Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes | Journal of Molecular Biology | 2001 | 8.8K |
Ghrelin is a growth-hormone-releasing acylated peptide from stomach | Nature | 1999 | 6.8K |
Targeting HIF-1 for cancer therapy | Nature Reviews Cancer | 2003 | 5.3K |
Crystal structure of rhodopsin: A G protein-coupled receptor | Science | 2000 | 5K |
Molecular characterization of a peripheral receptor for cannabinoids | Nature | 1993 | 3.9K |
Getting to the site of inflammation: the leukocyte adhesion cascade updated | Nature Reviews Immunology | 2007 | 2.9K |
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor | Science | 2007 | 2.8K |
Calcium signaling | Cell | 2007 | 2.8K |
Pharmacology and functions of metabotropic glutamate receptors | Annual Review of Pharmacology and Toxicology | 1997 | 2.6K |
ERBB receptors and cancer: the complexity of targeted inhibitors | Nature Reviews Cancer | 2005 | 2.6K |
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism | Nature Reviews Genetics | 2006 | 2.4K |
Monocyte chemoattractant protein-1 (MCP-1): an overview | Journal of Interferon and Cytokine Research | 2009 | 2.2K |
Crystal structure of the β2 adrenergic receptor-Gs protein complex | Nature | 2011 | 2.2K |
The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints | Molecular Pharmacology | 2003 | 2.1K |
Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators | Nature Reviews Immunology | 2008 | 2.1K |
TRP channels as cellular sensors | Nature | 2003 | 2.1K |
Seven-transmembrane receptors | Nature Reviews Molecular Cell Biology | 2002 | 2K |
Targeting the phosphoinositide 3-kinase pathway in cancer | Nature Reviews Drug Discovery | 2009 | 1.9K |
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor | Nature | 1998 | 1.8K |
Sphingosine-1-phosphate: an enigmatic signalling lipid | Nature Reviews Molecular Cell Biology | 2003 | 1.8K |
A transmembrane intracellular estrogen receptor mediates rapid cell signaling | Science | 2005 | 1.8K |
The influence of drug-like concepts on decision-making in medicinal chemistry | Nature Reviews Drug Discovery | 2007 | 1.7K |
Protein kinases--the major drug targets of the twenty-first century? | Nature Reviews Drug Discovery | 2002 | 1.7K |
Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression | Journal of Immunology | 2006 | 1.7K |
GSK-3: tricks of the trade for a multi-tasking kinase | Journal of Cell Science | 2003 | 1.7K |