Most Cited Articles of Downregulation and upregulation

Atherosclerosis--an inflammatory diseaseNew England Journal of Medicine199917.3K
Epithelial-mesenchymal transitions in development and diseaseCell20097.3K
Immunity, inflammation, and cancerCell20106.8K
The ubiquitin systemAnnual Review of Biochemistry19986.8K
Reactive oxygen species and antioxidant machinery in abiotic stress tolerance in crop plantsPlant Physiology and Biochemistry20106.1K
Oncomirs - microRNAs with a role in cancerNature Reviews Cancer20065.9K
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistanceScience19935.8K
Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsNature Immunology20035.8K
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCRNucleic Acids Research20025.5K
The NF-kappa B and I kappa B proteins: new discoveries and insightsAnnual Review of Immunology19965.3K
Immunobiology of dendritic cellsAnnual Review of Immunology20005.3K
Epithelial-mesenchymal transitions in tumour progressionNature Reviews Cancer20025.2K
New functions for the matrix metalloproteinases in cancer progressionNature Reviews Cancer20024.8K
U1 snRNP regulates cancer cell migration and invasion in vitroNature Communications20204.7K
Molecular mechanisms of epithelial-mesenchymal transitionNature Reviews Molecular Cell Biology20144.7K
Myeloid-derived suppressor cells as regulators of the immune systemNature Reviews Immunology20094.6K
Alternative activation of macrophagesNature Reviews Immunology20034.6K
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responsesAnnual Review of Immunology19984.5K
Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alphaJournal of Experimental Medicine19944.3K
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaProceedings of the National Academy of Sciences of the United States of America20024K
The Fas death factorScience19953.7K
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesNature Immunology20053.6K
IL-17 and Th17 CellsAnnual Review of Immunology20093.6K
Astrocyte-endothelial interactions at the blood-brain barrierNature Reviews Neuroscience20063.6K
Why do cancers have high aerobic glycolysis?Nature Reviews Cancer20043.5K