Most Cited Articles of Clinical endpoint

New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)European Journal of Cancer200916.1K
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaNew England Journal of Medicine200513.7K
New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of CanadaJournal of the National Cancer Institute200013.6K
Improved survival with ipilimumab in patients with metastatic melanomaNew England Journal of Medicine201010.6K
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2New England Journal of Medicine20018.7K
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerNew England Journal of Medicine20128.7K
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerNew England Journal of Medicine20048.5K
Gene expression profiling predicts clinical outcome of breast cancerNature20027.4K
Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patientsNew England Journal of Medicine20006.9K
Reporting results of cancer treatmentCancer19816.7K
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study InvestigatorsNew England Journal of Medicine19996.6K
Rivaroxaban versus warfarin in nonvalvular atrial fibrillationNew England Journal of Medicine20116.3K
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinomaNew England Journal of Medicine20096.3K
Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study GroupNew England Journal of Medicine19956.3K
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigatorsNew England Journal of Medicine19966.1K
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrestNew England Journal of Medicine20026K
Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung CancerNew England Journal of Medicine20156K
Reduced lung-cancer mortality with low-dose computed tomographic screeningNew England Journal of Medicine20115.8K
Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancerScience19895.8K
Safety and Efficacy of the BNT162b2 mRNA Covid-19 VaccineNew England Journal of Medicine20205.6K
Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational studyLancet Respiratory Medicine,the20205.6K
Short screening scales to monitor population prevalences and trends in non-specific psychological distressPsychological Medicine20025.6K
Nivolumab versus Docetaxel in Advanced Squamous-Cell Non-Small-Cell Lung CancerNew England Journal of Medicine20155.5K
Safety and activity of anti-PD-L1 antibody in patients with advanced cancerNew England Journal of Medicine20125.5K
Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyNew England Journal of Medicine20015.5K