Borini A. With more than 900 babies born, live birth outcomes following oocyte cryopreservation do not appear different from those occurring after conventional IVF. Reprod Biomed Online. 2009;18:769–76.

    PubMed  CAS  Google Scholar 

  145. Oktay K, Buyuk E. The potential of ovarian tissue transplant to preserve fertility. Expert Opin Biol Ther. 2002;2:361–70.

    PubMed  Google Scholar 

  146. Baird DT, Webb R, Campbell BK, Harkness LM, Gosden RG. Long-term ovarian function in sheep after ovariectomy and transplantation of autografts stored at -196 C. Endocrinology. 1999;140:462–71.

    PubMed  CAS  Google Scholar 

  147. Oktay K, Nugent D, Newton H, Salha O, Chatterjee P, Gosden RG. Isolation and characterization of primordial follicles from fresh and cryopreserved human ovarian tissue. Fertil Steril. 1997;67:481–6.

    PubMed  CAS  Google Scholar 

  148. Aubard Y. Ovarian tissue graft: from animal experiment to practice in the human. Eur J Obstet Gynecol Reprod Biol. 1999;86:1–3.

    PubMed  CAS  Google Scholar 

  149. Lomax CW, Harbert GM, Thornton WN. Actinomycosis of the female genital tract. Obstet Gynecol. 1976;48:341.

    PubMed  CAS  Google Scholar 

  150. Oktay K, Buyuk E, Veeck L, Zaninovic N, Xu K, Takeuchi T, et al. Embryo development after heterotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;363:837–40.

    PubMed  Google Scholar 

  151. Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–10.

    PubMed  CAS  Google Scholar 

  152. Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318–21.

    PubMed  CAS  Google Scholar 

  153. Smitz JE, Thompson JG, Gilchrist RB. The promise of in vitro maturation in assisted reproduction and fertility preservation. Semin Reprod Med. 2011;29(1):24–37.

    PubMed  CAS  Google Scholar 

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Correspondence to Lynn M. Westphal MD .

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Perfetto, C.O. et al. (2013). Female Infertility and Fertility Preservation. In: Falcone, T., Hurd, W. (eds) Clinical Reproductive Medicine and Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6837-0_12

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